Angiolathyrism is a form of

lathyrism Lathyrism is a condition caused by eating certain legumes of the genus ''Lathyrus''. There are three types of lathyrism: ''neurolathyrism'', ''osteolathyrism'', and ''angiolathyrism'', all of which are incurable, differing in their symptoms and ...

disease. It is mainly caused the consumption of ''

Lathyrus sativus ''Lathyrus sativus'', also known as grass pea, cicerchia, blue sweet pea, chickling pea, chickling vetch, Indian pea, white pea and white vetch, is a legume (family Fabaceae) commonly grown for human consumption and livestock feed in Asia and Eas ...

'' (also known as ''grass pea'') and to a lesser degree by ''

Lathyrus cicera ''Lathyrus cicera'' is a species of wild pea known by the common names red pea, red vetchling and flatpod peavine. It is native to Europe, North Africa, and the Middle East, and it is known from other places as an introduced species. This is a h ...

'', '' Lathyrus ochrus'' and ''

Lathyrus clymenum ''Lathyrus clymenum'', also called Spanish vetchling, is a flowering plant in the family Fabaceae, native to the Mediterranean. The seeds are used to prepare a Greek dish called fava santorinis. The plant is cultivated on the island of Santorin ...

''"Medical problems caused by plants: Lathyrism"
at ''Prince Leopold Institute of Tropical Medicine'' online database containing the

toxin A toxin is a naturally occurring poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919), derived ...

ODAP Oxalyldiaminopropionic acid (ODAP) is a structural analogue of the neurotransmitter glutamate found in the grass pea ''Lathyrus sativus''. It is the neurotoxin responsible for the motor neuron degeneration syndrome lathyrism. Sources ODAP is foun ...

. The main chemical responsible is β-

Aminopropionitrile Aminopropionitrile, also known as β-aminopropionitrile (BAPN), is an organic compound with both amine and nitrile functional groups. It is a colourless liquid. The compound occurs naturally and is of interest in the biomedical community. Biochemi ...

, which prevents collagen cross-linking, thus making the blood vessel, especially the

tunica media The tunica media (Neo-Latin "middle coat"), or media for short, is the middle tunica (layer) of an artery or vein. It lies between the internal elastic lamina of the tunica intima on the inside and the tunica externa on the outside. Artery The ...

, weak. This can result in Cystic medial necrosis or a picture similar to

Marfan syndrome Marfan syndrome (MFS) is a multi-systemic genetic disorder that affects the connective tissue. Those with the condition tend to be tall and thin, with dolichostenomelia, long arms, legs, Arachnodactyly, fingers, and toes. They also typically ha ...

. The damaged vessels are at an increased risk of

dissection Dissection (from Latin ' "to cut to pieces"; also called anatomization) is the dismembering of the body of a deceased animal or plant to study its anatomical structure. Autopsy is used in pathology and forensic medicine to determine the cause of ...

. Unlike osteolathyrism, the blood vessels are affected instead of bone. However it is caused by similar action and is typically associated with the other forms of lathyrism.

References

Toxic effect of noxious substances eaten as food Neurological disorders {{Nervoussystem-disease-stub}