Adelchi Negri (16 July 1876 – 19 February 1912) was an Italian

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

and

microbiologist A microbiologist (from Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of microscopic organisms such as bacteria, algae, fungi, and some types of par ...

born in

Perugia Perugia ( , ; ; ) is the capital city of Umbria in central Italy, crossed by the River Tiber. The city is located about north of Rome and southeast of Florence. It covers a high hilltop and part of the valleys around the area. It has 162,467 ...

. He studied medicine and

surgery Surgery is a medical specialty that uses manual and instrumental techniques to diagnose or treat pathological conditions (e.g., trauma, disease, injury, malignancy), to alter bodily functions (e.g., malabsorption created by bariatric surgery s ...

at the

University of Pavia The University of Pavia (, UNIPV or ''Università di Pavia''; ) is a university located in Pavia, Lombardy, Italy. There was evidence of teaching as early as 1361, making it one of the List of oldest universities in continuous operation, oldest un ...

, where he was a pupil of

Camillo Golgi Camillo Golgi (; 7 July 184321 January 1926) was an Italian biologist and pathologist known for his works on the central nervous system. He studied medicine at the University of Pavia (where he later spent most of his professional career) bet ...

(1843–1926). After graduation in 1900, he became an assistant to Golgi at his pathological institute. In 1909 Negri became a professor of

bacteriology Bacteriology is the branch and specialty of biology that studies the Morphology (biology), morphology, ecology, genetics and biochemistry of bacteria as well as many other aspects related to them. This subdivision of microbiology involves the iden ...

, and the first official instructor of bacteriology in

Pavia Pavia ( , ; ; ; ; ) is a town and comune of south-western Lombardy, in Northern Italy, south of Milan on the lower Ticino (river), Ticino near its confluence with the Po (river), Po. It has a population of c. 73,086. The city was a major polit ...

. On 19 February 1912 he died of

tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...

at age 35. Negri performed extensive research in the fields of

histology Histology, also known as microscopic anatomy or microanatomy, is the branch of biology that studies the microscopic anatomy of biological tissue (biology), tissues. Histology is the microscopic counterpart to gross anatomy, which looks at large ...

hematology Hematology (American and British English spelling differences#ae and oe, spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to bloo ...

cytology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...

, protozoology and

hygiene Hygiene is a set of practices performed to preserve health. According to the World Health Organization (WHO), "Hygiene refers to conditions and practices that help to maintain health and prevent the spread of diseases." Personal hygiene refer ...

. In 1903 he discovered the eponymous Negri bodies, defined as

cytoplasm The cytoplasm describes all the material within a eukaryotic or prokaryotic cell, enclosed by the cell membrane, including the organelles and excluding the nucleus in eukaryotic cells. The material inside the nucleus of a eukaryotic cell a ...

atic

inclusion bodies Inclusion bodies are aggregates of specific types of protein found in neurons, and a number of tissue (biology), tissue cells including red blood cells, bacteria, viruses, and plants. Inclusion bodies of aggregations of multiple proteins are also ...

located in the Purkinje cells of the

cerebellum The cerebellum (: cerebella or cerebellums; Latin for 'little brain') is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as it or eve ...

in cases of

rabies Rabies is a viral disease that causes encephalitis in humans and other mammals. It was historically referred to as hydrophobia ("fear of water") because its victims panic when offered liquids to drink. Early symptoms can include fever and abn ...

in animals and humans. He documented his findings in an article titled ''Contributo allo studio dell'eziologia della rabbia'', published in the journal ''Bollettino della Società medico-chirurgica''. At the time, Negri mistakenly described the pathological agent of rabies as a

parasitic Parasitism is a close relationship between species, where one organism, the parasite, lives (at least some of the time) on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The ent ...

protozoa Protozoa (: protozoan or protozoon; alternative plural: protozoans) are a polyphyletic group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic debris. Historically ...

. A few months later, Paul Remlinger (1871–1964) at the Constantinople Imperial Bacteriology Institute correctly demonstrated that the

aetiological Etiology (; alternatively spelled aetiology or ætiology) is the study of causation or origination. The word is derived from the Greek word ''()'', meaning "giving a reason for" (). More completely, etiology is the study of the causes, origins ...

agent of rabies was not a protozoan, but a filterable

virus A virus is a submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are ...

. Negri went on, however, to demonstrate in 1906 that the

smallpox vaccine The smallpox vaccine is used to prevent smallpox infection caused by the variola virus. It is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with th ...

, then known as "vaccine virus", or "variola vaccinae", was also a filterable virus.A. Negri, 'Ueber Filtration des Vaccinevirus', Z. Hyg. InfektKrankh., 1906, 54: 327-346, see pp. 332-333. During the latter part of his career, he became interested in

malaria Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomitin ...

and was at the forefront in efforts to eradicate it from

Lombardy The Lombardy Region (; ) is an administrative regions of Italy, region of Italy that covers ; it is located in northern Italy and has a population of about 10 million people, constituting more than one-sixth of Italy's population. Lombardy is ...

. In 1906 he married his colleague Lina Luzzani and six years later, at the age of thirty-five, died of tuberculosis.

Tomb

Negri was buried in the Monumental Cemetery of Pavia (Viale San Giovannino), along the central lane, on the left, near the tombs of other two important medical scientists, the anatomist

Bartolomeo Panizza Bartolomeo Panizza (August 17, 1785 – April 17, 1867) was an Italian anatomist born in Vicenza. He received a medical degree in surgery from Padua, and furthered his studies at Bologna and Pavia. In 1809 he became a professor at the University ...

and his teacher, the Nobel Prize–winning

References

Who Named It?, Adelchi Negri

Some places and memories related to Adelchi Negri
Italian microbiologists Italian pathologists University of Pavia alumni 1876 births 1912 deaths People from Perugia 20th-century deaths from tuberculosis Tuberculosis deaths in Italy {{microbiology-stub