Alexander Robertus Todd, Baron Todd (2 October 1907 – 10 January 1997) was a British
biochemist
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...
whose research on the structure and
synthesis
Synthesis or synthesize may refer to:
Science Chemistry and biochemistry
*Chemical synthesis, the execution of chemical reactions to form a more complex molecule from chemical precursors
**Organic synthesis, the chemical synthesis of organi ...
of
nucleotide
Nucleotides are Organic compound, organic molecules composed of a nitrogenous base, a pentose sugar and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both o ...
s,
nucleoside
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotid ...
s, and nucleotide
coenzyme
A cofactor is a non-protein chemical compound or Metal ions in aqueous solution, metallic ion that is required for an enzyme's role as a catalysis, catalyst (a catalyst is a substance that increases the rate of a chemical reaction). Cofactors can ...
s gained him the
Nobel Prize for Chemistry
The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outst ...
Glasgow
Glasgow is the Cities of Scotland, most populous city in Scotland, located on the banks of the River Clyde in Strathclyde, west central Scotland. It is the List of cities in the United Kingdom, third-most-populous city in the United Kingdom ...
, the elder son of Alexander Todd, JP, a clerk with the Glasgow Subway, and his wife, Jane Lowry.
He attended
Allan Glen's School
Allan Glen's School was, for most of its existence, a State school, local authority, selective Secondary education, secondary school for boys in Glasgow, Scotland, charging nominal fees for tuition.
It was founded by the Allan Glen's Endowment ...
and graduated from the
University of Glasgow
The University of Glasgow (abbreviated as ''Glas.'' in Post-nominal letters, post-nominals; ) is a Public university, public research university in Glasgow, Scotland. Founded by papal bull in , it is the List of oldest universities in continuous ...
with a bachelor's degree (BSc) in 1928. He received a doctorate (Dr Phil.nat.) from
Goethe University Frankfurt
Goethe University Frankfurt () is a public research university located in Frankfurt am Main, Germany. It was founded in 1914 as a citizens' university, which means it was founded and funded by the wealthy and active liberal citizenry of Frankfurt ...
in 1931 for his thesis on the chemistry of the
bile acid
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver in peroxisomes. Bile acids are conjugated with taurine or glycine residues to give anions called bile ...
Royal Commission for the Exhibition of 1851
The Royal Commission for the Exhibition of 1851 is an institution founded in 1850 to administer the Great Exhibition, Great Exhibition of the Works of Industry of all Nations, which was held in The Crystal Palace, London.
The founding Presid ...
, and, after studying at
Oriel College, Oxford
Oriel College () is Colleges of the University of Oxford, a constituent college of the University of Oxford in Oxford, England. Located in Oriel Square, the college has the distinction of being the oldest royal foundation in Oxford (a title for ...
, he received another doctorate (DPhil) in 1933.
Career
Todd held posts with the
Lister Institute
The Lister Institute of Preventive Medicine, informally known as the Lister Institute, was established as a research institute (the British Institute of Preventive Medicine) in 1891, with bacteriologist Marc Armand Ruffer as its first director, ...
, the
University of Edinburgh
The University of Edinburgh (, ; abbreviated as ''Edin.'' in Post-nominal letters, post-nominals) is a Public university, public research university based in Edinburgh, Scotland. Founded by the City of Edinburgh Council, town council under th ...
(staff, 1934–1936) and the
University of London
The University of London (UoL; abbreviated as Lond or more rarely Londin in Post-nominal letters, post-nominals) is a collegiate university, federal Public university, public research university located in London, England, United Kingdom. The ...
, where he was appointed Reader in biochemistry.
In 1938, Alexander Todd spent six months as a visiting professor at
California Institute of Technology
The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...
, eventually declining an offer of faculty position.
Todd became the Sir Samuel Hall Chair of Chemistry and director of the Chemical Laboratories of the
University of Manchester
The University of Manchester is a public university, public research university in Manchester, England. The main campus is south of Manchester city centre, Manchester City Centre on Wilmslow Road, Oxford Road. The University of Manchester is c ...
in 1938, where he began working on nucleosides, compounds that form the structural units of nucleic acids (
DNA
Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
and
RNA
Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...
University of Cambridge
The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...
, which he held until his retirement in 1971. In 1949, he synthesised
adenosine triphosphate
Adenosine triphosphate (ATP) is a nucleoside triphosphate that provides energy to drive and support many processes in living cell (biology), cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis. Found in all known ...
(ATP) and
flavin adenine dinucleotide
In biochemistry, flavin adenine dinucleotide (FAD) is a redox-active coenzyme associated with various proteins, which is involved with several enzymatic reactions in metabolism. A flavoprotein is a protein that contains a flavin group, which ma ...
(FAD). Todd served as a visiting professor at the
University of Chicago
The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...
in Autumn 1948 and
University of Sydney
The University of Sydney (USYD) is a public university, public research university in Sydney, Australia. Founded in 1850, it is the oldest university in both Australia and Oceania. One of Australia's six sandstone universities, it was one of the ...
in 1950.
By 1951 Todd an collaborators had determined by biochemical methods how the backbone of DNA is structured via the successive linking of carbon atoms 3 and 5 of the sugar to phosphates. This helped corroborate Watson and Crick's X-ray structural work published in 1953.
In 1955, he helped elucidate the structure of vitamin B12, although the final formula and definite structure was determined by
Dorothy Hodgkin
Dorothy Mary Crowfoot Hodgkin (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning English chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential for ...
and her team, and later worked on the structure and synthesis of vitamin B1 and
vitamin E
Vitamin E is a group of eight compounds related in molecular structure that includes four tocopherols and four tocotrienols. The tocopherols function as fat-soluble antioxidants which may help protect cell membranes from reactive oxygen speci ...
, the
anthocyanins
Anthocyanins (), also called anthocyans, are water-soluble vacuolar pigments that, depending on their pH, may appear red, purple, blue, or black. In 1835, the German pharmacist Ludwig Clamor Marquart named a chemical compound that gives flow ...
(the pigments of flowers and fruits) from insects (aphids, beetles) and studied
alkaloids
Alkaloids are a broad class of naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids.
Alkaloids are produced by a large variety of organisms i ...
found in
cannabis
''Cannabis'' () is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species be ...
. He served as chairman of the
Government of the United Kingdom
His Majesty's Government, abbreviated to HM Government or otherwise UK Government, is the central government, central executive authority of the United Kingdom of Great Britain and Northern Ireland.
's advisory committee on scientific policy from 1952 to 1964.
He is credited as the first person to synthesize H4-CBD and H2-CBD from
Cannabidiol
Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in ''Cannabis'', along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. Medically, it is an anticonvulsant used to treat multiple f ...
by
hydrogenation
Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to redox, reduce or Saturated ...
as early as 1940.
He received the 1957 Nobel Prize in Chemistry “for his work on nucleotides and nucleotide co-enzymes.”
Elected a
Fellow
A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...
of
Christ's College, Cambridge
Christ's College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge, England. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 250 graduate students. The c ...
in 1944, he served as
Master
Master, master's or masters may refer to:
Ranks or titles
In education:
*Master (college), head of a college
*Master's degree, a postgraduate or sometimes undergraduate degree in the specified discipline
*Schoolmaster or master, presiding office ...
from 1963 to 1978. Lord Todd became the first
Chancellor
Chancellor () is a title of various official positions in the governments of many countries. The original chancellors were the of Roman courts of justice—ushers, who sat at the (lattice work screens) of a basilica (court hall), which separa ...
of the new
University of Strathclyde
The University of Strathclyde () is a public research university located in Glasgow, Scotland. Founded in 1796 as the Andersonian Institute, it is Glasgow's second-oldest university, having received its royal charter in 1964 as the first techn ...
in 1965, and a visiting professor at Hatfield Polytechnic (1978–1986). Among his many honours, including over 40 honorary degrees, he was elected a
Fellow of the Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
in 1942, a member of the United States
National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...
in 1955, a member of the
American Academy of Arts and Sciences
The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...
in 1957, and the
American Philosophical Society
The American Philosophical Society (APS) is an American scholarly organization and learned society founded in 1743 in Philadelphia that promotes knowledge in the humanities and natural sciences through research, professional meetings, publicat ...
in 1965.
President of the Royal Society
The president of the Royal Society (PRS), also known as the Royal Society of London, is the elected Head of the Royal Society who presides over meetings of the society's council.
After an informal meeting (a lecture) by Christopher Wren at Gres ...
from 1975 to 1980, The Queen awarded him the Order of Merit in 1977.
In 1981, Todd became a founding member of the
World Cultural Council
The World Cultural Council is an international organization whose goals are to promote cultural values, goodwill and philanthropy among individuals. The organization founded in 1982 and based in Mexico, has held a yearly award ceremony since 198 ...
.
Personal life and death
In 1937, Todd married Alison Sarah Dale (d. 1987), daughter of Nobel Prize winner
Henry Hallett Dale
Sir Henry Hallett Dale (9 June 1875 – 23 July 1968) was an English pharmacologist and physiologist. For his study of acetylcholine as agent in the chemical transmission of nerve pulses (neurotransmission) he shared the 1936 Nobel Prize in Ph ...
, who like Todd, served as President of the
Royal Society of London
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, r ...
. They had a son and two daughters:
* Dr the Hon Alexander Henry Todd (b. 1939), educated at
Oriel College, Oxford
Oriel College () is Colleges of the University of Oxford, a constituent college of the University of Oxford in Oxford, England. Located in Oriel Square, the college has the distinction of being the oldest royal foundation in Oxford (a title for ...
, Master Salters' Company (1999/2000), m. 1stly 1967 (div 1981) Joan Margaret Koester, m. 2ndly Patricia Mary Harvey Jones, daughter of Brigadier Alan Harvey Jones , of Somerford Booths,
Cheshire
Cheshire ( ) is a Ceremonial counties of England, ceremonial county in North West England. It is bordered by Merseyside to the north-west, Greater Manchester to the north-east, Derbyshire to the east, Staffordshire to the south-east, and Shrop ...
;
* The Hon Helen Jean Todd (b. 1941), m. 1963 Philip Edgar Brown, and has two sons and a daughter;
* The Hon Hilary Alison Todd (b. 1946).
Todd died in Cambridge on 10 January 1997 at the age of 89 following a heart attack.
Honours
Todd was honoured as a Nieuwland Lecturer at the
University of Notre Dame
The University of Notre Dame du Lac (known simply as Notre Dame; ; ND) is a Private university, private Catholic research university in Notre Dame, Indiana, United States. Founded in 1842 by members of the Congregation of Holy Cross, a Cathol ...
in 1948, an Arthur D. Little Visiting Professor at
Massachusetts Institute of Technology
The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...
in 1954, and a Hitchcock Lecturer at
University of California, Berkeley
The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California), is a Public university, public Land-grant university, land-grant research university in Berkeley, California, United States. Founded in 1868 and named after t ...
, in 1957.
Knighted
A knight is a person granted an honorary title of a knighthood by a head of state (including the pope) or representative for service to the monarch, the church, or the country, especially in a military capacity.
The concept of a knighthood ...
as Sir Alexander Todd in 1954 he was elevated as a
Life Peer
In the United Kingdom, life peers are appointed members of the peerage whose titles cannot be inherited, in contrast to hereditary peers. Life peers are appointed by the monarch on the advice of the prime minister. With the exception of the D ...
on 16 April 1962, being created Baron Todd of
Trumpington
Trumpington is a village in Cambridgeshire, England, mostly located in Cambridge, with a small southern area of the village extending into the South Cambridgeshire district. As of the 2021 United Kingdom census, 2021 UK census, the village had ...
in the
County of Cambridge
Cambridgeshire (abbreviated Cambs.) is a ceremonial county in the East of England and East Anglia. It is bordered by Lincolnshire to the north, Norfolk to the north-east, Suffolk to the east, Essex and Hertfordshire to the south, Northampton ...
blue plaque
A blue plaque is a permanent sign installed in a public place in the United Kingdom, and certain other countries and territories, to commemorate a link between that location and a famous person, event, or former building on the site, serving a ...
erected by the
Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society and professional association in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the ...
Atherton–Todd reaction
The Atherton-Todd reaction is a name reaction in organic chemistry, which goes back to the British chemists F. R. Atherton, H. T. Openshaw and A. R. Todd. These described the reaction for the first time in 1945 as a method of converting Dialkyl ph ...
*
History of RNA biology
Numerous key discoveries in biology have emerged from studies of RNA (ribonucleic acid), including seminal work in the fields of biochemistry, genetics, microbiology, molecular biology, molecular evolution, and structural biology. As of 2010, 30 sc ...
*
List of RNA biologists
A list is a set of discrete items of information collected and set forth in some format for utility, entertainment, or other purposes. A list may be memorialized in any number of ways, including existing only in the mind of the list-maker, but ...
*
Presidents of the Royal Society
The president of the Royal Society (PRS), also known as the Royal Society of London, is the elected Head of the Royal Society who presides over meetings of the society's council.
After an informal meeting (a lecture) by Christopher Wren at Gresh ...
References
Further reading
* : "The Era of Todd, Plumb and Snow", by Sir
David Cannadine
Sir David Nicholas Cannadine (born 7 September 1950) is a British author and historian who specialises in modern history, Britain and the history of business and philanthropy. He is currently the Dodge Professor of History at Princeton Unive ...
The Independent
''The Independent'' is a British online newspaper. It was established in 1986 as a national morning printed paper. Nicknamed the ''Indy'', it began as a broadsheet and changed to tabloid format in 2003. The last printed edition was publis ...
The New York Times
''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of ...
''
* including the Nobel Lecture, 11 December 1957 ''Synthesis in the Study of Nucleotides''
*
*. Video of an interviewed with
Lewis Wolpert
Lewis Wolpert (19 October 1929 – 28 January 2021) was a South African-born British developmental biologist, author, and broadcaster. Wolpert popularized his French flag model of embryonic development, using the colours of the French flag ...
Churchill Archives Centre
The Churchill Archives Centre (CAC) at Churchill College at the University of Cambridge is one of the largest repositories in the United Kingdom for the preservation and study of modern personal papers. It is best known for housing the papers ...