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Kobophenol A
Kobophenol A is a stilbenoid. It is a tetramer of resveratrol. It can be isolated from '' Caragana chamlagu'',(+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase. Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim and Young Choong Kim, Biological & Pharmaceutical Bulletin, Vol. 25, 2002 from '''' [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetramer
A tetramer () (''tetra-'', "four" + '' -mer'', "parts") is an oligomer formed from four monomers or subunits. The associated property is called ''tetramery''. An example from inorganic chemistry is titanium methoxide with the empirical formula Ti(OCH3)4, which is tetrameric in solid state and has the molecular formula Ti4(OCH3)16. An example from organic chemistry is kobophenol A, a substance that is formed by combining four molecules of resveratrol. In biochemistry, it similarly refers to a biomolecule formed of four units, that are the same ( homotetramer), i.e. as in Concanavalin A or different ( heterotetramer), i.e. as in hemoglobin. Hemoglobin has 4 similar sub-units while immunoglobulins have 2 very different sub-units. The different sub-units may have each their own activity, such as binding biotin in avidin tetramers, or have a common biological property, such as the allosteric binding of oxygen Oxygen is a chemical element; it has chemical symbol, symbo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Resveratrol
Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol or polyphenol and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacterium, bacteria or fungus, fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts. Although commonly used as a dietary supplement and studied in laboratory models of human diseases, there is no evidence-based medicine, high-quality evidence that resveratrol improves longevity, lifespan or has a substantial effect on any human disease. Research Resveratrol has been studied for its potential therapeutic use, with little evidence of anti-disease effects or health benefits in humans. Cardiovascular disease There is no evidence of benefit from resveratrol in people who already have heart disease. A 2018 meta-analysis found no effect on systolic blood pressure, systolic or diastolic blood pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caragana Chamlagu
''Caragana sinica'' () is a species belonging to the genus ''Caragana''. ''Caragana sinica'' is known to produce the stilbenoid trimers α-viniferin, showing acetylcholinesterase inhibitory activity, and miyabenol C, a protein kinase C inhibitorNaturally Occurring Protein Kinase C Inhibitors; II. Isolation of Oligomeric Stilbenes from Caragana sinica. Palaniappan Kulanthaivel, William P. Janzen, Lawrence M. Ballas, Jack B. Jiang, Chang-Qi Hu, James W. Darges, Jan C. Seldin, Divann J. Cofield and Laurel M. Adams, Planta Med, 1995, 61(1), pages 41-44, and two stilbene tetramers kobophenol A, and carasinol B Carasinol B is a stilbenoid tetramer found in ''Caragana sinica'' (Chinese : Jin Que-gen). Acid-catalyzed epimerization of kobophenol A Kobophenol A is a stilbenoid. It is a tetramer of resveratrol. It can be isolated from '' Caragana chamlagu'', .... References Hedysareae Medicinal plants of Asia {{Faboideae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caragana Sinica
''Caragana sinica'' () is a species belonging to the genus ''Caragana''. ''Caragana sinica'' is known to produce the stilbenoid trimers alpha-viniferin, α-viniferin, showing acetylcholinesterase inhibitory activity, and miyabenol C, a protein kinase C inhibitorNaturally Occurring Protein Kinase C Inhibitors; II. Isolation of Oligomeric Stilbenes from Caragana sinica. Palaniappan Kulanthaivel, William P. Janzen, Lawrence M. Ballas, Jack B. Jiang, Chang-Qi Hu, James W. Darges, Jan C. Seldin, Divann J. Cofield and Laurel M. Adams, Planta Med, 1995, 61(1), pages 41-44, and two stilbene tetramers kobophenol A, and carasinol B. References Hedysareae Medicinal plants of Asia {{Faboideae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carex Folliculata
''Carex folliculata'', the northern long sedge, is a species of flowering plant in the family Cyperaceae. It is native to eastern Canada (and Saint Pierre and Miquelon Saint Pierre and Miquelon ( ), officially the Territorial Collectivity of Saint Pierre and Miquelon (), is a self-governing territorial overseas collectivity of France in the northwestern Atlantic Ocean, located near the Canada, Canadian prov ...), and the eastern United States (but in the southeast it is confined to the Appalachians). A clumping perennial reaching but usually shorter, it has broad, yellowish-green leaves. An obligate wetland species, it is found in a wide variety of wet habitats from sea level up to , and can handle acidic, neutral, and basic conditions. References folliculata Flora of Eastern Canada Flora of Wisconsin Flora of the Northeastern United States Flora of the Southeastern United States Taxa named by Carl Linnaeus Plants described in 1753 {{Carex-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase
Acetylcholinesterase (HUGO Gene Nomenclature Committee, HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalysis, catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters: : acetylcholine + H2O = choline + acetate It is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate cholinergic neurotransmission, synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. Enzyme structure and mechanism AChE is a hydrolase that hydrolyzes choline esters. It has a very high catalytic activity—each molecule of AChE degrades about 5,000 molecules of acetylcholine (ACh) per second, approaching the limit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epimerization
In stereochemistry, an epimer is one of a pair of diastereomers. The two epimers have opposite configuration at only one stereogenic center out of at least two. All other stereogenic centers in the molecules are the same in each. Epimerization is the interconversion of one epimer to the other epimer. Doxorubicin and epirubicin are two epimers that are used as drugs. Examples The stereoisomers β-D-glucopyranose and β-D- mannopyranose are epimers because they differ only in the stereochemistry at the C-2 position. The hydroxy group in β-D-glucopyranose is equatorial (in the "plane" of the ring), while in β-D-mannopyranose the C-2 hydroxy group is axial (up from the "plane" of the ring). These two molecules are epimers but, because they are not mirror images of each other, are not enantiomers. (Enantiomers have the same name, but differ in D and L classification.) They are also not sugar anomers, since it is not the anomeric carbon involved in the stereochemistry. Similarly, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carasinol B to carasinol B can be performed ''in vitro''.
Carasinol B is a stilbenoid tetramer found in ''Caragana sinica'' (Chinese : Jin Que-gen). Acid-catalyzed epimerization of kobophenol A Kobophenol A is a stilbenoid. It is a tetramer of resveratrol. It can be isolated from '' Caragana chamlagu'', References Resveratrol oligomers Natural phenol tetramers {{Aromatic-stub ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Resveratrol Oligomers
Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol or polyphenol and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts. Although commonly used as a dietary supplement and studied in laboratory models of human diseases, there is no evidence-based medicine, high-quality evidence that resveratrol improves longevity, lifespan or has a substantial effect on any human disease. Research Resveratrol has been studied for its potential therapeutic use, with little evidence of anti-disease effects or health benefits in humans. Cardiovascular disease There is no evidence of benefit from resveratrol in people who already have heart disease. A 2018 meta-analysis found no effect on systolic blood pressure, systolic or diastolic blood pressure; a sub-anal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Phenol Tetramers
Nature is an inherent character or constitution, particularly of the ecosphere or the universe as a whole. In this general sense nature refers to the laws, elements and phenomena of the physical world, including life. Although humans are part of nature, human activity or humans as a whole are often described as at times at odds, or outright separate and even superior to nature. During the advent of modern scientific method in the last several centuries, nature became the passive reality, organized and moved by divine laws. With the Industrial Revolution, nature increasingly became seen as the part of reality deprived from intentional intervention: it was hence considered as sacred by some traditions (Rousseau, American transcendentalism) or a mere decorum for divine providence or human history (Hegel, Marx). However, a vitalist vision of nature, closer to the pre-Socratic one, got reborn at the same time, especially after Charles Darwin. Within the various uses of the word t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
