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Trypanosomiasis, Bovine
Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic protozoan trypanosomes of the genus ''Trypanosoma''. In humans this includes African trypanosomiasis and Chagas disease. A number of other diseases occur in other animals. African trypanosomiasis, which is caused by either ''Trypanosoma brucei gambiense'' or ''Trypanosoma brucei rhodesiense'', threatens some 65 million people in sub-Saharan Africa, especially in rural areas and populations disrupted by war or poverty. The number of cases has been going down due to systematic eradication efforts: in 1998 almost 40,000 cases were reported but almost 300,000 cases were suspected to have occurred; in 2009, the number dropped below 10,000; and in 2018 it dropped below 1000. Chagas disease causes 21,000 deaths per year mainly in Latin America. Signs and symptoms The tsetse fly bite erupts into a red chancre sore and within a few weeks, the person can experience fever, swollen lymph ...
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Vertebrates
Vertebrates () comprise all animal taxa within the subphylum Vertebrata () ( chordates with backbones), including all mammals, birds, reptiles, amphibians, and fish. Vertebrates represent the overwhelming majority of the phylum Chordata, with currently about 69,963 species described. Vertebrates comprise such groups as the following: * jawless fish, which include hagfish and lampreys * jawed vertebrates, which include: ** cartilaginous fish (sharks, rays, and ratfish) ** bony vertebrates, which include: *** ray-fins (the majority of living bony fish) *** lobe-fins, which include: **** coelacanths and lungfish **** tetrapods (limbed vertebrates) Extant vertebrates range in size from the frog species '' Paedophryne amauensis'', at as little as , to the blue whale, at up to . Vertebrates make up less than five percent of all described animal species; the rest are invertebrates, which lack vertebral columns. The vertebrates traditionally include the hagfish, wh ...
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Melarsoprol
Melarsoprol is an arsenic-containing medication used for the treatment of sleeping sickness (African trypanosomiasis). It is specifically used for second-stage disease caused by '' Trypanosoma brucei rhodesiense'' when the central nervous system is involved. For ''Trypanosoma brucei gambiense'', eflornithine or fexinidazole is usually preferred. It is effective in about 95% of people. It is given by injection into a vein. Melarsoprol has a high number of side effects. Common side effects include brain dysfunction, numbness, rashes, and kidney and liver problems. About 1-5% of people die during treatment, although this is tolerated due to sleeping sickness itself having a practically 100% mortality rate when untreated. In those with glucose-6-phosphate dehydrogenase (G6PD) deficiency, red blood cell breakdown may occur. It has not been studied in pregnancy. It works by blocking pyruvate kinase, an enzyme required for aerobic metabolism by the parasite. Melarsoprol has been us ...
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Surra
Surra (from the Marathi ''sūra'', meaning the sound of heavy breathing through nostrils, of imitative origin) is a disease of vertebrate animals. The disease is caused by protozoan trypanosomes, specifically '' Trypanosoma evansi'', of several species which infect the blood of the vertebrate host, causing fever, weakness, and lethargy which lead to weight loss and anemia. In some animals the disease is fatal unless treated. Overview An acute form of the disease, which is generally fatal unless treated, occurs in horses, donkeys, mules, cattle, buffalo, deer, camels, Article Number 21. p.2 llamas, dogs, and cats. This form is caused by ''Trypanosoma evansi'' (Steel 1885) (Balbiani 1888), and is transmitted by horse-flies, and also by the vampire bat, ''Desmodus rotundus'', in South-America. This form occurs in South America, Northern Africa, and the Middle East. This was the first form of pathogenic trypanosome discovered and was first described by Griffith Evans in 1880 ...
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Sudan
Sudan ( or ; ar, السودان, as-Sūdān, officially the Republic of the Sudan ( ar, جمهورية السودان, link=no, Jumhūriyyat as-Sūdān), is a country in Northeast Africa. It shares borders with the Central African Republic to the southwest, Chad to the west, Egypt to the north, Eritrea to the northeast, Ethiopia to the southeast, Libya to the northwest, South Sudan to the south and the Red Sea. It has a population of 45.70 million people as of 2022 and occupies 1,886,068 square kilometres (728,215 square miles), making it Africa's List of African countries by area, third-largest country by area, and the third-largest by area in the Arab League. It was the largest country by area in Africa and the Arab League until the 2011 South Sudanese independence referendum, secession of South Sudan in 2011, since which both titles have been held by Algeria. Its Capital city, capital is Khartoum and its most populated city is Omdurman (part of the metropolitan area of Khar ...
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Nagana
Animal trypanosomiasis, also known as nagana and nagana pest, or sleeping sickness, is a disease of vertebrates. The disease is caused by trypanosomes of several species in the genus ''Trypanosoma'' such as ''Trypanosoma brucei''. '' Trypanosoma vivax'' causes nagana mainly in West Africa, although it has spread to South America. The trypanosomes infect the blood of the vertebrate host, causing fever, weakness, and lethargy, which lead to weight loss and anemia; in some animals the disease is fatal unless treated. The trypanosomes are transmitted by tsetse flies. An interesting feature is the remarkable tolerance to nagana pathology shown by some breeds of cattle, notably the N'Dama – a West African '' Bos taurus'' breed. This contrasts with the susceptibility shown by East African ''Bos indicus'' cattle such as the zebu. Transmission Most trypanosomes develop in tsetse flies (''Glossina'' spp.), its biological vector, in about one to a few weeks. When an infected tsetse fly ...
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IAEA
The International Atomic Energy Agency (IAEA) is an intergovernmental organization that seeks to promote the peaceful use of nuclear energy and to inhibit its use for any military purpose, including nuclear weapons. It was established in 1957 as an autonomous organization within the United Nations system; though governed by its own founding treaty, the organization reports to both the General Assembly and the Security Council of the United Nations, and is headquartered at the UN Office at Vienna, Austria. The IAEA was created in response to growing international concern toward nuclear weapons, especially amid rising tensions between the foremost nuclear powers, the United States and the Soviet Union. U.S. President Dwight D. Eisenhower's " Atoms for Peace" speech, which called for the creation of an international organization to monitor the global proliferation of nuclear resources and technology, is credited with catalyzing the formation of the IAEA, whose treaty came int ...
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Expo 2015
Expo 2015 was a World's fair, World Expo hosted by Milan, Italy. It opened on May 1 at 10:00 Central European Summer Time, CEST and closed on October 31. Milan hosted an exposition for the second time; the first was the 1906 Milan International (1906), Milan International. The Bureau International des Expositions (BIE) general assembly in Paris decided in favour of Milan on March 31, 2008. On November 23, 2010, the event was announced by the BIE. Expo 2015's theme was "Feeding the Planet, Energy for Life". Themes Expo 2015's theme was "Feeding the Planet, Energy for Life", encompassing technology, innovation, culture, traditions and creativity and how they relate to food and diet. The exposition developed themes introduced in earlier expos (such as water at Expo 2008 in Zaragoza) in light of new global scenarios and emerging issues, focusing on the right to food, right to healthy, secure and sufficient food for the world's inhabitants. Futuristic concerns about food security ...
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Trypanotolerant
A trypanotolerant organism is one which is relatively less affected by trypanosome infestation. By host In humans In livestock Some breeds are known for their trypanotolerance. This is especially important in Africa where a few particular trypanosomes are major economic and agricultural pests. Trypanotolerant livestock breeds * N'Dama cattle * West African Dwarf goats * West African Dwarf sheep The West African Dwarf or Djallonké is an African breed or group of breeds of domestic sheep. It is the dominant breed of West and Central Africa. This breed is primarily raised for meat. The Cameroon or Cameroon Dwarf is a breed within this gr ... (Djallonké) * Cameroon sheep History of genetic research Trypanotolerance had previously been achieved through normal livestock breeding in cattle, but genetic analysis was becoming a serious option in the 1980s. The effort that would eventually bear fruit began with a conversation between Peter Brumby - then at the International L ...
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Cattle Breed
List of cattle breeds — Over 1000 breeds of cattle are recognized worldwide, some of which adapted to the local climate, others which were bred by humans for specialized uses. Cattle breeds fall into two main types, which are regarded as either two closely related species, or two subspecies of one species. ''Bos indicus'' (or ''Bos taurus indicus'') cattle, commonly called zebu, are adapted to hot climates and originated in the tropical parts of the world such as India, Sub-saharan Africa, China, and Southeast Asia. ''Bos taurus'' (or ''Bos taurus taurus''), typically referred to as "taurine" cattle, are generally adapted to cooler climates and include almost all cattle breeds originating from Europe and northern Asia. In some parts of the world further species of cattle are found (both as wild and domesticated animals), and some of these are related so closely to taurine and indicus cattle that interspecies hybrids have been bred. Examples include the Dwarf Lulu cattle o ...
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The Washington Post
''The Washington Post'' (also known as the ''Post'' and, informally, ''WaPo'') is an American daily newspaper published in Washington, D.C. It is the most widely circulated newspaper within the Washington metropolitan area and has a large national audience. Daily broadsheet editions are printed for D.C., Maryland, and Virginia. The ''Post'' was founded in 1877. In its early years, it went through several owners and struggled both financially and editorially. Financier Eugene Meyer purchased it out of bankruptcy in 1933 and revived its health and reputation, work continued by his successors Katharine and Phil Graham (Meyer's daughter and son-in-law), who bought out several rival publications. The ''Post'' 1971 printing of the Pentagon Papers helped spur opposition to the Vietnam War. Subsequently, in the best-known episode in the newspaper's history, reporters Bob Woodward and Carl Bernstein led the American press's investigation into what became known as the Waterga ...
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Gamma Ray
A gamma ray, also known as gamma radiation (symbol γ or \gamma), is a penetrating form of electromagnetic radiation arising from the radioactive decay of atomic nucleus, atomic nuclei. It consists of the shortest wavelength electromagnetic waves, typically shorter than those of X-rays. With frequency, frequencies above 30 exahertz (), it imparts the highest photon energy. Paul Ulrich Villard, Paul Villard, a French chemist and physicist, discovered gamma radiation in 1900 while studying radiation emitted by radium. In 1903, Ernest Rutherford named this radiation ''gamma rays'' based on their relatively strong penetration of matter; in 1900 he had already named two less penetrating types of decay radiation (discovered by Henri Becquerel) alpha particle, alpha rays and beta particle, beta rays in ascending order of penetrating power. Gamma rays from radioactive decay are in the energy range from a few kiloelectronvolts (keV) to approximately 8 megaelectronvolts (MeV), corres ...
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