4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a
GABAB receptor agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
which was never marketed.
It is
selective for the GABA
B receptor over the
GABAA receptor (
IC50 = 1.70 μM and > 100 μM, respectively).
The drug is a
GABA analogue and is closely related to
baclofen (β-(4-chlorophenyl)-GABA),
tolibut (β-(4-methylphenyl)-GABA), and
phenibut
Phenibut, sold under the brand name Anvifen among others, is a central nervous system (CNS) depressant with anxiolytic effects, and is used to treat anxiety, insomnia, and for a variety of other indications. It is usually taken oral administrat ...
(β-phenyl-GABA).
It is less potent as a GABA
B receptor agonist than baclofen but more potent than phenibut.
The substance is sometimes referred to as 4F-phenibut, F-phenibut, or baflofen, and colloquially as fluorobut.
Legal status
F-Phenibut is a prohibited substance in Lithuania and Hungary.
MAGYARORSZÁG HIVATALOS LAPJA
Retrieved 2021-04-28.
References
Designer drugs
Experimental drugs
4-Fluorophenyl compounds
GABA analogues
GABAB receptor agonists
Gamma-Amino acids
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