4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABA_B receptor

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

which was never marketed. It is selective for the GABA_B receptor over the GABA_A receptor ( IC₅₀ = 1.70 μM and > 100 μM, respectively). The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA),

tolibut Tolibut, also known as 3-(''p''-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and is the 4-methyl analogue of phenibu ...

(β-(4-methylphenyl)-GABA), and

phenibut Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic effects, and is used to treat anxiety, insomnia, and for a variety of other indications. It is usually taken ...

(β-phenyl-GABA). It is less potent as a GABA_B receptor agonist than baclofen but more potent than phenibut. The substance is sometimes referred to as 4F-phenibut or F-phenibut and colloquially as fluorobut.

Legal status

F-Phenibut is a prohibited substance in Lithuania and Hungary.MAGYARORSZÁG HIVATALOS LAPJA
Retrieved 2021-04-28.

References

Amines Carboxylic acids Experimental drugs Fluoroarenes GABA analogues GABAB receptor agonists {{Nervous-system-drug-stub