ADB-PINACA is a

cannabinoid Cannabinoids () are several structural classes of compounds found primarily in the ''Cannabis'' plant or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoact ...

designer drug that is an ingredient in some synthetic cannabis products. It is a potent

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

of the CB₁ receptor and CB₂ receptor with EC₅₀ values of 0.52 nM and 0.88 nM respectively. Like MDMB-FUBINACA, this compound incorporates the unnatural amino acid ''tert''-leucine.

Side effects

ADB-PINACA has been linked to multiple hospitalizations and deaths due to its use.

Metabolism

Nineteen ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included pentyl hydroxylation, hydroxylation followed by oxidation (ketone formation), and glucuronidation.

Legality

ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015. In the United States, it is a

Schedule I controlled substance The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United State ...

. but its 5'-bromo analog ADB-5'Br-PINACA is not as of October 20th, 2023. As of October 2015 ADB-PINACA is a controlled substance in China.

References

{{reflist Cannabinoids Designer drugs Indazolecarboxamides Tert-butyl compounds

Side effects

Metabolism

Legality

See also

References