Arthur S. Tischler (born 1946) is an

American American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, p ...

surgical pathologist Surgical pathology is the most significant and time-consuming area of practice for most anatomical pathology, anatomical pathologists. Surgical pathology involves gross and microscopic examination of surgery, surgical specimens, as well as biop ...

and

professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin ...

pathology Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

Tufts University Tufts University is a private research university in Medford and Somerville, Massachusetts, United States, with additional facilities in Boston and Grafton, as well as Talloires, France. Tufts also has several Doctor of Physical Therapy p ...

School of Medicine A medical school is a tertiary educational institution, professional school, or forms a part of such an institution, that teaches medicine, and awards a professional degree for physicians. Such medical degrees include the Bachelor of Medicine, ...

. He is best known for his research on

catecholamine A catecholamine (; abbreviated CA), most typically a 3,4-dihydroxyphenethylamine, is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine. Cate ...

-producing

neuroendocrine tumors Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lu ...

, particularly

pheochromocytoma Pheochromocytoma is a rare tumor of the adrenal medulla composed of chromaffin cells and is part of the paraganglioma (PGL) family of tumors, being defined as an intra-adrenal PGL. These neuroendocrine tumors can be sympathetic, where they relea ...

and

paraganglioma A paraganglioma is a rare neuroendocrine tumour, neuroendocrine neoplasm that may develop at various body sites (including the head, neck, thorax and abdomen). When the same type of tumor is found in the adrenal gland, they are referred to as a p ...

Career

Tischler completed his

medical training Medical education is education related to the practice of being a medical practitioner, including the initial training to become a physician (i.e., medical school and internship) and additional training thereafter (e.g., residency, fellowship, ...

and

residency Residency may refer to: * Artist-in-residence, a program to sponsor the residence and work of visual artists, writers, musicians, etc. * Concert residency, a series of concerts performed at one venue * Domicile (law), the act of establishing or m ...

at Beth Israel Deaconness Medical Center and

Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...

Boston Boston is the capital and most populous city in the Commonwealth (U.S. state), Commonwealth of Massachusetts in the United States. The city serves as the cultural and Financial centre, financial center of New England, a region of the Northeas ...

(1971–1976), serving as Chief Resident in 1976. He then worked as a pathologist at

Walter Reed Army Medical Center The Walter Reed Army Medical Center (WRAMC), officially known as Walter Reed General Hospital (WRGH) until 1951, was the United States Army, U.S. Army's flagship medical center from 1909 to 2011. Located on in Washington, D.C., it served more ...

(1976–1978), before joining Tufts Medical Center. At

Tufts Tufts University is a private research university in Medford and Somerville, Massachusetts, United States, with additional facilities in Boston and Grafton, as well as Talloires, France. Tufts also has several Doctor of Physical Therapy progr ...

, he became a senior

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

and professor of

and

laboratory A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which scientific or technological research, experiments, and measurement may be performed. Laboratories are found in a variety of settings such as schools ...

medicine.

Research

Tischler's early research helped establish that

cells could undergo neuron-like differentiation in response to

nerve growth factor Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was ...

(NGF). In 1976, he and Lloyd Greene co-developed the widely used PC12

cell line An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells ...

. He later co-developed MPC

cell lines An immortalised cell line is a population of cells from a multicellular organism that would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells ...

from genetically modified mice to study

. In 2020, he co-developed RS0, the first

SDHB Succinate dehydrogenase biquinoneiron-sulfur subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the ''SDHB'' gene. The succinate dehydrogenase (also called SDH or Compl ...

-mutant, SDH-deficient

model.

Leadership and editorial roles

Tischler served as President of the Endocrine Pathology Society (2001–2002) and was Editor-in-Chief of ''Endocrine Pathology'' (2002–2008). He is also a founding member of the

Pheochromocytoma Pheochromocytoma is a rare tumor of the adrenal medulla composed of chromaffin cells and is part of the paraganglioma (PGL) family of tumors, being defined as an intra-adrenal PGL. These neuroendocrine tumors can be sympathetic, where they relea ...

Research Support Organization (PRESSOR), where he co-chaired the tumor models working group.

International classification work

Tischler has contributed to the

World Health Organization The World Health Organization (WHO) is a list of specialized agencies of the United Nations, specialized agency of the United Nations which coordinates responses to international public health issues and emergencies. It is headquartered in Gen ...

(WHO) classification of endocrine tumors, authoring chapters in the 2004, 2017, and 2024 editions. He also leads the expert panel on

pheochromocytomas Pheochromocytoma is a rare tumor of the adrenal medulla composed of chromaffin cells and is part of the paraganglioma (PGL) family of tumors, being defined as an intra-adrenal PGL. These neuroendocrine tumors can be sympathetic, where they relea ...

and paragangliomas for the International Collaboration on

Cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...

Reporting (ICCR).

Recognition

* 2000 – Founding member of PRESSOR * 2011 – Science Honoree, PheoPara Alliance * 2025 – Lifetime Achievement Award, Endocrine Pathology Society

Research collaborations

Tischler contributed to the Cancer Genome Atlas (TCGA) pheochromocytoma/ paraganglioma study, and is a collaborator in the Australian-Asian-American Adrenal Alliance (A5).

Selected publications

* Tischler AS, Greene LA. "Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells." ''Nature''. 1975. * Greene LA, Tischler AS. "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells..." ''PNAS''. 1976. * Powers JF, et al. "A xenograft and cell line model of SDH-deficient pheochromocytoma..." ''Endocrine-Related Cancer''. 2020.

References

External links

Official website
{{DEFAULTSORT:Tischler, Arthur S. American pathologists Tufts University faculty 1946 births Living people