Autologous stem-cell transplantation (also called autogenous, autogenic, or autogenic stem-cell transplantation and abbreviated auto-SCT) is the autologous transplantation of

stem cell In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell ...

s—that is, transplantation in which stem cells ( undifferentiated cells from which other cell types develop) are removed from a person, stored, and later given back to that same person. Although it is most frequently performed with

hematopoietic stem cell Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the ...

s (precursors of blood-forming cells) in

hematopoietic stem cell transplantation Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce ...

, cardiac cells have also been used successfully to repair damage caused by heart attacks. Autologous stem-cell transplantation is distinguished from allogenic stem cell transplantation where the donor and the recipient of the stem cells are different people. It can be also used as an

Assisted reproductive technology Assisted reproductive technology (ART) includes medical procedures used primarily to address infertility. This subject involves procedures such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation of ga ...

to improve the reproductive outcomes. In a first step the bone marrow derived stem cells are mobilized. After that they will be isolated from the peripheral blood by

apheresis Apheresis ( ἀφαίρεσις (''aphairesis'', "a taking away")) is a medical technology in which the blood of a person is passed through an apparatus that separates one particular constituent and returns the remainder to the circulation. ...

. The treated stem cells will then be infused into the

ovarian artery The ovarian artery is an artery that supplies oxygenated blood to the ovary in females. It arises from the abdominal aorta below the renal artery. It can be found within the suspensory ligament of the ovary, anterior to the ovarian vein and urete ...

through catheterism.

References

9. Herraiz et al., (2018). Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders. ''Fertil Steril, 110(3)'', 496-505. *

External links

Autologous stem-cell transplantation
entry in the public domain NCI Dictionary of Cancer Terms

University of Louisville. "Two years out, patients receiving stem cell therapy show sustained heart function improvement, study suggests." ScienceDaily, 6 Nov. 2012. Web. 6 Nov. 2012. Transplantation medicine Stem cells {{treatment-stub

See also

References

External links