Arterolane, also known as OZ277 or RBx 11160, is an
antimalarial
Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young ...
compound marketed by
Ranbaxy Laboratories.
It was discovered by US and European scientists coordinated by the
Medicines for Malaria Venture (MMV). Its molecular structure is uncommon for pharmacological compounds in that it has both an
ozonide
Ozonide is the polyatomic anion . Cyclic organic compounds formed by the addition of ozone () to an alkene are also called ozonides.
Ionic ozonides
Inorganic ozonides are dark red salts. The anion has the bent shape of the ozone molecule.
In ...
(trioxolane) group and an
adamantane
Adamantane is an organic compound with formula C10H16 or, more descriptively, (CH)4(CH2)6. Adamantane molecules can be described as the fusion of three cyclohexane rings. The molecule is both rigid and virtually stress-free. Adamantane is the mo ...
substituent.
Initial results were disappointing, and in 2007 MMV withdrew support, after having invested $20M in the research;
[ Ranbaxy said at the time that it intended to continue developing arterolane in combination with another drug.][ In 2009, Ranbaxy started a Phase II clinical trial of arterolane in combination with piperaquine, and it was published in 2015.]combination drug
A combination drug is a combination of two or more pharmaceutical drugs as active ingredients combined into a single dosage form, typically as a ''fixed-dose combination'', with each constituent standardized to specifications of a fixed dose. Fix ...
in India, under the brand name Synriam.
References
Antimalarial agents
Adamantanes
Organic peroxides
Spiro compounds
Carboxamides
Amines
Cyclohexanes
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