ASR-3001, also known as 5-methoxy-''N''-allyl-''N''-isopropyltryptamine (5-MeO-iPALT), is a

serotonin receptor agonist A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin (5-hydroxytryptamine; 5-HT), a neurotransmitter and hormone and the endogenous ligand of t ...

and

serotonergic psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

of the

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...

and

5-methoxytryptamine 5-Methoxytryptamine (5-MT, 5-MeO-T, or 5-OMe-T), also known as serotonin methyl ether or ''O''-methylserotonin and as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. It has been shown to oc ...

families which is under development for the treatment of

psychiatric disorder A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...

s. It is a close analogue of related psychedelic tryptamines like

5-MeO-DALT 5-MeO-DALT, also known as ''N'',''N''-diallyl-5-methoxytryptamine, or as foxtrot, is a psychedelic drug of the substituted tryptamine, tryptamine and substituted 5-methoxytryptamine, 5-methoxytryptamine families. It was first chemical synthesis, ...

5-MeO-DiPT 5-MeO-DiPT, also known as 5-methoxy-''N'',''N''-diisopropyltryptamine and sometimes as foxy methoxy or simply foxy, is a psychedelic drug of the tryptamine and 5-methoxytryptamine families. It is the 5-methoxy derivative of diisopropyltryptami ...

, and 5-MeO-MiPT. The drug acts as a non-selective

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

of the

serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in multiple tissues including the central and peripheral nervous systems. They mediate both ex ...

s. This includes of the

serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...

5-HT_2A, 5-HT_2B, 5-HT_1A, 5-HT_1B, and 5-HT₆ receptors, whereas other serotonin receptors, such as the serotonin 5-HT_2C receptor, were not described. Its values were 9.85nM at the serotonin 5-HT_2A receptor, 46.8nM at the serotonin 5-HT_1B receptor, 87.4nM at the serotonin 5-HT_2B receptor, 420nM at the serotonin 5-HT₆ receptor, and 642nM at the serotonin 5-HT_1A receptor. The drug was also a very weak

serotonin reuptake inhibitor A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the drug action, action of the serotonin transporter (SERT). This in turn lea ...

( = 6,840nM), but did not inhibit

norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic compound, organic chemical in the catecholamine family that functions in the brain and human body, body as a hormone, neurotransmitter and neuromodulator. The ...

dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...

reuptake Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmi ...

. It also showed little or no activity at various other sites. ASR-3001 is said to be orally active, fast- and short-acting, and to induce "an internal psychedelic cognitive state r head spacewith little or no sensory r visualinvolvement". More specifically, it is said to have an absence of open-eye and

closed-eye visual Closed-eye hallucinations and closed-eye visualizations (CEV) are hallucinations that occur when one's eyes are closed or when one is in a darkened room. They should not be confused with phosphenes, perceived light and shapes when pressure is ap ...

s. These properties are expected to allow ASR-3001 to serve as a potential "entry point" for people reluctant to undergo a fully immersive psychedelic experience that includes

visual The visual system is the physiological basis of visual perception (the ability to detect and process light). The system detects, transduces and interprets information concerning light within the visible range to construct an image and buil ...

s. ASR-3001 is said to be internally psychedelic as opposed to

entactogen Entactogens, also known as empathogens or connectogens, are a class of psychoactive drugs that induce the production of experiences of emotional communion, oneness, connectedness, emotional openness—that is, empathy—as particularly observe ...

ic. Its dose range is 8 to 14mg (or perhaps up to 10mg), its onset is within 15minutes or as fast as 6 to 8minutes, and its duration is short at about 1.5 to 2.5hours (90–150minutes). ASR-3001 is under development by the Nicholas V. Cozzi and Paul F. Daley and colleagues at the Alexander Shulgin Research Institute (ASRI). It was first described by 2023 and was

patent A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an sufficiency of disclosure, enabling discl ...

ed the same year. As of early 2025, ASR-3001 is in the

preclinical research In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and dr ...

stage of development. It is the ASRI's most advanced developmental candidate. Other related analogues of ASR-3001 include ASR-3002 (2-Me-iPALT), ASR-3003 (iPALT), and ASR-3004 (PALT), among others.

References

External links

5-MeO-ALIPT - Isomer Design

{{Tryptamines 5-HT1A agonists 5-HT1B agonists 5-HT2A agonists 5-HT2B agonists 5-HT6 agonists Allyl compounds N,N-Dialkyltryptamines Experimental hallucinogens Isopropyl compounds 5-Methoxytryptamines Psychedelic tryptamines Serotonin receptor agonists

See also

References

External links