In
urologic
Urology (from Ancient Greek, Greek wikt:οὖρον, οὖρον ''ouron'' "urine" and ''wiktionary:-logia, -logia'' "study of"), also known as genitourinary surgery, is the branch of medicine that focuses on surgical and medical diseases of t ...
pathology
Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...
, atypical small
acinar
An acinus (; plural, acini; adjective, acinar or acinous) refers to any cluster of cells that resembles a many-lobed "berry," such as a raspberry (''acinus'' is Latin for "berry"). The berry-shaped termination of an exocrine gland, where the ...
proliferation, is a collection of small prostatic
gland
In animals, a gland is a group of cells in an animal's body that synthesizes substances (such as hormones) for release into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland).
Structure
De ...
s, on
prostate biopsy
A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist. The process involves extraction of sample cells or tissues for examination to determine the presence or extent of a diseas ...
, whose significance is uncertain and cannot be determined to be
benign or
malignant.
ASAP, generally, is ''not'' considered a pre-malignancy, or a
carcinoma in situ; it is an expression of diagnostic
uncertainty
Uncertainty refers to epistemic situations involving imperfect or unknown information. It applies to predictions of future events, to physical measurements that are already made, or to the unknown. Uncertainty arises in partially observable or ...
, and
analogous to the diagnosis of
ASCUS
An ascus (; ) is the sexual spore-bearing cell produced in ascomycete fungi. Each ascus usually contains eight ascospores (or octad), produced by meiosis followed, in most species, by a mitotic cell division. However, asci in some genera or s ...
(atypical squamous cells of undetermined significance) on the
Pap test.
Association with adenocarcinoma
On a subsequent
biopsy
A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist. The process involves extraction of sample cells or tissues for examination to determine the presence or extent of a diseas ...
, given the diagnosis of ASAP, the chance of finding prostate
adenocarcinoma
Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ) (AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ...
is approximately 40%; this is higher than if there is
high-grade prostatic intraepithelial neoplasia
High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer).
It may be referred to simply as prostatic in ...
(HGPIN).
Management
ASAP is considered an
indication
Indication may refer to:
* A synonym for sign
* Human interface, highlighting the single object pointed to as a cursor is moved, without any other user action such as clicking, is indication
* Indication (medicine). A valid reason to use a certain ...
for re-biopsy; in one survey of
urologist
Urology (from Greek οὖρον ''ouron'' "urine" and ''-logia'' "study of"), also known as genitourinary surgery, is the branch of medicine that focuses on surgical and medical diseases of the urinary-tract system and the reproductive organ ...
s
98% of respondents considered it a sufficient reason to re-biopsy.
See also
*
Sensitivity
References
External links
{{DEFAULTSORT:Atypical Small Acinar Proliferation
Pathology
Male genital disorders