5-Methoxy-α-ethyltryptamine (5-MeO-αET) is a

psychoactive drug A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, psychoactive substance, or psychotropic substance is a chemical substance that alters psychological functioning by modulating central nervous system acti ...

and member of the

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...

family. It reportedly produces

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

and

stimulant Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, ...

effects.

Use and dosage

5-MeO-αET, when used recreationally, is usually taken orally at doses of 50 to 75mg.

Effects

5-MeO-αET produces entactogenic and stimulant effects that can last 4 to 6hours. However, little information exists on the psychopharmacological effects of this compound, thus considerable variation with regard to dosage and effects can be expected.

Dangers

There have been no reported deaths or hospitalizations from 5-MeO-αET, but its safety profile is unknown.

Pharmacology

The

pharmacology Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur betwee ...

of 5-MeO-αET has been studied. It is a weak

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given Receptor (biochemistry), receptor, but have only partial Intrinsic activity, efficacy at the receptor relative to a full agonist. They may also be considered Ligand (bio ...

of the

serotonin Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, ...

5-HT_2A receptor, with a

binding affinity In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from Latin ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usuall ...

(K_i) of 4,073nM, an of 166nM, and an of 34%. For comparison, αET showed 14-fold lower affinity for the receptor than 5-MeO-αET and was inactive as an agonist of the receptor. The individual

stereoisomer In stereochemistry, stereoisomerism, or spatial isomerism, is a form of isomerism in which molecules have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in ...

s of 5-MeO-αET and αET were also assessed.

Legal status

5-MeO-αET is unscheduled and uncontrolled in the United States, but possession and sales of 5-MeO-αET could be prosecuted under the

Federal Analog Act The Federal Analogue Act, , is a section of the United States Controlled Substances Act passed in 1986 which allows any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were listed ...

because of its structural similarities to αET and αMT.

References

External links

5-MeO-AET - Isomer Design

The Small & Handy 5-MeO-AET Thread - Bluelight
{{Tryptamines 5-HT2A agonists Alpha-Alkyltryptamines Designer drugs 5-Methoxytryptamines Psychedelic tryptamines Serotonin receptor agonists