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Montague Phillips (chemist)
Montague Alexander Phillips (1 December 1902 - 12 October 1972) was an English Chemical industry, industrial chemist and chemical engineer. He is notable for the synthesis of the drug Sulfapyridine, sulphapyridine in 1937, while working as a research chemist at May & Baker, Dagenham, Essex. Sulphapyridine (also known as sulfapyridine, T693, Sulfapyridine, M&B 693 and Sulfapyridine, Dagenan) was an early antimicrobial/antibiotic and the first effective treatment for pneumonia, meningitis and various other bacterial infections of humans and animals. As such, it saved many tens of thousands of lives globally in the years before penicillin and other antibiotics became generally available. In the 1960s, Phillips was a key whistleblower in the thalidomide scandal. Education and qualifications Phillips attended the The John Roan School, John Roan School, Greenwich. At 18 he joined May & Baker, Battersea as a laboratory assistant while taking evening classes at Battersea Polytechnic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Institute Of Chemistry
The Royal Institute of Chemistry was a British scientific organisation. Founded in 1877 as the Institute of Chemistry of Great Britain and Ireland (ICGBI), its role was to focus on qualifications and the professional status of chemists, and its aim was to ensure that consulting and analytical chemists were properly trained and qualified. The society received its first Royal Charter on 13 June 1885, and King George VI awarded the society royal patronage with effect from 14 May 1943, from which date it became the Royal Institute of Chemistry of Great Britain and Ireland (RICGBI). This re-designation was formally confirmed by the grant of a Supplemental Charter on 29 March 1944. As well as insisting on thorough professional qualifications, it also laid down strict ethical standards. Its main qualifications were Licentiate (LRIC) (professional training following a course of practical study to a standard lower than an honours degree), Graduate (GRIC) (completion of study equivalent t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfapyridine
Sulfapyridine (INN; also known as sulphapyridine) is a sulfanilamide antibacterial medication. At one time, it was commonly referred to as M&B 693. Sulfapyridine is no longer prescribed for treatment of infections in humans. However, it may be used to treat linear IgA disease and has use in veterinary medicine. It is a good antibacterial drug, but its water solubility is very pH dependent. Thus there is a risk of crystallization within the bladder or urethra, which could lead to pain or blockage. As with other sulfonamides, there is a significant risk of agranulocytosis, and this, rather than the development of resistance by bacteria, is the main reason for its decline in use. History Sulfapyridine was one of the first generation of sulfonamide antibiotics. It was first synthesised by chemist Montague Phillips, working under director of research Arthur Ewins at the British firm May & Baker Ltd, Dagenham on 2 November 1937. This sample was recorded in their test log as T69 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Battersea
Battersea is a large district in southwest London, part of the London Borough of Wandsworth, England. It is centred southwest of Charing Cross and also extends along the south bank of the Thames Tideway. It includes the Battersea Park. History Battersea is mentioned in the few surviving Anglo-Saxon geographical accounts as and later . As with many former parishes beside tidal flood plains the lowest land was reclaimed for agriculture by draining marshland and building culverts for streams. By the side of this was the River Heathwall, Heathwall tide mill in the north-east with a very long mill pond regularly draining and filling to the south. Battersea () appears in the Domesday Book of 1086 in Surrey within the Hundred (county division), hundred of Hundred_of_Brixton, Brixton () as a vast manor held by St Peter's Abbey, Westminster. Its ''Domesday'' assets were: 18 hide (unit), hides and 17 ploughlands of cultivated land; 7 gristmill, mills worth £42 9s 8d per year, of m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Greenwich
Greenwich ( , , ) is an List of areas of London, area in south-east London, England, within the Ceremonial counties of England, ceremonial county of Greater London, east-south-east of Charing Cross. Greenwich is notable for its maritime history and for giving its name to the Prime meridian (Greenwich), Greenwich Meridian (0° longitude) and Greenwich Mean Time. The town became the site of a royal palace, the Palace of Placentia, from the 15th century and was the birthplace of many House of Tudor, Tudors, including Henry VIII of England, Henry VIII and Elizabeth I. The palace fell into disrepair during the English Civil War and was demolished, eventually being replaced by the Greenwich Hospital (London), Royal Naval Hospital for Sailors, designed by Sir Christopher Wren and his assistant Nicholas Hawksmoor. These buildings became the Old Royal Naval College, Royal Naval College in 1873, and they remained a military education establishment until 1998, when they passed into the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The John Roan School
The John Roan School is a co-educational comprehensive secondary school and sixth form located in Greenwich, south-east London, England. History Grammar schools The current school was originally two grammar schools. The boys' school was founded in 1677 and the girls' school in 1877 through a charitable endowment by John Roan, Yeoman of Harriers to King Charles I, who left a substantial amount in his Will: :"to bring up so many poor town-born children of Greenwich at school, that is to reading, writing, and cyphering, and each of them forty shillings towards their clothing until each of them shall accomplish the age of fifteen years. The said poor children shall wear on their upper garment the cognisance or crest of me, John Roan." The stag's head badge – derived from John Roan's coat-of-arms – has been worn by Roan schoolchildren ever since. The first chairman of the governors of the school was Dr Thomas Plume, the vicar of Greenwich. For much of the 18th century, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thalidomide Scandal
In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands of miscarriages. Thalidomide was introduced in 1957 as a tranquilizer, and was later marketed by the German pharmaceutical company Chemie Grünenthal under the trade name Contergan as a medication for anxiety, trouble sleeping, tension, and morning sickness. It was introduced as a sedative and medication for morning sickness without having been tested on pregnant women. While initially deemed to be safe in pregnancy, concerns regarding birth defects were noted in 1961, and the medication was removed from the market in Europe that year. Development of thalidomide Thalidomide was first developed as a tranquilizer by Swiss pharmaceuti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Whistleblower
Whistleblowing (also whistle-blowing or whistle blowing) is the activity of a person, often an employee, revealing information about activity within a private or public organization that is deemed illegal, immoral, illicit, unsafe, unethical or fraudulent. Whistleblowers can use a variety of internal or external channels to communicate information or allegations. Over 83% of whistleblowers report internally to a supervisor, human resources, compliance, or a neutral third party within the company, hoping that the company will address and correct the issues. A whistleblower can also bring allegations to light by communicating with external entities, such as the media, government, or law enforcement. Some countries legislate as to what constitutes a protected disclosure, and the permissible methods of presenting a disclosure. Whistleblowing can occur in the private sector or the public sector. Whistleblowers often face retaliation for their disclosure, including termination of emp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. rubens''. Most penicillins in clinical use are synthesised by ''Penicillium chrysogenum, P. chrysogenum'' using industrial fermentation, deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: benzylpenicillin, penicillin G (intramuscular injection, intramuscular or Intravenous therapy, intravenous use) and phenoxymethylpenicillin, penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococcus, staphylococci and streptococcus, streptococci. They are still widely used today for various bacterial infections, though many types of bacteria have developed antibiotic res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacterial Infections
Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and many are beneficial but others can cause infectious diseases. The number of these pathogenic species in humans is estimated to be fewer than a hundred. By contrast, several thousand species are considered part of the gut flora, with a few hundred species present in each individual human's digestive tract. The body is continually exposed to many species of bacteria, including beneficial commensals, which grow on the skin and mucous membranes, and saprophytes, which grow mainly in the soil and in decaying matter. The blood and tissue fluids contain nutrients sufficient to sustain the growth of many bacteria. The body has defence mechanisms that enable it to resist microbial invasion of its tissues and give it a natural immunity or innate resistance against many microorganisms. Pathogenic bacteria are speciall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meningitis
Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. The most common symptoms are fever, intense headache, vomiting and neck stiffness and occasionally photophobia. Other symptoms include confusion or altered consciousness, nausea, and an inability to tolerate loud noises. Young children often exhibit only nonspecific symptoms, such as irritability, drowsiness, or poor feeding. A non-blanching rash (a rash that does not fade when a glass is rolled over it) may also be present. The inflammation may be caused by infection with viruses, bacteria, fungi or parasites. Non-infectious causes include malignancy (cancer), subarachnoid hemorrhage, chronic inflammatory disease ( sarcoidosis) and certain drugs. Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. A lumba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pneumonia
Pneumonia is an Inflammation, inflammatory condition of the lung primarily affecting the small air sacs known as Pulmonary alveolus, alveoli. Symptoms typically include some combination of Cough#Classification, productive or dry cough, chest pain, fever, and Shortness of breath, difficulty breathing. The severity of the condition is variable. Pneumonia is usually caused by infection with viruses or bacteria, and less commonly by other microorganisms. Identifying the responsible pathogen can be difficult. Diagnosis is often based on symptoms and physical examination. Chest X-rays, blood tests, and Microbiological culture, culture of the sputum may help confirm the diagnosis. The disease may be classified by where it was acquired, such as community- or hospital-acquired or healthcare-associated pneumonia. Risk factors for pneumonia include cystic fibrosis, chronic obstructive pulmonary disease (COPD), sickle cell disease, asthma, diabetes, heart failure, a history of smoking, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, treatment and antibiotic prophylaxis, prevention of such infections. They may either bactericide, kill or bacteriostatic agent, inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza. Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi. Drugs which inhibit growth of fungi are called antifungal drugs. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek language, Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
