1-ethynylcyclohexanol Synthesis on:
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1-Ethynylcyclohexanol (ECX) is an alkynyl
1-Ethynylcyclohexanol can be prepared from
alcohol
Alcohol most commonly refers to:
* Alcohol (chemistry), an organic compound in which a hydroxyl group is bound to a carbon atom
* Alcohol (drug), an intoxicant found in alcoholic drinks
Alcohol may also refer to:
Chemicals
* Ethanol, one of sev ...
derivative which is both a synthetic precursor to, and an active metabolite An active metabolite is an active form of a drug after it has been processed by the body.
Metabolites of drugs
An active metabolite results when a drug is metabolized by the body into a modified form which continues to produce effects in the body ...
of the tranquilizer ethinamate
Ethinamate (Valamin, Valmid) is a short-acting carbamate-derivative sedative-hypnotic medication used to treat insomnia. Regular use leads to drug tolerance, and it is usually not effective for more than 7 days. Prolonged use can lead to dep ...
, and has similar sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but t ...
, anticonvulsant
Anticonvulsants (also known as antiepileptic drugs or recently as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of b ...
and muscle relaxant effects. It has been sold as a designer drug, first being identified in the UK in March 2012.
Preparation
1-Ethynylcyclohexanol can be prepared from cyclohexanone
Cyclohexanone is the organic compound with the formula (CH2)5CO. The molecule consists of six-carbon cyclic molecule with a ketone functional group. This colorless oily liquid has an odor reminiscent of acetone. Over time, samples of cyclohexan ...
by the reacting it with sodium acetylide in liquid ammonia
Ammonia is an inorganic compound of nitrogen and hydrogen with the formula . A stable binary hydride, and the simplest pnictogen hydride, ammonia is a colourless gas with a distinct pungent smell. Biologically, it is a common nitrogenous was ...
, followed by an acidic work-up.
See also
*1,6-Dioxecane-2,7-dione
1,6-Dioxecane-2,7-dione is a chemical compound classified as a lactone. It is formed as an impurity in the manufacture of polymer resins and biodegradable polyesters. It is the cyclic dimer of GHB and has been sold as a designer drug.
See also
* ...
* 2-Methyl-2-butanol
''tert''-Amyl alcohol (TAA) or 2-methylbutan-2-ol (2M2B), is a branched pentanol.
Historically TAA has been used an anesthetic and more recently used as a recreational drug. TAA is mostly a positive allosteric modulator for GABAA receptors in ...
* 2-Methyl-2-pentanol
2-Methyl-2-pentanol (IUPAC name: 2-methylpentan-2-ol) is an organic chemical compound. It can be added to a gas chromatograph to help distinguish between branched compounds, especially alcohols. Its presence in urine can be used to test for expos ...
* 3-Methyl-3-pentanol
3-Methyl-3-pentanol (IUPAC name: 3-methylpentan-3-ol) is an organic chemical compound and a tertiary hexanol. It is used in the synthesis of the tranquilizer emylcamate,
and has similar sedative and anticonvulsant actions itself.
Synthesis ...
* Clocental
* Ethchlorvynol
Ethchlorvynol is a GABA-ergic sedative and hypnotic/soporific medication first developed by Pfizer in the 1950s. In the United States it was sold by Abbott Laboratories under the trade name Placidyl. Placidyl was available in 200 mg, 500& ...
* Methylpentynol
* Prenderol
References
Alcohols Muscle relaxants Ethynyl compounds {{musculoskeletal-drug-stub