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Sulfapyridine
Sulfapyridine (INN; also known as sulphapyridine) is a sulfanilamide antibacterial medication. At one time, it was commonly referred to as M&B 693. Sulfapyridine is no longer prescribed for treatment of infections in humans. However, it may be used to treat linear IgA disease and has use in veterinary medicine. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis, and this, rather than the development of resistance by bacteria, is the main reason for its decline in use. History Sulfapyridine was one of the first generation of sulfonamide antibiotics. It was first synthesised by chemist Montague Phillips, working under director of research Arthur Ewins at the British firm May & Baker Ltd, Dagenham on 2 November 1937. This sample was recorded in their test log as T69 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfasalazine
Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first-line treatment in rheumatoid arthritis. It is taken by mouth or can be administered rectally. Significant side effects occur in about 25% of people. Commonly these include loss of appetite, nausea, headache, and rash. Severe side effects include bone marrow suppression, liver problems, Stevens–Johnson syndrome, and kidney problems. It should not be used in people allergic to aspirin or sulfonamide. Use during pregnancy appears to be safe for the baby. Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works. One proposed mechanism is the inhibition of prostaglandins, resulting in local anti-inflammatory effects in the colon. The medication is broken down by intestinal bacteria into sulfapyridine and 5-ami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montague Phillips (chemist)
Montague Alexander Phillips (1 December 1902 - 12 October 1972) was an English Chemical industry, industrial chemist and chemical engineer. He is notable for the synthesis of the drug Sulfapyridine, sulphapyridine in 1937, while working as a research chemist at May & Baker, Dagenham, Essex. Sulphapyridine (also known as sulfapyridine, T693, Sulfapyridine, M&B 693 and Sulfapyridine, Dagenan) was an early antimicrobial/antibiotic and the first effective treatment for pneumonia, meningitis and various other bacterial infections of humans and animals. As such, it saved many tens of thousands of lives globally in the years before penicillin and other antibiotics became generally available. In the 1960s, Phillips was a key whistleblower in the thalidomide scandal. Education and qualifications Phillips attended the The John Roan School, John Roan School, Greenwich. At 18 he joined May & Baker, Battersea as a laboratory assistant while taking evening classes at Battersea Polytechnic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mesalamine
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is generally used for mildly to moderately severe disease. It is taken by mouth or rectally. The formulations which are taken by mouth appear to be similarly-effective. Common side-effects include headache, nausea, abdominal pain, and fever. Serious side-effects may include pericarditis, liver problems, and kidney problems. Use in pregnancy and breastfeeding appears safe. In people with a sulfa allergy certain formulations may result in problems. Mesalazine is an aminosalicylate and anti-inflammatory. It works by direct contact with the intestines. Mesalazine was approved for medical use in the United States in 1987. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2021, it was the 239th most commonly prescribed medication in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linear IgA Bullous Dermatosis
Linear IgA bullous dermatosis is a rare immune-mediated blistering skin disease frequently associated with medication exposure, especially vancomycin, with men and women being equally affected.James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. . It was first described by Tadeusz Chorzelski in 1979 and may be divided into two types:Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . Adult linear IgA disease is an acquired, autoimmune blistering disease that may present with a clinical pattern of vesicles indistinguishable from dermatitis herpetiformis, or with vesicles and bullae in a bullous pemphigoid-like appearance. This disease can often be difficult to treat even with usually effective medications such as rituximab. Childhood linear IgA disease (also known as "Chronic bullous disease of childhood") is an acquired, self-limited bullous disease t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pneumococcal
''Streptococcus pneumoniae'', or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic member of the genus ''Streptococcus''. ''S. pneumoniae'' cells are usually found in pairs (diplococci) and do not form spores and are non motile. As a significant human pathogenic bacterium ''S. pneumoniae'' was recognized as a major cause of pneumonia in the late 19th century, and is the subject of many humoral immunity studies. ''Streptococcus pneumoniae'' resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity. However, in susceptible individuals with weaker immune systems, such as the elderly and young children, the bacterium may become pathogenic and spread to other locations to cause disease. It spreads by direct person-to-person contact via respiratory droplets and by auto inoculation in persons carrying the bacteria in their upper respiratory tracts. It can be a cause of neonatal infections. ''Streptococcus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azo Compound
Azo compounds are organic compounds bearing the functional group diazenyl (, in which R and R′ can be either aryl or alkyl groups). IUPAC defines azo compounds as: "Derivatives of diazene (diimide), , wherein both hydrogens are substituted by hydrocarbyl groups, e.g. azobenzene or diphenyldiazene.", where Ph stands for phenyl group. The more stable derivatives contain two aryl groups. The group is called an ''azo group'' (, ). Many textile and leather articles are dyed with azo dyes and pigments. Aryl azo compounds urinary tract infections">Phenazopyridine, an aryl azo compound, is used to treat urinary tract infections">150px Aryl azo compounds are usually stable, crystalline species. Azobenzene is the prototypical aromatic azo compound. It exists mainly as the Cis-trans isomerism, ''trans'' isomer, but upon illumination, converts to the Cis-trans isomerism, ''cis'' isomer. Aromatic azo compounds can be synthesized by azo coupling, which entails an electrophilic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. rubens''. Most penicillins in clinical use are synthesised by ''Penicillium chrysogenum, P. chrysogenum'' using industrial fermentation, deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: benzylpenicillin, penicillin G (intramuscular injection, intramuscular or Intravenous therapy, intravenous use) and phenoxymethylpenicillin, penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococcus, staphylococci and streptococcus, streptococci. They are still widely used today for various bacterial infections, though many types of bacteria have developed antibiotic res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Winston Churchill
Sir Winston Leonard Spencer Churchill (30 November 1874 – 24 January 1965) was a British statesman, military officer, and writer who was Prime Minister of the United Kingdom from 1940 to 1945 (Winston Churchill in the Second World War, during the Second World War) and again from 1951 to 1955. For some 62 of the years between 1900 and 1964, he was a Member of Parliament (United Kingdom), member of parliament (MP) and represented a total of five Constituencies of the Parliament of the United Kingdom, constituencies over that time. Ideologically an adherent to economic liberalism and imperialism, he was for most of his career a member of the Conservative Party (UK), Conservative Party, which he led from 1940 to 1955. He was a member of the Liberal Party (UK), Liberal Party from 1904 to 1924. Of mixed English and American parentage, Churchill was born in Oxfordshire into the wealthy, aristocratic Spencer family. He joined the British Army in 1895 and saw action in British R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SS Assyrian (1914)
SS ''Assyrian'' was a cargo ship that was built in Hamburg for German owners in 1914, transferred to British owners in 1920 as war reparations and sunk by a U-boat in 1940. She was launched as MS ''Fritz'', and when she changed owners in 1920 she was renamed MS ''Assyrian''. She had been built as a motor ship but in 1925 she was converted to a steamship and became SS ''Assyrian''. From MS ''Fritz'' to SS ''Assyrian'' Blohm + Voss of Hamburg built the ship, completing her as MS ''Fritz'' in August 1914 for Woermann-Linie, who registered her in Hamburg. In 1919 she was designated for war reparations and in 1920 she was acquired by the British Ellerman and Papayanni Lines, who renamed her ''Assyrian'' and registered her in Liverpool. In 1925 Ellerman's had her converted from diesel to steam propulsion with a pair of three-cylinder triple-expansion steam engines built by Cooper and Greig of Dundee, Scotland and rated at a combined power output of 280 NHP. Steam came from a pair ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMS Leith (U36)
HMS ''Leith'' was a sloop of the Royal Navy that served in the Second World War. Building, commissioning and early service ''Leith'' was ordered on 1 November 1932 under the 1931 Programme. She was laid down at Devonport Dockyard on 6 February 1933, launched on 9 September 1933 and commissioned on 10 July 1934. She was initially assigned to the New Zealand Division of the Royal Navy, manned by the Chatham Port Division. ''Leith'' arrived at Auckland on 13 November 1934, and was deployed in the Pacific and locally in New Zealand waters. She was recommissioned in December 1936 in order to continue to serve with the New Zealand Division and was again in July 1939. She had an active career in the Pacific, making numerous visits to Colonial possessions, and on one occasion taking Salote Tupou III, Queen of Tonga on a visit to outlying islands. Wartime career The Pacific and return to the UK The outbreak of the Second World War saw ''Leith'' still in the Pacific. In September ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convoy SC 7
Convoy SC 7 was the name of a large Allied convoy in the Second World War comprising 35 merchant ships and six escorts. The convoy sailed eastwards from Sydney, Nova Scotia, for Liverpool and other British ports on 5 October 1940. While crossing the Atlantic, the convoy was attacked by one of the first U-boat wolfpacks. The escorts were overwhelmed, twenty of the 35 cargo vessels were sunk and two were damaged, with 141 lives lost. The disaster demonstrated the potency of wolfpacks (attacking in numbers) and the inadequacy of British anti-submarine operations. Ships of the convoy The slow Convoy SC 7 left Sydney, Nova Scotia on 5 October 1940 bound for Liverpool and other British ports. The convoy was to make but several merchant ships were much slower, reducing its speed. The convoy consisted of older, smaller ships, mostly with cargoes of bulk goods. Much of the freight on these ships originated on Canada's east coast, especially from points to the north and east of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
