R06A Antihistamines for systemic use

R06AA Aminoalkyl ethers

:R06AA01 Bromazine :R06AA02

Diphenhydramine Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. Although generally considered sedating, diphenhydramine can cause paradoxical central nervous system stimulation in some individuals, particula ...

:R06AA04

Clemastine Clemastine, also known as meclastin, is a first-generation H1 histamine antagonist (antihistamine) with anticholinergic properties (drying) and sedative side effects. Like all first-generation antihistamines, it is sedating. Patented in 1960 ...

:R06AA06

Chlorphenoxamine Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is an analog of diphenhydramine Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamin ...

:R06AA07

Diphenylpyraline Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the benzhydryl, diphenylpiperidine class. It is marketed ...

:R06AA08

Carbinoxamine Carbinoxamine is an antihistamine and anticholinergic agent. It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antag ...

:R06AA09

Doxylamine Doxylamine is an antihistamine medication used to treat insomnia and allergies, and—in combination with pyridoxine ( vitamin B6)—to treat morning sickness in pregnant women. It is available over-the-counter and is sold under such brand names ...

:R06AA10

Trimethobenzamide Trimethobenzamide (trade names Tebamide, Tigan) is an antiemetic used to prevent nausea and vomiting. Mechanism of action Trimethobenzamide is an antagonist of the D2 receptor. It is believed to affect the chemoreceptor trigger zone (CTZ) of ...

:R06AA11

Dimenhydrinate Dimenhydrinate, also known as diphenhydramine/8-chlorotheophylline salt and sold under the brand names Dramamine and Gravol, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theocl ...

:R06AA52 Diphenhydramine, combinations :R06AA54 Clemastine, combinations :R06AA56 Chlorphenoxamine, combinations :R06AA57 Diphenylpyraline, combinations :R06AA59 Doxylamine, combinations :R06AA61 Dimenhydrinate, combinations

R06AB Substituted alkylamines

:R06AB01

Brompheniramine Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class. It is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such ...

:R06AB02

Dexchlorpheniramine Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of chlorpheniramine. It ...

:R06AB03 Dimetindene :R06AB04

Chlorphenamine Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever). It is taken orally (by mouth). The medication takes effect within two hours ...

:R06AB05

Pheniramine Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an ...

:R06AB06

Dexbrompheniramine Dexbrompheniramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in comb ...

:R06AB07 Talastine :R06AB51 Brompheniramine, combinations :R06AB52 Dexchlorpheniramine, combinations :R06AB54 Chlorphenamine, combinations :R06AB56 Dexbrompheniramine, combinations

R06AC Substituted ethylene diamines

:R06AC01

Mepyramine Mepyramine, also known as pyrilamine, is a first-generation antihistamine, targeting the H1 receptor as an inverse agonist. Mepyramine rapidly permeates the brain, often causing drowsiness. It is often sold as a maleate salt, pyrilamine maleat ...

:R06AC02 Histapyrrodine :R06AC03

Chloropyramine Chloropyramine is a first-generation H1 antagonist, antihistamine drug approved in several Eastern European countries such as Russia for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) ...

:R06AC04

Tripelennamine Tripelennamine, sold under the brand name Pyribenzamine by Novartis, is a drug that is used as an antipruritic and first-generation antihistamine. It can be used in the treatment of asthma, hay fever, rhinitis, and urticaria, but is now less ...

:R06AC05

Methapyrilene Methapyrilene is an antihistamine and anticholinergic of the pyridine chemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK. It has relatively strong sedative effects, to the ...

:R06AC06

Thonzylamine Thonzylamine (or neohetramine) is an antihistamine and anticholinergic used as an antipruritic. Synthesis See also *Zolamine Zolamine is an antihistamine and anticholinergic used as an antipruritic Antipruritics, abirritants, or anti-itch ...

:R06AC52 Histapyrrodine, combinations :R06AC53 Chloropyramine, combinations

R06AD Phenothiazine derivatives

:R06AD01 Alimemazine :R06AD02

Promethazine Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, sedative, and antiemetic used to treat allergies, insomnia, and nausea. It may also help with some symptoms associated with the common cold a ...

:R06AD03

Thiethylperazine Thiethylperazine (Torecan, Norzine) is an antiemetic of the phenothiazine class. It is an antagonist of dopamine receptors (Dopamine receptor D1, DRD1, Dopamine receptor D2, DRD2, Dopamine receptor D4, DRD4) as well as of 5-HT2A receptor, 5-HT2A, ...

:R06AD04 Methdilazine :R06AD05 Hydroxyethylpromethazine :R06AD06 Thiazinam :R06AD07 Mequitazine :R06AD08 Oxomemazine :R06AD09

Isothipendyl Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic. In the 2020s, at least, it is rarely used in the first line relief of allergies due to the anticholinergic side effect of somnolence bu ...

:R06AD52 Promethazine, combinations :R06AD55 Hydroxyethylpromethazine, combinations

R06AE Piperazine derivatives

:R06AE01

Buclizine Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine. In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, market ...

:R06AE03

Cyclizine Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. It may also be used for nausea after general anaesthesia or that which developed from opio ...

:R06AE04

Chlorcyclizine Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries. It is used primarily to treat allergy symptoms su ...

:R06AE05 Meclozine :R06AE06 Oxatomide :R06AE07

Cetirizine Cetirizine is a second-generation antihistamine, second-generation Peripherally selective antihistamine used to treat allergic rhinitis (hay fever), dermatitis, and urticaria (hives). It is taken by mouth. Effects generally begin within thirty ...

:R06AE09

Levocetirizine Levocetirizine, sold under the brand name Xyzal, among others, is a second-generation antihistamine used for the treatment of allergic rhinitis (hay fever) and long-term hives of unclear cause. It is less sedating than older antihistamines. ...

:R06AE51 Buclizine, combinations :R06AE53 Cyclizine, combinations :R06AE55 Meclozine, combinations

R06AK Combinations of antihistamines

:''Empty group''

R06AX Other antihistamines for systemic use

:R06AX01 Bamipine :R06AX02

Cyproheptadine Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine, first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 a ...

:R06AX03

Thenalidine Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia Neutropenia is an abnormally low concentration of neutr ...

:R06AX04

Phenindamine Phenindamine (Nolahist, Thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine. It was developed by Hoffman-La Roche in the late 1940s. It is used to treat symptoms of the common cold and allergies, such as sneezing, ...

:R06AX05 Antazoline :R06AX07

Triprolidine Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-lik ...

:R06AX08 Pyrrobutamine :R06AX09

Azatadine Azatadine (Optimine) is a first-generation antihistamine and anticholinergic drug that was synthesized in 1963 by Schering-Plough, a former American pharmaceutical company. It was patented in 1967. It has been succeeded by both loratadine and ...

:R06AX11

Astemizole Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It was withdrawn from the ma ...

:R06AX12

Terfenadine Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi) and was marketed under various brand names, including Seldane in the United States, Triluda ...

:R06AX13

Loratadine Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. This includes allergic rhinitis (hay fever) and hives. It is also available in drug combinations such as loratadine/pseudoephedrine, in whic ...

:R06AX15 Mebhydrolin :R06AX16 Deptropine :R06AX17

Ketotifen Ketotifen is an antihistamine medication and a mast cell stabilizer used to treat allergic conditions such as conjunctivitis, asthma, and urticaria (hives). Ketotifen is available in ophthalmic (eye drops or drug-eluting contact lenses) and o ...

:R06AX18

Acrivastine Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors. This non-sedating ...

:R06AX19

Azelastine Azelastine, sold under the brand name Astelin among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis (hay fever) and as eye drops for allergic conjunctivitis. Other uses may include asth ...

:R06AX21 Tritoqualine :R06AX22

Ebastine Ebastine is a H1 antihistamine with low potential for causing drowsiness. It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H1 receptor in peripheral tissue with a low incid ...

:R06AX23 Pimethixene :R06AX24 Epinastine :R06AX25

Mizolastine Mizolastine (Mizollen) is a once-daily, non-sedating antihistamine. It blocks H1 receptors and is commonly fast-acting. It does not prevent the actual release of histamine from mast cell A mast cell (also known as a mastocyte or a labrocyte ...

:R06AX26

Fexofenadine Fexofenadine, sold under the brand name Allegra among others, is an antihistamine medication used in the treatment of allergy symptoms such as allergic rhinitis and urticaria. Therapeutically, fexofenadine is a selective peripheral H1 blocke ...

:R06AX27

Desloratadine Desloratadine sold under the brand name Aerius among others, is a tricyclic H1 antagonist, H1 inverse agonist that is used to treat allergy, allergies. It is an active metabolite of loratadine. It was patented in 1984 and came into medical u ...

:R06AX28

Rupatadine Rupatadine is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies. It was discovered and developed by and is marketed as Rupafin and under several other trade names. Medical uses Rupatadine fu ...

:R06AX29

Bilastine Bilastine is an antihistamine medication used to treat hives (urticaria), allergic rhinitis and itchy inflamed eyes (allergic conjunctivitis) caused by an allergy. It is a second-generation antihistamine and takes effect by selectively inhibi ...

:R06AX31 Quifenadine :R06AX32 Sequifenadine :R06AX53 Thenalidine, combinations :R06AX58 Pyrrobutamine, combinations

References

{{Antihistamines R06