3CLpro-1 is an

antiviral Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Antiviral drugs are a class of antimicrobials ...

drug related to

rupintrivir Rupintrivir (AG-7088, Rupinavir) is a peptidomimetic antiviral drug which acts as a 3C and 3CL protease inhibitor. It was developed for the treatment of rhinoviruses, and has subsequently been investigated for the treatment of other viral dise ...

which acts as a 3CL protease inhibitor and was originally developed for the treatment of human

enterovirus 71 Enterovirus 71 (EV71), also known as Enterovirus A71 (EV-A71), is a virus of the genus ''Enterovirus'' in the ''Picornaviridae'' family, notable for its role in causing epidemics of severe neurological disease and hand, foot, and mouth disease i ...

. It is one of the most potent of a large series of compounds developed as inhibitors of the viral enzyme

3CL protease The 3C-like protease (3CLpro) or main protease (Mpro), formally known as C30 endopeptidase or 3-chymotrypsin-like protease, is the main protease found in coronaviruses. It cleaves the coronavirus polyprotein at eleven conserved sites. It is a cy ...

, with an ''in vitro'' IC₅₀ of 200 nM. It also shows activity against

coronavirus Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the comm ...

diseases such as

SARS Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the virus SARS-CoV-1, the first identified strain of the SARS-related coronavirus. The first known cases occurred in November 2002, and the ...

and

MERS Middle East respiratory syndrome (MERS) is a viral respiratory infection caused by '' Middle East respiratory syndrome–related coronavirus'' (MERS-CoV). Symptoms may range from none, to mild, to severe depending on age and risk level. Typi ...

, and is under investigation as a potential treatment agent for the viral disease

COVID-19 Coronavirus disease 2019 (COVID-19) is a contagious disease caused by the coronavirus SARS-CoV-2. In January 2020, the disease spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 can vary but often include fever ...

References

Antiviral drugs SARS-CoV-2 main protease inhibitors {{antiinfective-drug-stub

See also

References