Optical Tomography
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Optical Tomography
Optical tomography is a form of computed tomography that creates a digital volumetric model of an object by reconstructing images made from light transmitted and scattered through an object. Optical tomography is used mostly in medical imaging research. Optical tomography in industry is used as a sensor of thickness and internal structure of semiconductors. Principle Optical tomography relies on the object under study being at least partially light-transmitting or translucent, so it works best on soft tissue, such as breast and brain tissue. The high scatter-based attenuation involved is generally dealt with by using intense, often pulsed or intensity modulated, light sources, and highly sensitive light sensors, and the use of infrared light at frequencies where body tissues are most transmissive. Soft tissues are highly scattering but weakly absorbing in the near-infrared and red parts of the spectrum, so that this is the wavelength range usually used. Types Diffuse optical tom ...
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Computed Tomography
A computed tomography scan (CT scan), formerly called computed axial tomography scan (CAT scan), is a medical imaging technique used to obtain detailed internal images of the body. The personnel that perform CT scans are called radiographers or radiology technologists. CT scanners use a rotating X-ray tube and a row of detectors placed in a gantry to measure X-ray attenuations by different tissues inside the body. The multiple X-ray measurements taken from different angles are then processed on a computer using tomographic reconstruction algorithms to produce tomographic (cross-sectional) images (virtual "slices") of a body. CT scans can be used in patients with metallic implants or pacemakers, for whom magnetic resonance imaging (MRI) is contraindicated. Since its development in the 1970s, CT scanning has proven to be a versatile imaging technique. While CT is most prominently used in medical diagnosis, it can also be used to form images of non-living objects. The 1979 N ...
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Deconvolution
In mathematics, deconvolution is the inverse of convolution. Both operations are used in signal processing and image processing. For example, it may be possible to recover the original signal after a filter (convolution) by using a deconvolution method with a certain degree of accuracy. Due to the measurement error of the recorded signal or image, it can be demonstrated that the worse the signal-to-noise ratio (SNR), the worse the reversing of a filter will be; hence, inverting a filter is not always a good solution as the error amplifies. Deconvolution offers a solution to this problem. The foundations for deconvolution and time-series analysis were largely laid by Norbert Wiener of the Massachusetts Institute of Technology in his book ''Extrapolation, Interpolation, and Smoothing of Stationary Time Series'' (1949). The book was based on work Wiener had done during World War II but that had been classified at the time. Some of the early attempts to apply these theories were in ...
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Computed Tomography Laser Mammography
Computed tomography laser mammography (CTLM) is the trademark of Imaging Diagnostic Systems, Inc. (IDSI, United States) for its Optical tomography, optical tomographic technique for female breast imaging. This medical imaging technique uses laser energy in the near-infrared region of the spectrum to detect angiogenesis in the breast tissue. It is optical molecular imaging for hemoglobin, both oxygenated and deoxygenated. The technology uses laser in the same way computed tomography uses X-rays; the beams travel through tissue and suffer attenuation. A laser detector measures the intensity drop and the data is collected as the laser detector moves across the breast creating a tomography image. CTLM images show hemoglobin distribution in a tissue and can detect areas of angiogenesis surrounding malignant tumors, that stimulate this angiogenesis to obtain nutrients for growth. History Breast cancer affects 1 in 8 women, and an estimated 27% of people live at least 5 years after b ...
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Diffuse Optical Imaging
Diffuse optical imaging (DOI) is a method of imaging using near-infrared spectroscopy (NIRS) or fluorescence-based methods. When used to create 3D volumetric models of the imaged material DOI is referred to as diffuse optical tomography, whereas 2D imaging methods are classified as diffuse optical imaging. The technique has many applications to neuroscience, sports medicine, wound monitoring, and cancer detection. Typically DOI techniques monitor changes in concentrations of oxygenated and deoxygenated hemoglobin and may additionally measure redox states of cytochromes. The technique may also be referred to as diffuse optical tomography (DOT), near infrared optical tomography (NIROT) or fluorescence diffuse optical tomography (FDOT), depending on the usage. In neuroscience, functional measurements made using NIR wavelengths, DOI techniques may classify as functional near infrared spectroscopy fNIRS. Physical mechanism Biological tissues can be considered strongly diffusive med ...
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Optical Coherence Tomography
Optical coherence tomography (OCT) is a high-resolution imaging technique with most of its applications in medicine and biology. OCT uses coherent near-infrared light to obtain micrometer-level depth resolved images of biological tissue or other scattering media. It uses interferometry techniques to detect the amplitude and time-of-flight of reflected light. OCT uses transverse sample scanning of the light beam to obtain two- and three-dimensional images. Short-coherence-length light can be obtained using a superluminescent diode (SLD) with a broad spectral bandwidth or a broadly tunable laser with narrow linewidth. The first demonstration of OCT imaging (in vitro) was published by a team from MIT and Harvard Medical School in a 1991 article in the journal ''Science (journal), Science''. The article introduced the term "OCT" to credit its derivation from optical coherence-domain reflectometry, in which the axial resolution is based on temporal coherence. The first demonstrat ...
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Confocal Time-of-flight Diffuse Optical Tomography
In geometry, confocal means having the same foci: confocal conic sections. * For an optical cavity consisting of two mirrors, confocal means that they share their foci. If they are identical mirrors, their radius of curvature, ''R''mirror, equals ''L'', where ''L'' is the distance between the mirrors. * In conic section A conic section, conic or a quadratic curve is a curve obtained from a cone's surface intersecting a plane. The three types of conic section are the hyperbola, the parabola, and the ellipse; the circle is a special case of the ellipse, tho ...s, it is said of two ellipses, two hyperbolas, or an ellipse and a hyperbola which share both foci with each other. If an ellipse and a hyperbola are confocal, they are perpendicular to each other. * In optics, it means that one Focus (optics), focus or image point of one lens is the same as one focus of the next lens (optics), lens. See also

*Confocal laser scanning microscopy *Confocal microscopy * {{set index ar ...
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Inverse Filter
Signal processing is an electrical engineering subfield that focuses on analysing, modifying, and synthesizing signals such as sound, images, and scientific measurements. For example, with a filter ''g'', an inverse filter ''h'' is one such that the sequence of applying ''g'' then ''h'' to a signal results in the original signal. Software or electronic inverse filters are often used to compensate for the effect of unwanted environmental filtering of signals. In speech science In all proposed models for the production of human speech, an important variable is the waveform of the airflow, or volume velocity, at the glottis. The glottal volume velocity waveform provides the link between movements of the vocal folds and the acoustical results of such movements, in that the glottis acts approximately as a source of volume velocity. That is, the impedance of the glottis is usually much higher than that of the vocal tract, and so glottal airflow is controlled mostly (but not entirely) ...
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Confocal
In geometry, confocal means having the same foci: confocal conic sections. * For an optical cavity consisting of two mirrors, confocal means that they share their foci. If they are identical mirrors, their radius of curvature, ''R''mirror, equals ''L'', where ''L'' is the distance between the mirrors. * In conic sections, it is said of two ellipses, two hyperbolas, or an ellipse and a hyperbola which share both foci with each other. If an ellipse and a hyperbola are confocal, they are perpendicular to each other. * In optics, it means that one focus or image point of one lens is the same as one focus of the next lens. See also *Confocal laser scanning microscopy *Confocal microscopy Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser scanning confocal microscopy (LSCM), is an optical imaging technique for increasing optical resolution and contrast (vision), contrast of a micrograph by me ... * {{set index article, mathematics Elementary geo ...
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Scattering
In physics, scattering is a wide range of physical processes where moving particles or radiation of some form, such as light or sound, are forced to deviate from a straight trajectory by localized non-uniformities (including particles and radiation) in the medium through which they pass. In conventional use, this also includes deviation of reflected radiation from the angle predicted by the law of reflection. Reflections of radiation that undergo scattering are often called ''diffuse reflections'' and unscattered reflections are called ''specular'' (mirror-like) reflections. Originally, the term was confined to light scattering (going back at least as far as Isaac Newton in the 17th century). As more "ray"-like phenomena were discovered, the idea of scattering was extended to them, so that William Herschel could refer to the scattering of "heat rays" (not then recognized as electromagnetic in nature) in 1800. John Tyndall, a pioneer in light scattering research, noted the connecti ...
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Digital Data
Digital data, in information theory and information systems, is information represented as a string of Discrete mathematics, discrete symbols, each of which can take on one of only a finite number of values from some alphabet (formal languages), alphabet, such as letters or digits. An example is a text document, which consists of a string of alphanumeric characters. The most common form of digital data in modern information systems is ''binary data'', which is represented by a string of binary digits (bits) each of which can have one of two values, either 0 or 1. Digital data can be contrasted with ''analog data'', which is represented by a value from a continuous variable, continuous range of real numbers. Analog data is transmitted by an analog signal, which not only takes on continuous values but can vary continuously with time, a continuous real-valued function of time. An example is the air pressure variation in a sound wave. The word ''digital'' comes from the same sour ...
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Diffusion Equation
The diffusion equation is a parabolic partial differential equation. In physics, it describes the macroscopic behavior of many micro-particles in Brownian motion, resulting from the random movements and collisions of the particles (see Fick's laws of diffusion). In mathematics, it is related to Markov processes, such as random walks, and applied in many other fields, such as materials science, information theory, and biophysics. The diffusion equation is a special case of the convection–diffusion equation when bulk velocity is zero. It is equivalent to the heat equation under some circumstances. Statement The equation is usually written as: \frac = \nabla \cdot \big D(\phi,\mathbf) \ \nabla\phi(\mathbf,t) \big where is the density of the diffusing material at location and time and is the collective diffusion coefficient for density at location ; and represents the vector differential operator del. If the diffusion coefficient depends on the density then the equatio ...
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Photon Diffusion
Photon diffusion is a situation where photons travel through a material without being absorbed, but rather undergoing repeated scattering events which change the direction of their path. The path of any given photon is then effectively a random walk. A large ensemble of such photons can be said to exhibit diffusion in the material, and can be described with a diffusion equation. Astrophysics In astrophysics, photon diffusion occurs inside a stellar atmosphere. To describe this phenomenon, one should develop the transfer equation in moments and use the Eddington approximation to radiative transfer (i.e. the diffusion approximation). In 3D the results are two equations for the photon energy flux: :\vec F = -\frac\vec \nabla U, :\vec \nabla \cdot \vec F = 0, where \sigma is the opacity. By substituting the first equation into the second, one obtains the diffusion equation for the photon energy density: :\nabla^2 U -\frac\vec \nabla U \cdot \vec \nabla \sigma=0. Medical science In me ...
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