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Synthetic Ribosome
Synthetic ribosomes are artificial small-molecules that can synthesize peptides in a sequence-specific matter. David Alan Leigh's lab built synthetic ribosome using a chemical structure based on a rotaxane In chemistry, a rotaxane () is a mechanically interlocked molecular architecture consisting of a dumbbell-shaped molecule which is threaded through a macrocycle (see graphical representation). The two components of a rotaxane are kinetically .... The Cédric Orelle research group created ribosomes with tethered and inseparable subunits (or Ribo-T). References {{Reflist Synthetic biology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Leigh (scientist)
David Alan Leigh (born 1963) FRS FRSE FRSC is a British chemist, Royal Society Research Professor and, since 2014, the Sir Samuel Hall Chair of Chemistry in the Department of Chemistry at the University of Manchester. He was previously the Forbes Chair of Organic Chemistry at the University of Edinburgh (2001–2012) and Professor of Synthetic Chemistry at the University of Warwick (1998–2001). Education Leigh was educated at Codsall Community High School and the University of Sheffield. Career and research He is noted for the invention of fundamental methods to control molecular-level dynamics and entanglement, including strategies to construct rotaxanes, catenanes and molecular knots and some of the earliest synthetic molecular motors, molecular robots and functional nanomachines. Using mechanically-interlocked molecular architectures he prepared a novel molecular information ratchet that employs a mechanism reminiscent of Maxwell's demon (although it requires an energ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rotaxane
In chemistry, a rotaxane () is a mechanically interlocked molecular architecture consisting of a dumbbell-shaped molecule which is threaded through a macrocycle (see graphical representation). The two components of a rotaxane are kinetically trapped since the ends of the dumbbell (often called ''stoppers'') are larger than the internal diameter of the ring and prevent dissociation (unthreading) of the components since this would require significant distortion of the covalent bonds. Much of the research concerning rotaxanes and other mechanically interlocked molecular architectures, such as catenanes, has been focused on their efficient synthesis or their utilization as artificial molecular machines. However, examples of rotaxane substructure have been found in naturally occurring peptides, including: cystine knot peptides, cyclotides or lasso-peptides such as microcin J25. Synthesis The earliest reported synthesis of a rotaxane in 1967 relied on the statistical probabi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
