2C-T-21.5, also known as 4-(2,2-difluoroethylthio)-2,5-dimethoxyphenethylamine, is a lesser-known

psychedelic drug Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluc ...

related to compounds such as

2C-T-21 2C-T-21, also known as 4-(2-fluoroethylthio)-2,5-dimethoxyphenethylamine, is a psychedelic phenethylamine of the 2C family sometimes used as an entheogen. It was first synthesized by Alexander Shulgin. Dosage In his book '' PiHKAL (Phenethyla ...

and

2C-T-28 2C-T-28, also known as 4-(3-fluoropropylthio)-2,5-dimethoxyphenethylamine, is a lesser-known psychedelic drug related to compounds such as 2C-T-7 and 2C-T-21. It was named by Alexander Shulgin but was never made or tested by him, and was instead ...

. It was originally named by

Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American biochemist, broad researcher of synthetic psychoactive compounds, and author of works regarding these, who independently explored the organic chemistry and ph ...

and discussed in his book

PiHKAL ''PiHKAL: A Chemical Love Story'' is a book by Alexander Shulgin and Ann Shulgin published in 1991. The subject of the work is Psychoactive drug, psychoactive phenethylamine Derivative (chemistry), chemical derivatives, notably those that act ...

, but was not synthesised at that time. 2C-T-21.5 was ultimately synthesised and tested by

Daniel Trachsel Daniel Trachsel is a Swiss people, Swiss chemist who studies psychedelic drug, psychedelics and entactogens. He has developed and published on a large number of novel psychedelic and entactogen chemical compound, compounds, including their psycho ...

some years later. It has a

binding affinity In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from Latin ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usuall ...

of 146 nM at 5-HT_2A and 55 nM at 5-HT_2C. It produces typical

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

effects, being slightly less potent but somewhat longer acting than

2C-T-2 2C-T-2, also known as 4-ethylthio-2,5-dimethoxyphenethylamine, is a psychedelic and entactogenic phenethylamine of the 2C family. It was first synthesized in 1981 by Alexander Shulgin, and rated by him as one of the "magical half-dozen" most ...

or 2C-T-21, with an active dose of 12–30 mg, and a duration of action of 8–14 hours. Unlike 2C-T-21 it will not form the highly toxic

fluoroacetate Fluoroacetate may refer to: * Salts of fluoroacetic acid such as sodium fluoroacetate * Fluoroacetate anion (), a conjugate base of fluoroacetic acid * Esters In chemistry, an ester is a chemical compound, compound derived from an acid (either ...

as a metabolite, instead producing the less toxic difluoroacetic acid.

References

2C (psychedelics) Entheogens Thioethers Amines Methoxy compounds Organofluorides {{psychoactive-stub

See also

References