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Tinofedrine
Tinofedrine (; developmental code name D-8955, proposed brand name Novocebrin), also known as ''N''-(3,3-di-3-thienyl)-2-propenyl)norephedrine, is a sympathomimetic and cerebral vasodilator of the amphetamine family which was never marketed. It is a derivative of norephedrine and an analogue of related agents like oxyfedrine, buphenine (nylidrin), and isoxsuprine Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator in humans (under the trade name Duvadilan) and equines. Isoxsuprine is a β2 adrenoreceptor agonist that causes direct relaxation of uterine and vascular smooth musc .... The drug was first described in the literature by 1978. References Abandoned drugs Beta-Hydroxyamphetamines Enantiopure drugs Sympathomimetics Thiophenes Vasodilators {{Pharma-stub Cerebral vasodilators ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Vasodilator
A cerebral vasodilator is a drug which acts as a vasodilator in the brain. They are used to improve blood flow in people with cerebrovascular insufficiency and to treat neurological disorders secondary to this condition. A number of different cerebral vasodilators exist. An example is ifenprodil, which has been marketed for use as a cerebral vasodilator in France, Hong Kong, and Japan. Other examples include buphenine (nylidrin), isoxsuprine, oxyfedrine, suloctidil, and tinofedrine. Similar drugs include cerebral activators, or cerebral metabolism activators, like bifemelane, indeloxazine, and teniloxazine, which are also used to treat cerebrovascular disease. See also * Nootropic References {{Reflist Drugs acting on the cardiovascular system Drugs acting on the nervous system Neuroprotective agents Vasodilators Cerebral vasodilators ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiophenes
Thiophene is a heterocyclic compound with the formula C4H4S. Consisting of a planar five-membered ring, it is aromaticity, aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene-like odor. In most of its reactions, it resembles benzene. Compounds analogous to thiophene include furan (C4H4O), selenophene (C4H4Se) and pyrrole (C4H4NH), which each vary by the heteroatom in the ring. Isolation and occurrence Thiophene was discovered by Viktor Meyer in 1882 as a contaminant in benzene. It was observed that isatin (an indole) forms a blue dye if it is mixed with sulfuric acid and crude benzene. The formation of the blue indophenin had long been believed to be a reaction of benzene itself. Viktor Meyer was able to isolate thiophene as the actual substance responsible for this reaction. Thiophene and especially its derivatives occur in petroleum, sometimes in concentrations up to 1–3%. The thiophenic content of Petroleum, oil and coal i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantiopure Drugs
An enantiopure drug is a pharmaceutical available in one specific enantiomeric form. Most biomolecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. The use of a drug with a single enantiomer intends to make it more effective. One enantiomer of a drug may have a desired beneficial effect while the other may cause serious and undesired side effects, or sometimes even beneficial but entirely different effects. The desired enantiomer is known as an ''eutomer'' while the undesired enantiomer is known as the ''distomer''. When equal amounts of both enantiomers are found in a mixture, the mixture is known as a racemic mixture. If a mixture for a drug does not have a 1:1 ratio of its enantiomers it is a candidate for an enantiopure drug. Advances in industrial chemical processes have made it economical for pharmaceutical manufacturers to take drugs that wer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abandoned Drugs
Abandon, abandoned, or abandonment may refer to: Common uses * Abandonment (emotional), a subjective emotional state in which people feel undesired, left behind, insecure, or discarded * Abandonment (legal), a legal term regarding property ** Child abandonment, the extralegal abandonment of children ** Lost, mislaid, and abandoned property, legal status of property after abandonment and rediscovery * Abandonment (mysticism) Art, entertainment, and media Film * ''Abandon'' (film), a 2002 film starring Katie Holmes * ''Abandoned'' (1949 film), starring Dennis O'Keefe * ''Abandoned'' (1955 film), the English language title of the Italian war film ''Gli Sbandati'' * ''Abandoned'' (2001 film), a Hungarian film * ''Abandoned'' (2010 film), starring Brittany Murphy * ''Abandoned'' (2015 film), a television movie about the shipwreck of the ''Rose-Noëlle'' in 1989 * ''Abandoned'' (2022 film), starring Emma Roberts * ''The Abandoned'' (1945 film), a 1945 Mexican film * ''The Aba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoxsuprine
Isoxsuprine (used as isoxsuprine hydrochloride) is a drug used as a vasodilator in humans (under the trade name Duvadilan) and equines. Isoxsuprine is a β2 adrenoreceptor agonist that causes direct relaxation of uterine and vascular smooth muscle via β2 receptors. Use In humans Isoxsuprine is used in humans for treatment of premature labor, i.e. a tocolytic, and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions. Isoxsuprine may increase the heart rate, cause changes in blood pressure, and irritate the GI tract. It should therefore be used with caution if combined with other drugs that affect blood pressure, such as sedatives and anesthetic drugs. In horses Isoxsuprine is most commonly used to treat hoof-related problems in the horse, most commonly for laminitis Laminitis is a disease of the feet of ungulates, found mostly in horses and cattle involving inflammation of the laminae. Clinical signs include fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxyfedrine
Oxyfedrine, sold under the brand names Ildamen and Myofedrin among others, is a sympathomimetic agent and coronary vasodilator which is used in the treatment of coronary heart disease, angina pectoris, and acute myocardial infarction. It is taken by mouth or intravenously. The drug acts as a β-adrenergic receptor partial agonist. It may also act as a norepinephrine releasing agent via its major active metabolite norephedrine. Oxyfedrine is a phenethylamine and amphetamine derivative. Oxyfedrine has been marketed in Europe, Hong Kong, India, Central America, and elsewhere. It appears to remain marketed only in India. Pharmacology Pharmacodynamics Oxyfedrine is a β-adrenergic receptor partial agonist. It appears to be non-selective for the β1- and β2-adrenergic receptors. It is selective for the β-adrenergic receptors over the α-adrenergic receptors. However, it has also been reported to interact with the α-adrenergic receptors at high concentrations, acting as a par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buphenine
Buphenine, also known as nylidrin and sold under the brand name Arlidin, is a β2 adrenoreceptor agonist that acts as a vasodilator Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. Blood vessel wal .... It was developed as a chemical derivative of oxilofrine, and first reported in the literature in 1950. See also * Isoxsuprine References Beta-Hydroxyamphetamines Beta2-adrenergic agonists NMDA receptor antagonists 4-Hydroxyphenyl compounds Tocolytics {{genito-urinary-drug-stub Cerebral vasodilators ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analog
A structural analog, also known as a chemical analog or simply an analog, is a chemical compound, compound having a chemical structure, structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronicity, isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analog (chemistry), functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is virtual screening, screened for structural analogs of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
