Amflora
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Amflora (also known as EH92-527-1) is a genetically modified potato
cultivar A cultivar is a kind of Horticulture, cultivated plant that people have selected for desired phenotypic trait, traits and which retains those traits when Plant propagation, propagated. Methods used to propagate cultivars include division, root a ...
developed by BASF Plant Science. "Amflora"
potato The potato () is a starchy tuberous vegetable native to the Americas that is consumed as a staple food in many parts of the world. Potatoes are underground stem tubers of the plant ''Solanum tuberosum'', a perennial in the nightshade famil ...
plants produce pure
amylopectin Amylopectin is a water-insoluble polysaccharide and highly branched polymer of α-glucose units found in plants. It is one of the two components of starch, the other being amylose. Plants store starch within specialized organelles called amyloplas ...
starch that is processed to
waxy potato starch Waxy potato starch is a variety of commercially available starch composed almost entirely of amylopectin molecules, extracted from new potato varieties. Standard starch extracted from traditional potato varieties contains both amylose and amylopect ...
. It was approved for industrial applications in the
European Union The European Union (EU) is a supranational union, supranational political union, political and economic union of Member state of the European Union, member states that are Geography of the European Union, located primarily in Europe. The u ...
on 2 March 2010 by the
European Commission The European Commission (EC) is the primary Executive (government), executive arm of the European Union (EU). It operates as a cabinet government, with a number of European Commissioner, members of the Commission (directorial system, informall ...
. In January 2012, the potato was withdrawn from the market in the EU.


History

Originally registered on 5 August 1996, Amflora was developed by
geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic process ...
Lennart Erjefält and
agronomist An agriculturist, agriculturalist, agrologist, or agronomist (abbreviated as agr.) is a professional in the science, practice, and management of agriculture and agribusiness. It is a regulated profession in Canada, India, the Philippines, the Uni ...
Jüri Känno of Svalöf Weibull AB. After the European Commission's approval of the potato, BASF announced it was going to produce Amflora seed starting in April 2010 in Germany's
Western Pomerania Historical Western Pomerania, also called Cispomerania, Fore Pomerania, Front Pomerania or Hither Pomerania (; ), is the western extremity of the historic region of Pomerania, located mostly in north-eastern Germany, with a small portion in no ...
(20 ha) and
Sweden Sweden, formally the Kingdom of Sweden, is a Nordic countries, Nordic country located on the Scandinavian Peninsula in Northern Europe. It borders Norway to the west and north, and Finland to the east. At , Sweden is the largest Nordic count ...
(80 ha). It also announced it was planting 150 ha in the
Czech Republic The Czech Republic, also known as Czechia, and historically known as Bohemia, is a landlocked country in Central Europe. The country is bordered by Austria to the south, Germany to the west, Poland to the northeast, and Slovakia to the south ...
"for commercial aims with an unnamed partner." Due to lack of acceptance of GM crops in Europe, BASF Plant Science decided in January 2012 to stop its commercialization activities in Europe and would no longer sell Amflora there, but it would continue seeking regulatory approval for its products in the Americas and Asia.James Kanter for ''The New York Times''. January 16, 2012
BASF to Stop Selling Genetically Modified Products in Europe
/ref> In 2013, an EU court annulled the approval of BASF's Amflora, saying that the EU Commission broke rules when it approved the potato in 2010.


Biology

Waxy potato varieties produce two main kinds of potato starch,
amylose Amylose is a polysaccharide made of α-D-glucose units, bonded to each other through α(1→4) glycosidic bonds. It is one of the two components of starch, making up approximately 20–25% of it. Because of its tightly packed Helix, helical struct ...
and
amylopectin Amylopectin is a water-insoluble polysaccharide and highly branched polymer of α-glucose units found in plants. It is one of the two components of starch, the other being amylose. Plants store starch within specialized organelles called amyloplas ...
, the latter of which is most industrially useful. The Amflora potato has been modified to contain
antisense In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, ...
RNA Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...
against the enzyme that drives synthesis of amylose, namely granule bound starch synthase. This resulting potato almost exclusively produces
amylopectin Amylopectin is a water-insoluble polysaccharide and highly branched polymer of α-glucose units found in plants. It is one of the two components of starch, the other being amylose. Plants store starch within specialized organelles called amyloplas ...
, and thus is more useful for the starch industry.


Industrial applications

Regular potato starch contains two constituent types of molecules: amylopectin (80 percent), which is more useful as a
polymer A polymer () is a chemical substance, substance or material that consists of very large molecules, or macromolecules, that are constituted by many repeat unit, repeating subunits derived from one or more species of monomers. Due to their br ...
for industry, and
amylose Amylose is a polysaccharide made of α-D-glucose units, bonded to each other through α(1→4) glycosidic bonds. It is one of the two components of starch, making up approximately 20–25% of it. Because of its tightly packed Helix, helical struct ...
(20 percent) which often creates problems as starch retrogradation, so must be modified with chemical reactions which can be costly.http://www.basf.com/group/corporate/en/function/conversions:/publish/content/products-and-industries/biotechnology/plant-biotechnology/images/BASF_Plant_Science_Amflora.pdf After two decades of research efforts, BASF's biotechnologists using
genetic engineering Genetic engineering, also called genetic modification or genetic manipulation, is the modification and manipulation of an organism's genes using technology. It is a set of Genetic engineering techniques, technologies used to change the genet ...
succeeded in creating a potato, named "Amflora", where the gene responsible for the synthesis of amylose had been turned off, thus the potato is unable to synthesize the less desirable amylose. Amflora potatoes would be processed and sold as
starch Starch or amylum is a polymeric carbohydrate consisting of numerous glucose units joined by glycosidic bonds. This polysaccharide is produced by most green plants for energy storage. Worldwide, it is the most common carbohydrate in human diet ...
to industries that prefer waxy potato starch with only amylopectin. Amflora is intended only for industrial applications such as
papermaking Papermaking is the manufacture of paper and cardboard, which are used widely for printing, writing, and packaging, among many other purposes. Today almost all paper is Pulp and paper industry, made using industrial machinery, while handmade pape ...
and other technical applications. Europe produces more than two million metric tons of natural potato starch a year, and BASF with its Amflora product hoped to enter into this large market.


Other possible uses

According to ''
The New York Times ''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
'', BASF has a second application pending for use of Amflora's potato pulp as
animal feed Animal feed is food given to domestic animals, especially livestock, in the course of animal husbandry. There are two basic types: fodder and forage. Used alone, the word ''feed'' more often refers to fodder. Animal feed is an important input ...
.


Political disagreements

Various environmental organizations, such as
Greenpeace Greenpeace is an independent global campaigning network, founded in Canada in 1971 by a group of Environmental movement, environmental activists. Greenpeace states its goal is to "ensure the ability of the Earth to nurture life in all its biod ...
, disagreed with the introduction of the Amflora genetically modified potato into the market. The lengthy approval process frustrated some supporters of the potato. A BASF scientist said to ''The New York Times'', "it's hard when you see an innovative product go through the loops again and again. These decisions are not about science but about politics". After the potato was approved, the European Greens political party and the then Italian agricultural minister
Luca Zaia Luca Zaia (born 27 March 1968) is an Italian politician, who has been President of Veneto since 2010, and a historical member of Lega Nord, other than being the most Progressivism in the United States, progressive member of his own party. Suppor ...
criticized the approval. The International Peasant Movement La Via Campesina issued a press release on 8 March 2010 also criticizing the decision.


Reactions by Greek politicians

After Amflora's licensing by the European Commission on 2 March 2010, the Coalition of the Radical Left's Member of Parliament for the A Thessalonikis prefecture, Tasos Kouvelis, asked the Greek Minister of Agriculture on 3 March 2010 to declare the production of the potato illegal in
Greece Greece, officially the Hellenic Republic, is a country in Southeast Europe. Located on the southern tip of the Balkan peninsula, it shares land borders with Albania to the northwest, North Macedonia and Bulgaria to the north, and Turkey to th ...
. On 4 March 2010
Panhellenic Socialist Movement The Panhellenic Socialist Movement (, ), known mostly by its acronym PASOK (; , ), is a social-democratic political party in Greece. Until 2012 it was one of the two major parties in the country, along with New Democracy, its main political r ...
's European Member of Parliament Kriton Arsenis submitted a question at
Europarl The European Parliament (EP) is one of the two Legislature, legislative bodies of the European Union and one of its Institutions of the European Union, seven institutions. Together with the Council of the European Union (known as the Council an ...
asking about the consequences of Amflora. PASOK's MP Maria Damanaki accepted the decision of the European Commission, while Greek Agriculture Minister Katerina Batzeli said the production of Amflora will not be allowed in Greece.


Licensing procedure

Amflora could not be sold within the European Union without approval, and its licence could only be issued after voting at the Council of Ministers of the European Union with a 74 percent threshold of support. Two rounds of voting were held, first by experts in December 2006 and then by the agricultural ministers in July 2007, but both failed to reach the 74 percent threshold. Although the voting was by
secret ballot The secret ballot, also known as the Australian ballot, is a voting method in which a voter's identity in an election or a referendum is anonymous. This forestalls attempts to influence the voter by intimidation, blackmailing, and potential vote ...
, ''The New York Times'' reported that Amflora was supported by the agricultural ministers of
Germany Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total popu ...
and
Belgium Belgium, officially the Kingdom of Belgium, is a country in Northwestern Europe. Situated in a coastal lowland region known as the Low Countries, it is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeas ...
, and was opposed by the agricultural ministers of
Italy Italy, officially the Italian Republic, is a country in Southern Europe, Southern and Western Europe, Western Europe. It consists of Italian Peninsula, a peninsula that extends into the Mediterranean Sea, with the Alps on its northern land b ...
,
Ireland Ireland (, ; ; Ulster Scots dialect, Ulster-Scots: ) is an island in the North Atlantic Ocean, in Northwestern Europe. Geopolitically, the island is divided between the Republic of Ireland (officially Names of the Irish state, named Irelan ...
, and
Austria Austria, formally the Republic of Austria, is a landlocked country in Central Europe, lying in the Eastern Alps. It is a federation of nine Federal states of Austria, states, of which the capital Vienna is the List of largest cities in Aust ...
, while the agricultural ministers of
France France, officially the French Republic, is a country located primarily in Western Europe. Overseas France, Its overseas regions and territories include French Guiana in South America, Saint Pierre and Miquelon in the Atlantic Ocean#North Atlan ...
and
Bulgaria Bulgaria, officially the Republic of Bulgaria, is a country in Southeast Europe. It is situated on the eastern portion of the Balkans directly south of the Danube river and west of the Black Sea. Bulgaria is bordered by Greece and Turkey t ...
abstained from voting. After a licence was issued on 2 March 2010, BASF announced its intention to ask for approval of more varieties of genetically modified potatoes, such as the "Fortuna" potato.


References


Further reading

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External links

{{Potato cultivars Genetically modified organisms in agriculture Potato cultivars BASF 1996 in biotechnology