An antiseptic ( and ) is an
antimicrobial substance or compound that is applied to living
tissue to reduce the possibility of
sepsis
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.
This initial stage of sepsis is followed by suppression of the immune system. Common signs and s ...
,
infection
An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...
, or
putrefaction
Putrefaction is the fifth stage of death, following pallor mortis, livor mortis, algor mortis, and rigor mortis. This process references the breaking down of a body of an animal Post-mortem interval, post-mortem. In broad terms, it can be view ...
. Antiseptics are generally distinguished from ''
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...
s'' by the latter's ability to safely destroy bacteria within the body, and from ''
disinfectant
A disinfectant is a chemical substance or compound used to inactivate or destroy microorganisms on inert surfaces. Disinfection does not necessarily kill all microorganisms, especially resistant bacterial spores; it is less effective than ...
s'', which destroy microorganisms found on non-living objects.
Antibacterials include antiseptics that have the proven ability to act against bacteria.
Microbicides which destroy virus particles are called
viricides or
antivirals
Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Antiviral drugs are a class of antimicrobials ...
.
Antifungals, also known as
antimycotics, are pharmaceutical
fungicide
Fungicides are pesticides used to kill parasitic fungi or their spores. Fungi can cause serious damage in agriculture, resulting in losses of yield and quality. Fungicides are used both in agriculture and to fight fungal infections in animals, ...
s used to treat and prevent
mycosis
Fungal infection, also known as mycosis, is a disease caused by fungi. Different types are traditionally divided according to the part of the body affected: superficial, subcutaneous, and systemic. Superficial fungal infections include common ...
(fungal infection).
Surgery
Antiseptic practices evolved in the 19th century through multiple individuals.
Ignaz Semmelweis
Ignaz Philipp Semmelweis (; ; 1 July 1818 – 13 August 1865) was a Hungarian physician and scientist of German descent who was an early pioneer of antiseptic procedures and was described as the "saviour of mothers". Postpartum infections, ...
showed already in 1847-1848 that
hand washing
Hand washing (or handwashing), also known as hand hygiene, is the act of cleaning one's hands with soap, soap or handwash and water to remove viruses, bacteria, microorganisms, dirt, grease, and other harmful or unwanted substances stuck to th ...
prior to
delivery reduced
puerperal fever. Despite this, many hospitals continued to practice surgery in unsanitary conditions, with some surgeons taking pride in their bloodstained operating gowns.

Only a decade later the situation started to change, when some French surgeons started to adopt
carbolic acid as an antiseptic, reducing surgical infection rates, followed by their Italian colleagues in the 1860s. In 1867
Joseph Lister published seminal paper ''
Antiseptic Principle of the Practice of Surgery'', where he explained this reduction in terms of
Louis Pasteur
Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist, pharmacist, and microbiologist renowned for his discoveries of the principles of vaccination, Fermentation, microbial fermentation, and pasteurization, the la ...
's
germ theory. Thus he was able to popularize the antiseptic
surgical methods in the English-speaking world.
Some of this work was anticipated by:
*
Ancient Greek
Ancient Greek (, ; ) includes the forms of the Greek language used in ancient Greece and the classical antiquity, ancient world from around 1500 BC to 300 BC. It is often roughly divided into the following periods: Mycenaean Greek (), Greek ...
physicians
Galen
Aelius Galenus or Claudius Galenus (; September 129 – AD), often Anglicization, anglicized as Galen () or Galen of Pergamon, was a Ancient Rome, Roman and Greeks, Greek physician, surgeon, and Philosophy, philosopher. Considered to be one o ...
() and
Hippocrates
Hippocrates of Kos (; ; ), also known as Hippocrates II, was a Greek physician and philosopher of the Classical Greece, classical period who is considered one of the most outstanding figures in the history of medicine. He is traditionally referr ...
() as well as
Sumer
Sumer () is the earliest known civilization, located in the historical region of southern Mesopotamia (now south-central Iraq), emerging during the Chalcolithic and Early Bronze Age, early Bronze Ages between the sixth and fifth millennium BC. ...
ian clay tablets dating from 2150 BC that advocate the use of similar techniques.
*
Florence Nightingale
Florence Nightingale (; 12 May 1820 – 13 August 1910) was an English Reform movement, social reformer, statistician and the founder of modern nursing. Nightingale came to prominence while serving as a manager and trainer of nurses during th ...
, who contributed substantially to the report of the
Royal Commission on the Health of the Army (1856–1857), based on her earlier work
* Medieval surgeons
Hugh of Lucca, Theoderic of Servia, and his pupil
Henri de Mondeville were opponents of Galen's opinion that
pus was important to healing, which had led ancient and medieval surgeons to let pus remain in wounds. They advocated draining and cleaning the wound edges with wine, dressing the wound after suturing, if necessary and leaving the dressing on for ten days, soaking it in warm wine all the while, before changing it. Their theories were bitterly opposed by Galenist
Guy de Chauliac and others trained in the classical tradition.
*
Oliver Wendell Holmes Sr., who published ''The Contagiousness of Puerperal Fever'' in 1843
Some common antiseptics
Antiseptics can be subdivided into about eight classes of materials. These classes can be subdivided according to their mechanism of action: small molecules that indiscriminately react with organic compounds and kill microorganisms (peroxides, iodine, phenols) and more complex molecules that disrupt the cell walls of the bacteria.
*
Alcohol
Alcohol may refer to:
Common uses
* Alcohol (chemistry), a class of compounds
* Ethanol, one of several alcohols, commonly known as alcohol in everyday life
** Alcohol (drug), intoxicant found in alcoholic beverages
** Alcoholic beverage, an alco ...
s, including
ethanol
Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula . It is an Alcohol (chemistry), alcohol, with its formula also written as , or EtOH, where Et is the ps ...
and 2-propanol/
isopropanol
Isopropyl alcohol (IUPAC name propan-2-ol and also called isopropanol or 2-propanol) is a colorless, flammable, organic compound with a pungent alcoholic odor.
Isopropyl alcohol, an organic polar molecule, is miscible in water, ethanol, an ...
are sometimes referred to as ''
surgical spirit''. They are used to disinfect the skin before injections, among other uses.
*
Diguanides including
chlorhexidine gluconate, a bacteriocidal antiseptic which (with an alcoholic solvent) is considered a safe and effective antiseptic for reducing the risk of infection after clean surgery, including tourniquet-controlled upper limb surgery. It is also used in mouthwashes to treat inflammation of the gums (
gingivitis).
Polyhexanide (polyhexamethylene biguanide, PHMB) is an antimicrobial compound suitable for clinical use in critically colonized or infected acute and chronic wounds. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains.
*
Iodine, especially in the form of
povidone-iodine, is widely used because it is well tolerated; does not negatively affect wound healing; leaves a deposit of active iodine, thereby creating the so-called "remnant", or persistent effect; and has wide scope of antimicrobial activity. The traditional iodine antiseptic is an
alcohol
Alcohol may refer to:
Common uses
* Alcohol (chemistry), a class of compounds
* Ethanol, one of several alcohols, commonly known as alcohol in everyday life
** Alcohol (drug), intoxicant found in alcoholic beverages
** Alcoholic beverage, an alco ...
solution (called
tincture of iodine) or as
Lugol's iodine solution. Some studies
do not recommend disinfecting minor wounds with iodine because of concern that it may induce scar tissue formation and increase healing time. However, concentrations of 1% iodine or less have not been shown to increase healing time and are not otherwise distinguishable from treatment with saline.
Iodine will kill all principal pathogens and, given enough time, even
spores, which are considered to be the most difficult form of microorganisms to be inactivated by disinfectants and antiseptics.
*
Octenidine dihydrochloride, currently increasingly used in continental Europe, often as a chlorhexidine substitute.
*
Peroxide
In chemistry, peroxides are a group of Chemical compound, compounds with the structure , where the R's represent a radical (a portion of a complete molecule; not necessarily a free radical) and O's are single oxygen atoms. Oxygen atoms are joined ...
s, such as
hydrogen peroxide
Hydrogen peroxide is a chemical compound with the formula . In its pure form, it is a very pale blue liquid that is slightly more viscosity, viscous than Properties of water, water. It is used as an oxidizer, bleaching agent, and antiseptic, usua ...
and
benzoyl peroxide
Benzoyl peroxide is a chemical compound (specifically, an organic peroxide) with structural formula , often abbreviated as (BzO)2. In terms of its structure, the molecule can be described as two benzoyl (, Bz) groups connected by a peroxide ...
. Commonly, 3% solutions of hydrogen peroxide have been used in household first aid for scrapes, etc. However, the strong oxidization causes scar formation and increases healing time during fetal development.
*
Phenols
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (− O H) bonded directly to an aromatic hydrocarbon group. The simplest is phenol, . Phenolic compounds ar ...
such as phenol itself (as introduced by Lister) and
triclosan
Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of act ...
,
hexachlorophene,
chlorocresol, and
chloroxylenol. The fact that the more substituted and more
lipophylic phenols are less toxic, less irritant and more powerful was gradually discovered in late 19th century.
Nowadays comparatively more water-soluble phenols such as chlorocresol are commonly used as preservatives in personal care products while less soluble such as chloroxylenol – as topical antiseptics. Both can be encountered in household disinfectants.
*
Quat salts such as
benzalkonium chloride/lidocaine (trade name Bactine among others),
cetylpyridinium chloride
Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound used in some types of mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. It is an antiseptic that kills bacteria and other microor ...
, or
cetrimide. These surfactants disrupt cell walls.
*
Quinoline
Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. It is a colorless hygroscopic liquid with a strong odor. Aged samples, especially if exposed to light, become yellow and later brown. Quinoline is only sl ...
s such as hydroxyquinolone, dequalium chloride, or
chlorquinaldol.
*
4-Hexylresorcinol, or S.T.37
See also
*
Actinonin
*
Henry Jacques Garrigues, introduced antiseptic obstetrics to North America
References
External links
*
*
{{Authority control
Bactericides