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Oskar (gene)
''oskar'' is a gene required for the development of the ''Drosophila'' embryo. It defines the Posterior (anatomy), posterior pole during early Drosophila embryogenesis, embryogenesis. Its two isoforms, short and long, play different roles in Drosophila embryonic development. ''oskar'' was named after the main character from the Günter Grass novel The Tin Drum, who refuses to grow up. Evolutionary history ''oskar'' displays a unique evolutionary origin resulting from a Horizontal_gene_transfer, Horizontal Domain Transfer from a probably bacterial endosymbiont onto an ancestral insect genome. The OSK domain is of bacterial origin and fused with the LOTUS domain through a linker domain. This event must have happened just prior to the divergence with the Crustacean, the insect's sister group, as ''oskar'' can be found as early as the Zygentoma but does not seem to exist in Crustacean. Translational-level regulation ''oskar'' is translationally repressed prior to reaching the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cup (protein)
A cup is an open-top vessel (container) used to hold liquids for drinking, typically with a flattened Hemisphere (geometry), hemispherical shape, and often with a capacity of about . Cups may be made of pottery (including porcelain), glass, metal, wood, stone, polystyrene, plastic, lacquerware, or other materials. Normally, a cup is brought in contact with the mouth for drinking, distinguishing it from other tableware and drinkware forms such as jugs. They also most typically have Handle (grip), handles, though a beaker has no handle or stem, and small bowl shapes are very common in Asia. Cups of different styles may be used for different types of liquids or other foodstuffs (e.g. teacups and measuring cups), in different situations (e.g. at water stations or in Ceremony, ceremonies and rituals), or for decorative arts, decoration.#R1, Rigby 2003: p. 573–574. The history of cups goes back well into prehistory, initially mostly as handle-less beakers or bowls, and they hav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vasa Gene
''Vasa'' is an RNA binding protein with an ATP-dependent RNA helicase that is a member of the DEAD box family of proteins. The vasa gene is essential for germ cell development and was first identified in ''Drosophila melanogaster'', but has since been found to be conserved in a variety of vertebrates and invertebrates including humans. The Vasa protein is found primarily in germ cells in embryos and adults, where it is involved in germ cell determination and function, as well as in multipotent stem cells, where its exact function is unknown. Gene The Vasa gene is a member of the DEAD box family of RNA helicases in ''Drosophila melanogaster.'' Its human ortholog, Ddx4, is located on human chromosome 5q. It is syntenic to mouse chromosome 13, where the mouse vasa gene is located. The gene is conserved in many invertebrates and vertebrate species such as ''Caenorhabditis elegans'', ''Xenopus'', Zebrafish, flatworms, echinoderms, molluscs, nematodes, mice and rats as an important par ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TDRD7
Tudor domain-containing protein 7 is a protein that in humans is encoded by the ''TDRD7'' gene. In melanocytic cells TDRD7 gene expression may be regulated by MITF. Gene polymorphism Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown. Interactions TDRD7 has been shown to interact with TACC1 Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the ''TACC1'' gene. Function The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer .... References Further reading * * * * * * External links * * {{gene-9-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helix-turn-helix
Helix-turn-helix is a DNA-binding domain (DBD). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates two alpha helix, α helices, joined by a short strand of amino acids, that bind to the major groove of DNA. The HTH motif occurs in many proteins that regulate gene expression. It should not be confused with the helix–loop–helix motif. Discovery The discovery of the helix-turn-helix motif was based on similarities between several genes encoding Transcription (genetics), transcription regulatory proteins from bacteriophage lambda and ''Escherichia coli'': Cro, Catabolite activator protein, CAP, and cI protein, λ repressor, which were found to share a common 20–25 amino acid sequence that facilitates DNA recognition. Function The helix-turn-helix motif is a DNA-binding motif. The recognition and binding to DNA by helix-turn-helix proteins is done by the two α helices, one occupying the N-terminus, N-terminal end of the mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudoenzyme
Pseudoenzymes are variants of enzymes that are catalytically-deficient (usually inactive), meaning that they perform little or no enzyme catalysis. They are believed to be represented in all major enzyme families in the kingdoms of life, where they have important signaling and metabolic functions, many of which are only now coming to light. Pseudoenzymes are becoming increasingly important to analyse, especially as the bioinformatic analysis of genomes reveals their ubiquity. Their important regulatory and sometimes disease-associated functions in metabolic and signalling pathways are also shedding new light on the non-catalytic functions of active enzymes, of moonlighting proteins, the re-purposing of proteins in distinct cellular roles ( Protein moonlighting). They are also suggesting new ways to target and interpret cellular signalling mechanisms using small molecules and drugs. The most intensively analyzed, and certainly the best understood pseudoenzymes in terms of cellula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA-binding Protein
RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cell (biology), cells and participate in forming ribonucleoprotein complexes. RBPs contain various structural motifs, such as RNA recognition motif (RRM), dsRNA binding domain, zinc finger and others. They are cytoplasmic and cell nucleus, nuclear proteins. However, since most mature RNA is exported from the nucleus relatively quickly, most RBPs in the nucleus exist as complexes of protein and Precursor mRNA, pre-mRNA called heterogeneous ribonucleoprotein particles (hnRNPs). RBPs have crucial roles in various cellular processes such as: cellular function, transport and localization. They especially play a major role in post-transcriptional control of RNAs, such as: RNA splicing, splicing, polyadenylation, mRNA stabilization, mRNA Subcellular localization, localization and Translation (biology), translation. Eukaryote, Eukaryotic cells express diverse RBPs with unique RN ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribosome
Ribosomes () are molecular machine, macromolecular machines, found within all cell (biology), cells, that perform Translation (biology), biological protein synthesis (messenger RNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA molecules and many ribosomal proteins (). The ribosomes and associated molecules are also known as the ''translational apparatus''. Overview The sequence of DNA that encodes the sequence of the amino acids in a protein is transcribed into a messenger RNA (mRNA) chain. Ribosomes bind to the messenger RNA molecules and use the RNA's sequence of nucleotides to determine the sequence of amino acids needed to generate a protein. Amino acids are selected and carried to the ribosome by transfer RNA (tRNA) molecules, which enter the riboso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barentsz (protein)
Willem Barentsz (; – 20 June 1597), anglicized as William Barents or Barentz, was a Dutch navigator, cartographer, and Arctic explorer. Barentsz went on three expeditions to the far north in search for a Northeast passage. He reached as far as Novaya Zemlya and the Kara Sea in his first two voyages, but was turned back on both occasions by ice. During a third expedition, the crew discovered Spitsbergen and Bear Island, but subsequently became stranded on Novaya Zemlya for almost a year. Barentsz died on the return voyage in 1597. The Barents Sea, among many other places, is named after him. Life and career Willem Barentsz was born around 1550 in the village Formerum on the island Terschelling in the Seventeen Provinces, present-day Netherlands. ''Barentsz'' was not his surname but rather his patronymic name, short for ''Barentszoon'' " Barent's son". A cartographer by trade, Barentsz sailed to Spain and the Mediterranean to complete an atlas of the Mediterranean region, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EIF4E
Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein in humans encoded by the ''EIF4E'' gene. eIF4E plays a central role in translation initiation and is involved in regulating protein synthesis. Its activity influences a range of biological processes and disease states, making it an important target for therapeutic development, particularly in disorders characterized by aberrant protein production. Discovery eIF4E was discovered as a cytoplasmic cap binding protein functioning in translation by Witold Filipowicz at al. In 1976. Two years later, in 1978, Sonenberg et al. confirmed Filipowicz et al.’s findings by repeating the same experiments and adding a crosslinking chemical to increase the stability of the mRNA-protein complex. This has been confirmed by numerous scientists in their published articles such as Katherine L. B. Borden, Michael J. Osborne and Katherine L.B. Borden. Structure Most eukaryote, eukaryotic cellular Messenger RNA, mRNAs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bruno Response Elements
Bruno may refer to: People and fictional characters * Bruno (name), including lists of people and fictional characters with either the given name or surname * Bruno, Duke of Saxony (died 880) * Bruno the Great (925–965), Archbishop of Cologne, Duke of Lotharingia and saint * Bruno (bishop of Verden) (920–976), German Roman Catholic bishop * Pope Gregory V (c. 972–999), born Bruno of Carinthia * Bruno of Querfurt (c. 974–1009), Christian missionary bishop, martyr and saint * Bruno of Augsburg (c. 992–1029), Bishop of Augsburg * Bruno (bishop of Würzburg) (1005–1045), German Roman Catholic bishop * Pope Leo IX (1002–1054), born Bruno of Egisheim-Dagsburg * Bruno II (1024–1057), Frisian count or margrave * Bruno the Saxon (fl. 2nd half of the 11th century), historian * Saint Bruno of Cologne (d. 1101), founder of the Carthusians * Bruno (bishop of Segni) (c. 1045–1123), Italian Roman Catholic bishop and saint * Bruno (archbishop of Trier) (died 1124), German Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
