3-Aminopyridine is an
aminopyridine. It is a colorless solid.
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Preparation
3-Aminopyridine is prepared by heating nicotinamide
Nicotinamide (International nonproprietary name, INN, British Approved Name, BAN ) or niacinamide (United States Adopted Name, USAN ) is a form of vitamin B3, vitamin B3 found in food and used as a dietary supplement and medication. As a suppl ...
with sodium hypobromite ( Hofmann rearrangement), which is in turn prepared ''in situ'' by the reaction of sodium hydroxide
Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula . It is a white solid ionic compound consisting of sodium cations and hydroxide anions .
Sodium hydroxide is a highly corrosive base (chemistry), ...
and bromine
Bromine is a chemical element; it has chemical symbol, symbol Br and atomic number 35. It is a volatile red-brown liquid at room temperature that evaporates readily to form a similarly coloured vapour. Its properties are intermediate between th ...
at 70 °C.
:
It can be used in the synthesis of organic ligand 3-pyridylnicotinamide. Troxipide is another synthesis that uses 3-AP.
Toxicity
The acute toxicity is indicated by the LD50
In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. The value of LD50 for a substance is the dose requ ...
= 178 mg/kg (quail, oral).
References
{{DEFAULTSORT:Aminopyridine, 3-
3-Aminopyridines
3-Pyridyl compounds