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Tetratricopeptide Motif
The tetratricopeptide repeat (TPR) is a structural motif. It consists of a degenerate 34 amino acid tandem repeat identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs, which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These alpha-helix pair repeats usually fold together to produce a single, linear solenoid domain called a TPR domain. Proteins with such domains include the anaphase-promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67-phox, hsp90-binding immunophilins, transcription factors, the protein kinase R (PKR), the major receptor for peroxisomal matrix protein import PEX5, protein arginine methyltransferase 9 (PRMT9), and mitochondrial import proteins. Structure The structure of the PP5 protein was the first structure to be determined. The structure solved by X-ray crystallography by Das and colleagues showed that the TPR sequence mot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Motif
In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a common three-dimensional structure that appears in a variety of different, evolutionarily unrelated molecules. A structural motif does not have to be associated with a sequence motif; it can be represented by different and completely unrelated sequences in different proteins or RNA. In nucleic acids Depending upon the sequence and other conditions, nucleic acids can form a variety of structural motifs which is thought to have biological significance. ;Stem-loop: Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded DNA or, more commonly, in RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions, base-pair to form a double helix that ends in an unpaired loop. The resulting structure is a key building block of many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TPR Repeats
TPR may refer to: Businesses and organisations *The Pensions Regulator, UK *The Princeton Review, a US educational company * Tapestry, Inc., an American clothing company (NYSE stock ticker: TPR) *Texas Public Radio Journals *'' Town Planning Review'', Liverpool University Press Science and technology Medicine *Tetratricopeptide repeat, a degenerate protein sequence *Total peripheral resistance, vascular resistance * Translocated promoter region, part of a protein Other uses in science and technology *True positive rate, a statistical measure *Thermoplastic elastomer, also called thermoplastic rubber Recreation * Tarbes Pyrénées Rugby, a French rugby club * Tournament performance rating, in chess Other uses * Thermoplastic rubber * Total physical response, a language teaching method * Tom Price Airport, IATA airport code *Trooper (rank) (Tpr), a military and police rank *Tuvan People's Republic The Tuvan People's Republic (TPR), known simply as Tannu Tuva, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNAJC7
DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the ''DNAJC7'' gene. Interactions DNAJC7 has been shown to interact with RAD9A Cell cycle checkpoint control protein RAD9A is a protein that in humans is encoded by the ''RAD9A'' gene.''Rad9'' has been shown to induce G2 arrest in the cell cycle in response to DNA damage in yeast cells. ''Rad9'' was originally found in budd .... References Further reading * * * * * * * * * * Heat shock proteins {{gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNAJC3
DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the ''DNAJC3'' gene. Function The protein encoded by this gene contains multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). Clinical significance An important role for DNAJC3 has been attributed to diabetes mellitus as well as multi system neurodegeneration. Diabetes mellitus and neurodegeneration are common diseases for which shared genetic factors are still only partly known. It was shown that loss of the BiP (immunoglobulin heavy-chain binding protein) co-chaperone DNAJC3 leads to diabetes mellitus and widespread neurodegeneration. Accordingly, three siblings were investigated with juvenile-onset diabetes and central and peripheral neurodegeneration, including ataxia, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CTR9
RNA polymerase-associated protein CTR9 homolog is an enzyme that in humans is encoded by the ''CTR9'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... References External links * Further reading * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNOT10
CCR4-NOT transcription complex subunit 10 is a protein that in humans is encoded by the CNOT10 gene. It is a subunit of the CCR4-Not Carbon Catabolite Repression 4—Negative On TATA-less, or CCR4-Not, is a multiprotein complex that functions in gene expression. The complex has multiple enzymatic activities as both a poly(A) 3′-5′ exonuclease and a ubiquitin ligase. T ... deadenylase complex. References Further reading * {{gene-3-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CABIN1
Calcineurin-binding protein cabin-1 is a protein that in humans is encoded by the ''CABIN1'' gene. Function Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. At least four alternatively spliced transcripts have been found for this gene, but the full-length nature of most of them has not been determined. Interactions CABIN1 has been shown to Protein-protein interaction, interact with: * Amphiphysin, * MEF2B, * MEF2D, and * SIN3A. References Further reading * * * * * * * * * * * * * * External links * * {{gene-22-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBS4
Bardet–Biedl syndrome 4 is a protein that in humans is encoded by the ''BBS4'' gene. This gene encodes a protein which contains tetratricopeptide repeats (TPR), similar to O-linked N-acetylglucosamine transferase. Mutations in this gene have been observed in patients with Bardet–Biedl syndrome type 4. The encoded protein may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation Intellectual disability (ID), also known as general learning disability (in the United Kingdom), and formerly mental retardation (in the United States), Rosa's Law, Pub. L. 111-256124 Stat. 2643(2010).Archive is a generalized neurodevelopmental .... Interactions BBS4 has been shown to interact with DCTN1. References Further reading * * * * * * * * External links GeneReviews/NIH/NCBI/UW entry on Bardet-Biedl Syndrome * {{gene-15-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ANAPC7
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ''ANAPC7'' gene. Multiple transcript variants encoding different isoforms have been found for this gene. Function This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell (biology), cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA (DNA re ... progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Interactions ANAPC7 has been shown to interact with ANAP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AAG2
AAG may refer to: * Ambrak language, a Torricelli language of Papua New Guinea * Assistant adjutant general, a military title * United States Assistant Attorney General, a ranking within the Department of Justice Aviation * Advanced Arresting Gear, an aircraft arresting system * Air Atlantique, ICAO airline designator * American Airlines Group * IATA airport code for Avelino Vieira Airport in Arapoti, State of Paraná, Brazil Business * American Advisors Group Film and television * ''Aag'' (1948 film), a 1948 Bollywood film * ''Aag'' (1994 film), a 1994 Bollywood film * ''Aag'' (2007 film), a 2007 Bollywood film * AAG TV, a Pakistani TV channel Medicine * Acute angle closure glaucoma * alpha-1-acid glycoprotein, also referred to as Orosomucoid (ORM) * alkyladenine glycosylase; see Deamination * Autoimmune autonomic ganglionopathy * AAG, a codon for the amino acid lysine Organizations * American Association of Geographers * Association of Applied Geochemists * Athl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neutrophil Cytosolic Factor 2
Neutrophil cytosol factor 2 is a protein that in humans is encoded by the ''NCF2'' gene. Function This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the react .... References Further reading * * * * * * * * * * * * * * * * * External links * {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hop (protein)
Stress-induced-phosphoprotein 1 also Hsp70-Hsp90 organising protein (Hop) is encoded in the human by the ''STIP1'' gene. It functions as a co-chaperone which reversibly links together the protein chaperones Hsp70 and Hsp90. STI1 belongs to the large group of co-chaperones, which regulate and assist the major chaperones (mainly heat shock proteins). It is one of the best studied co-chaperones of the Hsp70-Hsp90 complex. It was first discovered in yeast and homologues were identified in humans, mice, rats, insects, plants, parasites, and viruses. The family of these proteins is referred to as STI1 (stress inducible protein) and can be divided into yeast, plant, and animal STI1 (Hop). Synonyms Gene ''STIP1'' is located on chromosome 11q13.1 and consists of 14 exons. Structure STI proteins are characterized by some structural features: All homologues have nine tetratricopeptide repeat (TPR) motifs, that are clustered into domains of three TPRs. The TPR motif is a very ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
