Angiotensin (1-7) on:
[Wikipedia]
[Google]
[Amazon]
Angiotensin (1-7) (; Molecular weight = 899.02 g/mol; H-
Asp
Asp may refer to:
Places
* Asp, part of Densbüren, Aargau, Switzerland
* Aspe (''Asp'' in Valencian), Alicante, Spain
* Asp Lake, a lake in Minnesota
Animals
* Asp (fish)
* Asp (snake), in antiquity, one of several venomous snakes
** ''Cera ...
- Arg-Val
Val may refer to: Val-a
Film
* ''Val'' (film), an American documentary about Val Kilmer, directed by Leo Scott and Ting Poo
Military equipment
* Aichi D3A, a Japanese World War II dive bomber codenamed "Val" by the Allies
* AS Val, a Sov ...
- Tyr-Ile
Ile may refer to:
* iLe, a Puerto Rican singer
* Ile District (disambiguation), multiple places
* Ilé-Ifẹ̀, an ancient Yoruba city in south-western Nigeria
* Interlingue (ISO 639:ile), a planned language
* Isoleucine, an amino acid
* Another ...
- His- Pro-OH) is an active heptapeptide of the renin–angiotensin system (RAS).
In 1988, Santos ''et al'' demonstrated that angiotensin (1-7) was a main product of the incubation of angiotensin I with brain micropunches and Schiavone ''et al'' reported the first biological effect of this heptapeptide.
Angiotensin (1-7) is a vasodilator agent affecting cardiovascular organs, such as heart, blood vessels and kidneys, with functions frequently opposed to those attributed to the major effector component of the RAS, angiotensin II (Ang II).
Synthesis
The polypeptide Ang I can be converted into Ang (1-7) by the actions of neprilysin (NEP) and thimet oligopeptidase (TOP) enzymes. Also, Ang II can behydrolyzed
Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile.
Biological hydrolysis ...
into Ang (1-7) through the actions of angiotensin-converting enzyme 2 (ACE2). Ang (1-7) binds and activates the G-protein coupled receptor Mas receptor leading to opposite effects of those of Ang II.
Possible pathways
* Action of neprilysin on angiotensin I or angiotensin II. * Action of prolyl endopeptidase on angiotensin I. * Action of ACE on angiotensin 1-9. * Action of neprilysin on angiotensin 1-9. * Action of ACE2 on angiotensin II.Effects
Ang (1-7) has been shown to have anti-oxidant and anti-inflammatory effects. It helps protect cardiomyocytes of spontaneously hypertensive rats by increasing the expression of endothelial and neuronal nitric oxide synthase enzymes, augmenting production of nitric oxide.Pharmacological interactions
Ang (1-7) contributes to the beneficial effects of ACE inhibitors and angiotensin II receptor type 1 antagonists.References
{{Reflist Peptides Angiology Endocrinology Hypertension