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Phenpromethamine
Phenpromethamine (former brand name Vonedrine), also known as ''N'',β-dimethylphenethylamine (MPPA, BMMPEA, β-Me-NMPEA, β,''N''-MePEA), is a sympathomimetic nasal decongestant of the phenethylamine group. It was previously marketed as a nasal inhaler from 1943 through 1960 but is no longer available. The medication is a stimulant and is banned by the World Anti-Doping Agency. It has been detected in dietary supplements starting in the 2010s. The drug is a monoamine releasing agent (MRA) similarly to β-phenethylamine, amphetamine, and other phenethylamines. It is the ''N''-methyl derivative of β-methylphenethylamine (BMPEA) and the β-methyl derivative of ''N''-methylphenethylamine (NMPEA). Phenpromethamine is known to act as a norepinephrine–dopamine releasing agent (NDRA), with values of 154nM for norepinephrine and 574nM for dopamine in rat brain synaptosomes, whereas serotonin was not reported. See also * β,''N'',''N''-Trimethylphenethylamine * Methamphetamine (Π... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
β,N,N-Trimethylphenethylamine
β,''N'',''N''-Trimethylphenethylamine, also known as ''N'',''N''-dimethyl-2-phenylpropan-1-amine (''N'',''N''-DMPPA or DMPPA) is a monoamine releasing agent of the phenethylamine family. It is the ''N''-methyl derivative of phenpromethamine (β,''N''-methylphenethylamine) and the ''N'',''N''-dimethyl derivative of β-methylphenethylamine. The drug is a partial norepinephrine releasing agent, with an of 1,337nM and an of 67% in rat brain synaptosomes. Conversely, it was inactive on dopamine, whereas serotonin was not reported. The drug produces non-significant increases in blood pressure in rodents, but does not affect heart rate or affect locomotor activity. It may be rapidly metabolized and thereby inactivated. DMPPA was first described in the scientific literature by at least 2019. See also * β-Methylamphetamine 2-Phenyl-3-aminobutane (also known as β-methylamphetamine) is a stimulant of the phenethylamine class that is closely related to its α-methyl analog Pento ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |