Ada E. Yonath (, ; born 22 June 1939) is an Israeli crystallographer and Nobel laureate in Chemistry, best known for her pioneering work on the structure of

ribosome Ribosomes () are molecular machine, macromolecular machines, found within all cell (biology), cells, that perform Translation (biology), biological protein synthesis (messenger RNA translation). Ribosomes link amino acids together in the order s ...

s. She is the current director of the Helen and Milton A. Kimmelman Center for Biomolecular Structure and Assembly of the

Weizmann Institute of Science The Weizmann Institute of Science ( ''Machon Weizmann LeMada'') is a Public university, public research university in Rehovot, Israel, established in 1934, fourteen years before the State of Israel was founded. Unlike other List of Israeli uni ...

. In 2009, Yonath received the

Nobel Prize in Chemistry The Nobel Prize in Chemistry () is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outst ...

along with Venkatraman Ramakrishnan and Thomas A. Steitz for her studies on the structure and function of the ribosome, becoming the first Israeli woman to win the

Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...

out of ten Israeli Nobel laureates, the first woman from the Middle East to win a Nobel prize in the sciences, and the first woman in 45 years to win the Nobel Prize for Chemistry.

Biography

Ada Lifshitz (later Yonath) was born in the Geula quarter of

Jerusalem Jerusalem is a city in the Southern Levant, on a plateau in the Judaean Mountains between the Mediterranean Sea, Mediterranean and the Dead Sea. It is one of the List of oldest continuously inhabited cities, oldest cities in the world, and ...

. Her parents, Hillel and Esther Lifshitz, were

Zionist Zionism is an Ethnic nationalism, ethnocultural nationalist movement that emerged in History of Europe#From revolution to imperialism (1789–1914), Europe in the late 19th century that aimed to establish and maintain a national home for the ...

Jews Jews (, , ), or the Jewish people, are an ethnoreligious group and nation, originating from the Israelites of History of ancient Israel and Judah, ancient Israel and Judah. They also traditionally adhere to Judaism. Jewish ethnicity, rel ...

who immigrated to the British Mandate of Palestine (now

Israel Israel, officially the State of Israel, is a country in West Asia. It Borders of Israel, shares borders with Lebanon to the north, Syria to the north-east, Jordan to the east, Egypt to the south-west, and the Mediterranean Sea to the west. Isr ...

) from Zduńska Wola,

Poland Poland, officially the Republic of Poland, is a country in Central Europe. It extends from the Baltic Sea in the north to the Sudetes and Carpathian Mountains in the south, bordered by Lithuania and Russia to the northeast, Belarus and Ukrai ...

in 1933 before the establishment of

. (In this source the surname is spelled ''Livshitz'') Her father was a

rabbi A rabbi (; ) is a spiritual leader or religious teacher in Judaism. One becomes a rabbi by being ordained by another rabbi—known as ''semikha''—following a course of study of Jewish history and texts such as the Talmud. The basic form of t ...

and came from a rabbinical family. They settled in Jerusalem and ran a grocery, but found it difficult to make ends meet. They lived in cramped quarters with several other families, and Yonath remembers "books" being the only thing she had to keep her occupied. Despite their poverty, her parents sent her to school in the upscale Beit HaKerem neighborhood to assure her a good education. When her father died at the age of 42, the family moved to

Tel Aviv Tel Aviv-Yafo ( or , ; ), sometimes rendered as Tel Aviv-Jaffa, and usually referred to as just Tel Aviv, is the most populous city in the Gush Dan metropolitan area of Israel. Located on the Israeli Mediterranean coastline and with a popula ...

. Yonath was accepted to Tichon Hadash high school although her mother could not pay the tuition. She gave math lessons to students in return. As a youngster, she says she was inspired by the Polish and naturalized-French scientist

Marie Curie Maria Salomea Skłodowska-Curie (; ; 7 November 1867 – 4 July 1934), known simply as Marie Curie ( ; ), was a Polish and naturalised-French physicist and chemist who conducted pioneering research on radioactivity. She was List of female ...

. However, she stresses that Curie, whom she as a child was fascinated by after reading her biography, was not her "role model". She returned to Jerusalem for college, graduating from the

Hebrew University of Jerusalem The Hebrew University of Jerusalem (HUJI; ) is an Israeli public university, public research university based in Jerusalem. Co-founded by Albert Einstein and Chaim Weizmann in July 1918, the public university officially opened on 1 April 1925. ...

with a bachelor's degree in

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...

in 1962, and a master's degree in

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

in 1964. In 1968, she obtained her PhD from the

for X-ray crystallographic studies on the structure of

collagen Collagen () is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, making up 25% to 35% of protein content. Amino acids are bound together to form a trip ...

, with Wolfie Traub as her PhD advisor. She has one daughter, Hagit Yonath, a doctor at Sheba Medical Center, and a granddaughter, Noa. She is the cousin of anti-occupation activist Ruchama Marton.

Scientific career

Ada Yonath Weizmann Institute of Science

Yonath accepted postdoctoral positions at

Carnegie Mellon University Carnegie Mellon University (CMU) is a private research university in Pittsburgh, Pennsylvania, United States. The institution was established in 1900 by Andrew Carnegie as the Carnegie Technical Schools. In 1912, it became the Carnegie Institu ...

(1969) and

MIT The Massachusetts Institute of Technology (MIT) is a private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and sc ...

(1970). While a postdoc at MIT she spent some time in the lab of subsequent 1976 chemistry Nobel Prize winner William N. Lipscomb, Jr. of

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

where she was inspired to pursue very large structures. In 1970, she established what was for nearly a decade the only

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

crystallography laboratory in Israel. Then, from 1979 to 1984 she was a group leader with Heinz-Günter Wittmann at the Max Planck Institute for Molecular Genetics in Berlin. She was a visiting professor at the

University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...

in 1977–78. She headed a

Max-Planck Institute The Max Planck Society for the Advancement of Science (; abbreviated MPG) is a formally independent non-governmental and non-profit association of German research institutes. Founded in 1911 as the Kaiser Wilhelm Society, it was renamed to the M ...

Research Unit at

DESY DESY, short for Deutsches Elektronen-Synchrotron (English: ''German Electron Synchrotron''), is a national research centre for fundamental science located in Hamburg and Zeuthen near Berlin in Germany. It operates particle accelerators used to ...

Hamburg Hamburg (, ; ), officially the Free and Hanseatic City of Hamburg,. is the List of cities in Germany by population, second-largest city in Germany after Berlin and List of cities in the European Union by population within city limits, 7th-lar ...

, Germany (1986–2004) in parallel to her research activities at the Weizmann Institute. Yonath focuses on the mechanisms underlying

protein biosynthesis Protein biosynthesis, or protein synthesis, is a core biological process, occurring inside Cell (biology), cells, homeostasis, balancing the loss of cellular proteins (via Proteolysis, degradation or Protein targeting, export) through the produc ...

, by ribosomal crystallography, a research line she pioneered over twenty years ago despite considerable skepticism of the international scientific community. Ribosomes translate

RNA Ribonucleic acid (RNA) is a polymeric molecule that is essential for most biological functions, either by performing the function itself (non-coding RNA) or by forming a template for the production of proteins (messenger RNA). RNA and deoxyrib ...

into protein and because they have slightly different structures in microbes, when compared to

eukaryote The eukaryotes ( ) constitute the Domain (biology), domain of Eukaryota or Eukarya, organisms whose Cell (biology), cells have a membrane-bound cell nucleus, nucleus. All animals, plants, Fungus, fungi, seaweeds, and many unicellular organisms ...

s, such as human cells, they are often a target for antibiotics. In 2000 and 2001, she determined the complete high-resolution structures of both ribosomal subunits and discovered within the otherwise asymmetric ribosome, the universal symmetrical region that provides the framework and navigates the process of polypeptide polymerization. Consequently, she showed that the ribosome is a

ribozyme Ribozymes (ribonucleic acid enzymes) are RNA molecules that have the ability to Catalysis, catalyze specific biochemical reactions, including RNA splicing in gene expression, similar to the action of protein enzymes. The 1982 discovery of ribozy ...

that places its substrates in

stereochemistry Stereochemistry, a subdiscipline of chemistry, studies the spatial arrangement of atoms that form the structure of molecules and their manipulation. The study of stereochemistry focuses on the relationships between stereoisomers, which are defined ...

suitable for

peptide bond In organic chemistry, a peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one) of one alpha-amino acid and N2 (nitrogen number two) of another, along a peptide or protein cha ...

formation and for substrate-mediated

catalysis Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quick ...

. In 1993 she visualized the path taken by the nascent proteins, namely the ribosomal tunnel, and recently revealed the dynamics elements enabling its involvement in elongation arrest, gating, intra-cellular regulation and nascent chain trafficking into their folding space. Additionally, Yonath elucidated the modes of action of over twenty different

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

s targeting the ribosome, illuminated mechanisms of

drug resistance Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. The term is used in the context of resistance that pathogens or cancers have "acquired", that is ...

and

synergism In Christian theology, synergism refers to the cooperative effort between God and humanity in the process of Salvation in Christianity, salvation. Before Augustine of Hippo (354–430), synergism was almost universally endorsed. Later, it came to ...

, deciphered the structural basis for antibiotic selectivity and showed how it plays a key role in clinical usefulness and therapeutic effectiveness, thus paving the way for structure-based

drug design Drug design, often referred to as rational drug design or simply rational design, is the invention, inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic compound, organi ...

. For enabling ribosomal crystallography Yonath introduced a novel technique, cryo bio-crystallography, which became routine in structural biology and allowed intricate projects otherwise considered formidable. At the Weizmann Institute, Yonath is the incumbent of the Martin S. and Helen Kimmel Professorial Chair.

Political Views

She has called for the unconditional release of all Palestinian prisoners, saying that "holding Palestinians captive encourages and perpetuates their motivation to harm Israel and its citizens ... once we don't have any prisoners to release they will have no reason to kidnap soldiers".

Awards and recognition

Yonath is a member of the

United States National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

; the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

; the Israel Academy of Sciences and Humanities; the European Academy of Sciences and Art and the European Molecular Biology Organization. On Saturday, 18 October 2014, Professor Yonath was named an ordinary member of the Pontifical Academy of Sciences by

Pope Francis Pope Francis (born Jorge Mario Bergoglio; 17 December 1936 – 21 April 2025) was head of the Catholic Church and sovereign of the Vatican City State from 13 March 2013 until Death and funeral of Pope Francis, his death in 2025. He was the fi ...

. Her awards and honors include the following: * In 2002,

Israel Prize The Israel Prize (; ''pras israél'') is an award bestowed by the State of Israel, and regarded as the state's highest cultural honor. History Prior to the Israel Prize, the most significant award in the arts was the Dizengoff Prize and in Israel ...

* In 2002,

Harvey Prize The Harvey Prize is an annual Israeli award for breakthroughs in science and technology, as well as contributions to peace in the Middle East granted by the Technion – Israel Institute of Technology, Technion in Haifa. The prize has become a ...

* In 2004, Massry Prize * In 2004, Paul Karrer Gold Medal * In 2005,

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemist ...

* In 2006, Wolf Prize in Chemistry along with George Feher. * In 2006,

Rothschild Prize Yad Hanadiv (The Rothschild Foundation) is a Rothschild family philanthropic foundation in Israel. Goals and objectives Yad Hanadiv defines its mission as: Dedicated to creating resources for advancing Israel as a healthy, vibrant, democratic so ...

Life Sciences This list of life sciences comprises the branches of science that involve the scientific study of life – such as microorganisms, plants, and animals including human beings. This science is one of the two major branches of natural science, ...

. * In 2006, The EMET Prize for Art, Science and Culture in Life Sciences, along with Professor Peretz Lavie (Medicine) and Professor Eli Keshet (Biology) * In 2007,

Paul Ehrlich and Ludwig Darmstaedter Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for research in medicine. It carries a monetary prize of 120,000 Euro. The prize ceremony is traditionally held on the 14th of March, the birthday of Nob ...

along with Harry Noller * In 2008, the

Albert Einstein World Award of Science The Albert Einstein World Award for Science is an annual award given by the World Cultural Council "as a means of recognition and encouragement for scientific and technological research and development", with special consideration for researche ...

for her pioneering contributions to protein biosynthesis in the field of ribosomal crystallography and her introduction of innovative techniques in cryo bio-crystallography. * In 2009, the

(co-recipient with Thomas Steitz and Venkatraman Ramakrishnan). She was the first Israeli woman to be awarded a

. * In 2010,

Wilhelm Exner Medal The Wilhelm Exner Medal has been awarded by the Austrian Industry Association, (ÖGV), for excellence in research and science since 1921. The medal is dedicated to Wilhelm Exner (1840–1931), former president of the Association, who initialize ...

* In 2011, Marie Curie Medal awarded by the Polish Chemical Society * In 2013 she became a member of the

German Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (), in short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on 1 January 1652, based on academic models in Italy, it was originally named the ''Academi ...

. * In 2015, she was awarded Honorary Doctorates from the

University of Southern California The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in ...

, the De La Salle University, Manila/Philippines; the Joseph Fourier University, Grenoble/France; the Medical University of Lodz, Lodz/Poland; and the University of Warwick, UK. * In 2018, she was awarded an Honorary Doctorate from

* In 2020, she was elected a

Foreign Member of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

* In 2023, she was awarded an Honorary Doctorate from the

Jagiellonian University The Jagiellonian University (, UJ) is a public research university in Kraków, Poland. Founded in 1364 by Casimir III the Great, King Casimir III the Great, it is the oldest university in Poland and one of the List of oldest universities in con ...

. * In 2024, she was awarded an Honorary Doctorate from the Technion.

References

External links

"APS user shares the “Israeli Nobel” for chemistry"
from the

Argonne National Laboratory Argonne National Laboratory is a Federally funded research and development centers, federally funded research and development center in Lemont, Illinois, Lemont, Illinois, United States. Founded in 1946, the laboratory is owned by the United Sta ...

Advanced Photon Source (APS),

United States Department of Energy The United States Department of Energy (DOE) is an executive department of the U.S. federal government that oversees U.S. national energy policy and energy production, the research and development of nuclear power, the military's nuclear w ...