N05A
Antipsychotic Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), p ...
s

N05AA Phenothiazines with aliphatic side-chain

:N05AA01

Chlorpromazine Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar d ...

:N05AA02

Levomepromazine Levomepromazine, also known as methotrimeprazine, is a phenothiazine neuroleptic drug. Brand names include Nozinan, Levoprome, Detenler, Hirnamin, Levotomin and Neurocil. It is a low-potency antipsychotic (approximately half as potent as chlorp ...

:N05AA03 Promazine :N05AA04 Acepromazine :N05AA05 Triflupromazine :N05AA06 Cyamemazine :N05AA07 Chlorproethazine

N05AB Phenothiazines with
piperazine Piperazine () is an organic compound with the formula . In term of its structure, it can be described as cyclohexane with the 1- and 4-CH2 groups replaced by NH. Piperazine exists as deliquescent solid with a saline taste. Piperazine is freely sol ...
structure

:N05AB01 Dixyrazine :N05AB02 Fluphenazine :N05AB03 Perphenazine :N05AB04 Prochlorperazine :N05AB05 Thiopropazate :N05AB06 Trifluoperazine :N05AB07 Acetophenazine :N05AB08 Thioproperazine :N05AB09 Butaperazine :N05AB10 Perazine

N05AC Phenothiazines with
piperidine Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor de ...
structure

:N05AC01

Periciazine Periciazine ( INN), also known as pericyazine ( BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics. Periciazine is not approved for sale in the United States. It is commonly sold in Canada, Ital ...

:N05AC02

Thioridazine Thioridazine (Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwid ...

:N05AC03 Mesoridazine :N05AC04 Pipotiazine

N05AD
Butyrophenone Butyrophenone is an organic compound with the formula C6H5C(O)C3H7. It is a colorless liquid. The butyrophenone structure—a ketone flanked by a phenyl ring and a butyl chain—forms the basis for many other chemicals containing various subst ...
derivatives

:N05AD01

Haloperidol Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychos ...

:N05AD02 Trifluperidol :N05AD03 Melperone :N05AD04

Moperone Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia. It is an antagonist An antagonist is a character in a story who is presented as the ...

:N05AD05 Pipamperone :N05AD06 Bromperidol :N05AD07

Benperidol Benperidol, sold under the trade name Anquil among others, is a typical antipsychotic primarily used to treat hypersexuality syndromes and can be used to treat schizophrenia. It is a highly potent butyrophenone derivative and is the most potent ...

:N05AD08

Droperidol Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar fentanyl.html" ;"title="ombination with fentanyl">ombination with fentanyl is an antidopaminergic medication, drug used as an antiemetic (that is, to prevent or treat nausea) and as an ...

:N05AD09 Fluanisone :N05AD10 Lumateperone :QN05AD90

Azaperone Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. It is uncommonly used in humans as an antipsychotic drug. Azaperone acts ...

N05AE
Indole Indole is an organic compound with the formula . Indole is classified as an aromatic heterocycle. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indoles are derivatives of indole ...
derivatives

:N05AE01 Oxypertine :N05AE02 Molindone :N05AE03 Sertindole :N05AE04 Ziprasidone :N05AE05 Lurasidone

N05AF
Thioxanthene Thioxanthene is a chemical compound in which the oxygen atom in xanthene is replaced with a sulfur atom. It is also related to phenothiazine. Several of its chemical derivative, derivatives are used as typical antipsychotics in the treatment of sc ...
derivatives

:N05AF01 Flupentixol :N05AF02

Clopenthixol Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961. Clopenthixol is a mixture of '' cis'' and ''trans'' isomers. Zuclopenthixol, the pure ''cis'' ...

:N05AF03

Chlorprothixene Chlorprothixene, sold under the brand name Truxal among others, is a typical antipsychotic of the thioxanthene group. Medical uses Chlorprothixene's principal indications are the treatment of psychotic disorders (e.g. schizophrenia) and of acut ...

:N05AF04

Thiothixene Tiotixene, or thiothixene is a typical antipsychotic agent currently sold under the brand name Navane which is predominantly utilised to treat acute and chronic schizophrenia. Beyond its primary Indication (medicine), indication, it can exhibit ...

:N05AF05

Zuclopenthixol Zuclopenthixol (brand names Cisordinol, Clopixol and others), also known as zuclopentixol, is a medication used to treat schizophrenia and other psychoses. It is classed, pharmacologically, as a typical antipsychotic. Chemically it is a thioxant ...

N05AG Diphenylbutylpiperidine derivatives

:N05AG01 Fluspirilene :N05AG02

Pimozide Pimozide (sold under the brand name Orap) is a neuroleptic medication, drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weigh ...

:N05AG03

Penfluridol Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and flusp ...

N05AH Diazepines, oxazepines, thiazepines and oxepines

:N05AH01 Loxapine :N05AH02

Clozapine Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. It is used primarily to treat people with schizophrenia and schizoaffective disorder who have ...

:N05AH03

Olanzapine Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. It is also sometimes used off-label for treatment of chemotherapy-induced nausea and vomitin ...

:N05AH04 Quetiapine :N05AH05

Asenapine Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder. I ...

:N05AH06 Clotiapine :N05AH53 Olanzapine and samidorphan

N05AL
Benzamide Benzamide is an organic compound with the chemical formula of C7H7NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid, while in crystalline form, it appears as colourless crystals. It is slightly ...
s

:N05AL01

Sulpiride Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic) medication of the benzamide class which is used mainly in the treatment of psychosi ...

:N05AL02 Sultopride :N05AL03 Tiapride :N05AL04 Remoxipride :N05AL05

Amisulpride Amisulpride, sold under the brand names Socian and Barhemsys, is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting. It is specifically used at lower doses intravenously to prev ...

:N05AL06 Veralipride :N05AL07 Levosulpiride

N05AN
Lithium Lithium (from , , ) is a chemical element; it has chemical symbol, symbol Li and atomic number 3. It is a soft, silvery-white alkali metal. Under standard temperature and pressure, standard conditions, it is the least dense metal and the ...

:N05AN01

Lithium Lithium (from , , ) is a chemical element; it has chemical symbol, symbol Li and atomic number 3. It is a soft, silvery-white alkali metal. Under standard temperature and pressure, standard conditions, it is the least dense metal and the ...

N05AX Other antipsychotics

:N05AX07 Prothipendyl :N05AX08

Risperidone Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder, as well as aggressive and self-injurious behaviors associated with autism spectrum disorder. It is t ...

:N05AX10 Mosapramine :N05AX11 Zotepine :N05AX12

Aripiprazole Aripiprazole, sold under the brand name Abilify, among others, is an atypical antipsychotic primarily used in the treatment of schizophrenia, bipolar disorder, and irritability associated with autism spectrum disorder; other uses include as ...

:N05AX13 Paliperidone :N05AX14 Iloperidone :N05AX15

Cariprazine Cariprazine, sold under the brand name Vraylar among others, is an atypical antipsychotic developed by Gedeon Richter, which is used in the treatment of schizophrenia and bipolar disorder. It is also prescribed as an add-on treatment for bip ...

:N05AX16 Brexpiprazole :N05AX17 Pimavanserin :QN05AX90 Amperozide

N05B
Anxiolytic An anxiolytic (; also antipanic or anti-anxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxie ...
s

N05BA
Benzodiazepine Benzodiazepines (BZD, BDZ, BZs), colloquially known as "benzos", are a class of central nervous system (CNS) depressant, depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed t ...
derivatives

:N05BA01

Diazepam Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is used to treat a range of conditions, including anxiety disorder, anxiety, seizures, alcohol withdrawal syndr ...

:N05BA02

Chlordiazepoxide Chlordiazepoxide hydrochloride, sold under the brand name Librium is a sedative and hypnotic medication of the benzodiazepine class. It is used to treat anxiety, insomnia and symptoms of withdrawal from alcohol, benzodiazepines, and other drug ...

:N05BA03 Medazepam :N05BA04

Oxazepam Oxazepam is a short-to-intermediate-acting benzodiazepine. Oxazepam is used for the treatment of anxiety, insomnia, and to control symptoms of alcohol withdrawal syndrome. It is a metabolite of diazepam, prazepam, and temazepam, and has moderate ...

:N05BA05 Potassium clorazepate :N05BA06

Lorazepam Lorazepam, sold under the brand name Ativan, Tavor among others, is a benzodiazepine medication. It is used to treat anxiety (including anxiety disorders), insomnia, severe agitation, active seizures including status epilepticus, alcoh ...

:N05BA07 Adinazolam :N05BA08

Bromazepam Bromazepam, sold under many brand names, is a benzodiazepine. It is mainly an anxiolytic, anti-anxiety agent with similar side effects to diazepam. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedica ...

:N05BA09

Clobazam Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968. Clobazam was first synthesized in 1966 and first published in 1969. Clobazam was originally marketed as an anxiosele ...

:N05BA10 Ketazolam :N05BA11

Prazepam Prazepam is a benzodiazepine Benzodiazepines (BZD, BDZ, BZs), colloquially known as "benzos", are a class of central nervous system (CNS) depressant, depressant drugs whose core chemical structure is the fusion of a benzene ring and a diaz ...

:N05BA12

Alprazolam Alprazolam, sold under the brand name Xanax among others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. Alprazolam is most commonly prescribed in the ...

:N05BA13 Halazepam :N05BA14 Pinazepam :N05BA15 Camazepam :N05BA16 Nordazepam :N05BA17 Fludiazepam :N05BA18 Ethyl loflazepate :N05BA19 Etizolam :N05BA21

Clotiazepam Clotiazepam (marketed under brand name Clozan, Distensan, Trecalmo, Rize, Rizen and Veratran) is a thienodiazepine drug which is a benzodiazepine analog. The clotiazepam molecule differs from benzodiazepines in that the benzene ring has been r ...

:N05BA22 Cloxazolam :N05BA23 Tofisopam :N05BA24 Bentazepam :N05BA25 Mexazolam :N05BA56 Lorazepam, combinations

N05BB Diphenylmethane derivatives

:N05BB01 Hydroxyzine :N05BB02 Captodiame :N05BB51 Hydroxyzine, combinations

N05BC
Carbamate In organic chemistry, a carbamate is a category of organic compounds with the general Chemical formula, formula and Chemical structure, structure , which are formally Derivative (chemistry), derived from carbamic acid (). The term includes orga ...
s

:N05BC01

Meprobamate Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benz ...

:N05BC03 Emylcamate :N05BC04 Mebutamate :N05BC51 Meprobamate, combinations

N05BD Dibenzo-bicyclo-octadiene derivatives

:N05BD01 Benzoctamine

N05BE Azaspirodecanedione derivatives

:N05BE01

Buspirone Buspirone, sold under the brand name Buspar among others, is an anxiolytic, a medication primarily used to treat anxiety disorders, particularly generalized anxiety disorder (GAD). It is a serotonin 5-HT1A receptor, 5-HT1A receptor partial ag ...

N05BX Other anxiolytics

:N05BX01 Mephenoxalone :N05BX02 Gedocarnil :N05BX03 Etifoxine :N05BX04 Fabomotizole :N05BX05 Lavandulae aetheroleum

N05C
Hypnotic A hypnotic (from Ancient Greek, Greek ''Hypnos'', sleep), also known as a somnifacient or soporific, and commonly known as sleeping pills, are a class of psychoactive drugs whose primary function is to sleep induction, induce sleep and to trea ...
s and
sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its decelera ...
s

N05CA Barbiturates, plain

:N05CA01

Pentobarbital Pentobarbital (US) or pentobarbitone (British and Australian) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions in emergencies. It can also be used for short-term treatment of insomnia but ...

:N05CA02

Amobarbital Amobarbital (formerly known as amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. ...

:N05CA03 Butobarbital :N05CA04 Barbital :N05CA05 Aprobarbital :N05CA06

Secobarbital Secobarbital, sold under the brand name Seconal among others, is a short-acting barbiturate drug originally used for the treatment of insomnia. It was patented by Eli Lilly and Company in 1934 in the United States. It possesses anesthetic, antic ...

:N05CA07 Talbutal :N05CA08 Vinylbital :N05CA09 Vinbarbital :N05CA10 Cyclobarbital :N05CA11 Heptabarbital :N05CA12 Reposal :N05CA15

Methohexital Methohexital or methohexitone (marketed under the brand names Brevital and Brietal) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. It is similar in its effects to sodium thiopental ...

:N05CA16 Hexobarbital :N05CA19 Thiopental :N05CA20 Ethallobarbital :N05CA21 Allobarbital :N05CA22 Proxibarbal

N05CB Barbiturates, combinations

:N05CB01 Combinations of barbiturates :N05CB02 Barbiturates in combination with other drugs

N05CC Aldehydes and derivatives

:N05CC01

Chloral hydrate Chloral hydrate is a geminal diol with the formula . It was first used as a sedative and hypnotic in Germany in the 1870s. Over time it was replaced by safer and more effective alternatives but it remained in use in the United States until at ...

:N05CC02 Chloralodol :N05CC03 Acetylglycinamide chloral hydrate :N05CC04 Dichloralphenazone :N05CC05

Paraldehyde Paraldehyde is the cyclic trimer (chemistry), trimer of acetaldehyde molecules. Formally, it is a derivative of 1,3,5-trioxane, with a methyl group substituted for a hydrogen atom at each carbon. The corresponding tetramer is metaldehyde. A colo ...

N05CD Benzodiazepine derivatives

:N05CD01 Flurazepam :N05CD02

Nitrazepam Nitrazepam, sold under the brand name Mogadon among others, is a Hypnotic, hypnotic drug of the benzodiazepine class used for short-term relief from severe, disabling anxiety and insomnia. It also has sedative (calming) properties, as well as am ...

:N05CD03 Flunitrazepam :N05CD04 Estazolam :N05CD05

Triazolam Triazolam, sold under the brand name Halcion among others, is a central nervous system (CNS) depressant tranquilizer of the triazolobenzodiazepine (TBZD) class, which are benzodiazepine (BZD) derivatives. It possesses pharmacological properti ...

:N05CD06 Lormetazepam :N05CD07

Temazepam Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. It is taken by mouth. Temazepam is rapidly absorbed, and significant hypn ...

:N05CD08

Midazolam Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia, premedication before surgical anesthesia, and procedural sedation, and to treat psychomotor agitation, severe agitation. It induces ...

:N05CD09 Brotizolam :N05CD10 Quazepam :N05CD11 Loprazolam :N05CD12 Doxefazepam :N05CD13 Cinolazepam :N05CD14 Remimazolam :N05CD15

Nimetazepam Nimetazepam (marketed under brand name Erimin and Lavol) is an intermediate-acting hypnotic drug which is a benzodiazepine derivative. It was first synthesized by a team at Hoffmann-La Roche in 1964. It possesses powerful hypnotic, anxiolytic ...

:QN05CD90 Climazolam

N05CE Piperidinedione derivatives

:N05CE01

Glutethimide Glutethimide (brand names included Doriden, Elrodorm, and Noxyrom) is a central nervous system (CNS) depressant drug of the piperidine chemical class, one of many non-barbiturate, "barbiturate-like" GABAergic medications exhibiting general calm ...

:N05CE02 Methyprylon :N05CE03 Pyrithyldione

N05CF Benzodiazepine related drugs

:N05CF01

Zopiclone Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine, specifically a cyclopyrrolone, used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone ...

:N05CF02

Zolpidem Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and after beh ...

:N05CF03

Zaleplon Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. It was developed by King Pharmaceuticals and approved fo ...

:N05CF04

Eszopiclone Eszopiclone, sold under the brand name Lunesta among others, is a nonbenzodiazepine medication used in the treatment of short-term and long-term insomnia. It holds the distinction of being one of the few FDA-approved hypnotic medications with ...

N05CH Melatonin receptor agonists

:N05CH01

Melatonin Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cow ...

:N05CH02

Ramelteon Ramelteon, sold under the brand name Rozerem among others, is a melatonin agonist medication which is used in the treatment of insomnia. It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset. ...

:N05CH03 Tasimelteon

N05CJ Orexin receptor antagonists

:N05CJ01 Suvorexant :N05CJ02 Lemborexant :N05CJ03 Daridorexant

N05CM Other hypnotics and sedatives

:N05CM01

Methaqualone Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude ( ) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg me ...

:N05CM02 Clomethiazole :N05CM03 Bromisoval :N05CM04 Carbromal :N05CM05

Scopolamine Scopolamine, also known as hyoscine, or Devil's Breath, is a medication used to treat motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva. When used by injection, effects begin a ...

:N05CM06 Propiomazine :N05CM07 Triclofos :N05CM08 Ethchlorvynol :N05CM09 Valerianae radix :N05CM10 Hexapropymate :N05CM11

Bromide A bromide ion is the negatively charged form (Br−) of the element bromine, a member of the halogens group on the periodic table. Most bromides are colorless. Bromides have many practical roles, being found in anticonvulsants, flame-retard ...

s :N05CM12 Apronal :N05CM13 Valnoctamide :N05CM15 Methylpentynol :N05CM16 Niaprazine :N05CM18 Dexmedetomidine :QN05CM90 Detomidine :QN05CM91 Medetomidine :QN05CM92

Xylazine Xylazine is a structural analog of clonidine and an α2-adrenergic receptor, α2-adrenergic receptor agonist, sold under many trade names worldwide, most notably the Bayer brand name Rompun, as well as Anased, Sedazine and Chanazine. Xylazine ...

:QN05CM93 Romifidine :QN05CM94 Metomidate :QN05CM96 Tasipimidine :QN05CM99 Combinations

N05CX Hypnotics and sedatives in combination, excluding barbiturates

:N05CX01

, combinations :N05CX02

, combinations :N05CX03 Methylpentynol, combinations :N05CX04 Clomethiazole, combinations :N05CX05 Emepronium, combinations :N05CX06 Dipiperonylaminoethanol, combinations

References

{{Hypnotics and sedatives N05

N05A Antipsychotic Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), p ...s