4-Hydroxy-''N''-allyltryptamine (4-HO-NALT) is a
tryptamine
Tryptamine is an indolamine metabolite of the essential amino acid tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the firs ...
derivative developed by modification of
norpsilocin
Norpsilocin, also known as 4-hydroxy-''N''-methyltryptamine (4-HO-NMT), is a tryptamine alkaloid recently discovered in 2017 in the psychedelic mushroom ''Psilocybe cubensis''. It is hypothesized to be a dephosphorylated metabolite of baeocysti ...
(4-HO-NMT). It produces a
head-twitch response
The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats in association with serotonin 5-HT2A receptor activation. Serotonergic psychedelics like lys ...
in mice consistent with psychedelic-like activity, as do the corresponding ethyl, propyl, isopropyl and benzyl derivatives (4-HO-NET, 4-HO-NPT, 4-HO-NiPT and 4-HO-NBnT), but the bulkier t-butyl and cyclohexyl derivatives are inactive.
See also
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4-AcO-DALT
4-Acetyloxy-''N,N''-diallyltryptamine (or 4-AcO-DALT) is a tryptamine derivative (chemistry), derivative. It has been sold as a designer drug, but little other information is available. It was first officially identified in seized drug samples in ...
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4-HO-MALT
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5-HO-DiPT
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5-MeO-T-NBOMe
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NTBT
References
Allylamines
4-Hydroxytryptamines
N-Monoalkyltryptamines
Psychedelic tryptamines
Secondary amines
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