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Trigeminal Nucleus
The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla, and into the upper cervical spinal cord. The nucleus is divided into three parts, from rostral to caudal (top to bottom in humans): * The mesencephalic nucleus * The principal sensory nucleus * The spinal trigeminal nucleus ::The spinal trigeminal nucleus is further subdivided into three parts, from rostral to caudal: :* Pars oralis (from the Pons to the Hypoglossal nucleus) :* Pars interpolaris (from the Hypoglossal nucleus to the obex) :* Pars caudalis (from the obex to C2) There is also a distinct trigeminal motor nucleus that is medial to the principal sensory nucleus. See also * Photic sneeze reflex * Trigeminal nerve In neuroanatomy, the trigeminal nerve (literal translation, lit. ''triplet'' nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for Sense, s ...
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Sensory System
The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons (including the sensory receptor cells), neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation. Sense organs are transducers that convert data from the outer physical world to the realm of the mind where people interpret the information, creating their perception of the world around them. The receptive field is the area of the body or environment to which a receptor organ and receptor cells respond. For instance, the part of the world an eye can see, is its receptive field; the light that each rod or cone can see, is its receptive field. Receptive fields have been identified for the visual system, auditory system and somatosensory system. Senses and receptors Whi ...
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Cranial Nerve Nucleus
A cranial nerve nucleus is a collection of neuron cell bodies (gray matter) in the brain stem that is associated with one or more of the cranial nerves. Axons carrying information to and from the cranial nerves form a synapse first at these nucleus (neuroanatomy), nuclei. Lesions occurring at these nuclei can lead to effects resembling those seen by the severing of nerve(s) they are associated with. All the nuclei except that of the trochlear nerve (CN IV) supply nerves of the same side of the body. Structure Motor and sensory In general, motor nuclei are closer to the front (ventral), and sensory nuclei and neurons are closer to the back (dorsum (anatomy), dorsal). This arrangement mirrors the arrangement of tracts in the spinal cord. * Close to the midline are the motor efferent nuclei, such as the oculomotor nucleus, which control skeletal muscle. Just lateral to this are the autonomic (or visceral) efferent nuclei. * There is a separation, called the sulcus limitans, and later ...
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Midbrain
The midbrain or mesencephalon is the uppermost portion of the brainstem connecting the diencephalon and cerebrum with the pons. It consists of the cerebral peduncles, tegmentum, and tectum. It is functionally associated with vision, hearing, motor control, sleep and wakefulness, arousal (alertness), and temperature regulation.Breedlove, Watson, & Rosenzweig. Biological Psychology, 6th Edition, 2010, pp. 45-46 The name ''mesencephalon'' comes from the Greek ''mesos'', "middle", and ''enkephalos'', "brain". Structure The midbrain is the shortest segment of the brainstem, measuring less than 2cm in length. It is situated mostly in the posterior cranial fossa, with its superior part extending above the tentorial notch. The principal regions of the midbrain are the tectum, the cerebral aqueduct, tegmentum, and the cerebral peduncles. Rostral and caudal, Rostrally the midbrain adjoins the diencephalon (thalamus, hypothalamus, etc.), while Rostral and caudal, cau ...
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Pons
The pons (from Latin , "bridge") is part of the brainstem that in humans and other mammals, lies inferior to the midbrain, superior to the medulla oblongata and anterior to the cerebellum. The pons is also called the pons Varolii ("bridge of Varolius"), after the Italian anatomist and surgeon Costanzo Varolio (1543–75). This region of the brainstem includes neural pathways and tracts that conduct signals from the brain down to the cerebellum and medulla, and tracts that carry the sensory signals up into the thalamus. Structure The pons in humans measures about in length. It is the part of the brainstem situated between the midbrain and the medulla oblongata. The horizontal ''medullopontine sulcus'' demarcates the boundary between the pons and medulla oblongata on the ventral aspect of the brainstem, and the roots of cranial nerves VI/VII/VIII emerge from the brainstem along this groove. The junction of pons, medulla oblongata, and cerebellum forms the cerebellopontine ...
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Medulla Oblongata
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem. It is anterior and partially inferior to the cerebellum. It is a cone-shaped neuronal mass responsible for autonomic (involuntary) functions, ranging from vomiting to sneezing. The medulla contains the cardiovascular center, the respiratory center, vomiting and vasomotor centers, responsible for the autonomic functions of breathing, heart rate and blood pressure as well as the sleep–wake cycle. "Medulla" is from Latin, ‘pith or marrow’. And "oblongata" is from Latin, ‘lengthened or longish or elongated'. During embryonic development, the medulla oblongata develops from the myelencephalon. The myelencephalon is a secondary brain vesicle which forms during the maturation of the rhombencephalon, also referred to as the hindbrain. The bulb is an archaic term for the medulla oblongata. In modern clinical usage, the word bulbar (as in bulbar palsy) is r ...
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Mesencephalic Nucleus
The mesencephalic nucleus of trigeminal nerve is one of the sensory nuclei of the trigeminal nerve (cranial nerve V). It is located in the brainstem. It receives proprioceptive sensory information from the muscles of mastication and other muscles of the head and neck. It is involved in processing information about the position of the jaw/teeth. It is functionally responsible for preventing excessive biting that may damage the dentition, regulating tooth pain perception, and mediating the jaw jerk reflex (by means of projecting to the motor nucleus of the trigeminal nerve). The axons of the neuron cell bodies of this nucleus provide sensory innervation to target tissues directly, whereas other sensory nuclei of the trigeminal nerve receive their sensory inputs by synapsing with primary sensory neurons in the trigeminal ganglion. Anatomy The MNTN is located in the brainstem, more specifically (sources vary) spanning the length of the midbrain/in the caudal midbrain and rostral p ...
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Principal Sensory Nucleus
The principal sensory nucleus of trigeminal nerve (or chief sensory nucleus of V, main trigeminal sensory nucleus) is a group of second-order neurons which have cell bodies in the caudal pons. It receives information about discriminative sensation and light touch of the face as well as conscious proprioception of the jaw via first order neurons of CN V. * Most of the sensory information crosses the midline and travels to the contralateral ventral posteromedial nucleus (VPM) of the thalamus via the anterior trigeminothalamic tract The ventral trigeminal tract, ventral trigeminothalamic tract, anterior trigeminal tract, or anterior trigeminothalamic tract, is a nerve tract, tract composed of second-order neuron, second-order neuronal axons. These afferent fibers carry sensor .... * However, information of the ''oral cavity'' travels to the ipsilateral VPM of the thalamus via the dorsal trigeminothalamic tract. {{Authority control Cranial nerve nuclei Trigeminal nerve Pons ...
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Spinal Trigeminal Nucleus
The spinal trigeminal nucleus is a nucleus in the medulla that receives information about deep/crude touch, pain, and temperature from the ipsilateral face. In addition to the trigeminal nerve (CN V), the facial (CN VII), glossopharyngeal (CN IX), and vagus nerves (CN X) also convey pain information from their areas to the spinal trigeminal nucleus.Brainstem Nuclei
Thus the spinal trigeminal nucleus receives afferents from V, VII,
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Obex
The obex () is the point in the human brain at which the fourth ventricle narrows to become the central canal of the spinal cord. Cerebrospinal fluid can flow from the fourth ventricle into the obex. In anatomical studies, the obex has been found to occur approximately 10–12 mm above the level of the foramen magnum. In patients with low tonsillar position, the obex has been found at or below the plane of the foramen magnum. The obex occurs in the caudal medulla. The decussation of sensory fibers happens at this point. Clinical significance Lesions at the location can result in obstructive hydrocephalus. The most common lesion at this location is a subependymoma, a benign tumor. Hemangioblastoma has been observed in this location. Detection of prions Immunohistochemistry (IHC) to test brain, lymph, and neuroendocrine tissues for the presence of the abnormal prion protein to diagnose wasting diseases like chronic wasting disease in deer A deer (: deer) or ...
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Trigeminal Motor Nucleus
The trigeminal motor nucleus contains motor neurons that innervate muscles of the first branchial arch, namely the muscles of mastication, the tensor tympani, tensor veli palatini, mylohyoid, and anterior belly of the digastric.Brainstem Nuclei of the Cranial Nerves at wustl.edu
It is situated in the upper , inferior to the lateral part of the floor of the .


Lesion

The trigeminal motor nucleus forms the efferent pathway of the

Photic Sneeze Reflex
The photic sneeze reflex (also known as ACHOO syndrome, a contrived acronym for Autosomal-dominant Compelling Helio-Ophthalmic Outburst) is an inherited and congenital autosomal dominant reflex condition that causes sneezing in response to numerous stimuli, such as looking at bright lights or periocular (surrounding the eyeball) injection. The condition affects 18 to 35% of the world's population, but its exact mechanism of action is not well understood. Symptoms and signs The photic sneeze reflex manifests itself in the form of uncontrollable sneezing in response to a stimulus which would not produce a sneeze in people without the trait. The sneezes generally occur in bursts of 1 to 10 sneezes, followed by a refractory period that can be as long as 24 hours. Photic sneezing A photic sneeze results from exposure to a bright light and is the most common manifestation of the photic sneeze reflex. This reflex seems to be caused by a change in light intensity rather than by a speci ...
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Trigeminal Nerve
In neuroanatomy, the trigeminal nerve (literal translation, lit. ''triplet'' nerve), also known as the fifth cranial nerve, cranial nerve V, or simply CN V, is a cranial nerve responsible for Sense, sensation in the face and motor functions such as biting and chewing; it is the most complex of the cranial nerves. Its name (''trigeminal'', ) derives from each of the two nerves (one on each side of the pons) having three major branches: the ophthalmic nerve (V), the maxillary nerve (V), and the mandibular nerve (V). The ophthalmic and maxillary nerves are purely sensory, whereas the mandibular nerve supplies motor as well as sensory (or "cutaneous") functions. Adding to the complexity of this nerve is that Autonomic nervous system, autonomic nerve fibers as well as special sensory fibers (taste) are contained within it. The motor division of the trigeminal nerve derives from the Basal plate (neural tube), basal plate of the embryonic pons, and the sensory division originates in ...
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