Anhalonidine, also known as ''N''-desmethylpellotine, a naturally occurring

tetrahydroisoquinoline Tetrahydroisoquinoline (TIQ or THIQ), also known as AMPH-CR, is an organic compound with the chemical formula C9H11N. Classified as a secondary amine, it is derived from isoquinoline by hydrogenation. It is a colorless viscous liquid that is mis ...

alkaloid Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids. Alkaloids are produced by a large varie ...

which can be isolated from certain members of the

cactus A cactus (: cacti, cactuses, or less commonly, cactus) is a member of the plant family Cactaceae (), a family of the order Caryophyllales comprising about 127 genera with some 1,750 known species. The word ''cactus'' derives, through Latin, ...

family, such as ''

Lophophora ''Lophophora'' () is a genus of spineless, button-like cacti. Its native range covers Texas through Mexico to southwestern Mexico. The species are extremely slow growing, sometimes taking up to thirty years to reach flowering age (at the size o ...

''. It is structurally related to

mescaline Mescaline, also known as mescalin or mezcalin, and in chemical terms 3,4,5-trimethoxyphenethylamine, is a natural product, naturally occurring psychedelic drug, psychedelic alkaloid, protoalkaloid of the substituted phenethylamine class, found ...

. Anhalonidine produced no

hallucinogen Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mo ...

ic effects in humans at doses of up to 250mg. However, it has been reported to have a calming or

sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its decelera ...

effect instead, with about one-fourth the

potency Potency may refer to: * Potency (pharmacology), a measure of the activity of a drug in a biological system * Virility * Cell potency, a measure of the differentiation potential of stem cells * In homeopathic dilutions, potency is a measure of ho ...

pellotine Pellotine, also known as peyotline or ''N''-methylanhalonidine, is a tetrahydroisoquinoline alkaloid found in '' Lophophora'' species, in particular ''L. diffusa''. It is the second most common alkaloid found in ''Lophophora williamsii'' (peyo ...

and with marked

sedation Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, ...

occurring at doses of 100 to 250mg. Anhalonidine has been found to act as a potent

inverse agonist In pharmacology, an inverse agonist is a drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist. A neutral antagonist has no activity in the absence of an agonist or inverse agon ...

of the

serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...

5-HT₇ receptor.

References

External links

Anhalonidine - Isomer Design
5-HT7 antagonists Hypnotics Lophophora Norsalsolinol ethers Sedatives Tetrahydroisoquinoline alkaloids {{Alkaloid-stub

See also

References

External links