In
enzymology, a 4-hydroxyproline epimerase () is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...
that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycl ...
the
chemical reaction
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and break ...
:''trans''-4-hydroxy-L-proline
''cis''-4-hydroxy-D-proline
Hence, this enzyme has one
substrate
Substrate may refer to:
Physical layers
*Substrate (biology), the natural environment in which an organism lives, or the surface or medium on which an organism grows or is attached
** Substrate (locomotion), the surface over which an organism lo ...
,
trans-4-hydroxy-L-proline, and one
product
Product may refer to:
Business
* Product (business), an item that serves as a solution to a specific consumer problem.
* Product (project management), a deliverable or set of deliverables that contribute to a business solution
Mathematics
* Prod ...
,
cis-4-hydroxy-D-proline.
This enzyme belongs to the family of
isomerase
Isomerases are a general class of enzymes that convert a molecule from one isomer to another. Isomerases facilitate intramolecular rearrangements in which bonds are broken and formed. The general form of such a reaction is as follows:
A–B � ...
s, specifically those
racemase Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules.
Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asym ...
s and
epimerase Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules.
Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymme ...
s acting on
amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ...
s and derivatives. The
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
of this enzyme class is 4-hydroxyproline 2-epimerase. Other names in common use include hydroxyproline epimerase, hydroxyproline 2-epimerase, and L-hydroxyproline epimerase. This enzyme participates in
arginine and proline metabolism Arginine and proline metabolism is one of the central pathways for the biosynthesis of the amino acids arginine and proline from glutamate. The pathways linking arginine, glutamate, and proline are bidirectional. Thus, the net utilization or produc ...
.
References
*
EC 5.1.1
Enzymes of unknown structure
{{isomerase-stub