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Iso-LSD
Iso-LSD, also known as ''d''-iso-LSD, (+)-iso-LSD, or (5''R''-8''S'')-LSD, as well as ''N'',''N''-diethylisolysergamide, is a serotonin receptor modulator of the substituted lysergamide, lysergamide family related to lysergic acid diethylamide (LSD). It is the 8-position epimer of LSD, with iso-LSD being 8α (8''S'') and LSD being 8β (8''R''). Iso-LSD is also the ''N'',''N''-diethyl chemical derivative, derivative of isoergine (isolysergic acid amide; iso-LSA), a constituent found in morning glory seeds. Iso-LSD is one of four possible stereoisomers of LSD. Use and effects According to Albert Hofmann and colleagues, iso-LSD is inactive as a psychedelic drug, psychedelic in humans at doses of up to 500μg, which is up to 25times the minimum given doses of LSD (i.e., 20–50μg).} In other sources, iso-LSD was also stated as being inactive at doses of up to 50μg/kg (3.5mg for a 70-kg person), whereas LSD is active at a dose of 1μg/kg (70μg for a 70-kg person). Hence, iso-LSD is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoergine
Isoergine, also known as isolysergic acid amide (iso-LSA or iso-LA-819), isolysergamide, or erginine, is a serotonergic psychedelic of the ergoline and lysergamide families related to ergine (lysergic acid amide; LSA) and lysergic acid diethylamide (LSD). It is the epimer of ergine inverted at the 8 position. Along with ergine and other ergolines, isoergine occurs naturally in morning glories. It is thought to be primarily responsible for the hallucinogenic effects of morning glory seeds. Use and effects Isoergine occurs naturally in morning glory species, including ''Ipomoea tricolor'' (tlitliltzin), ''Ipomoea corymbosa'' (ololiuhqui), and '' Argyreia nervosa'' (Hawaiian baby woodrose). It has been found to constitute 8 to 35% of total alkaloid content relative to 5 to 58% for ergine. Albert Hofmann, the discoverer of LSD's psychedelic effects, tried 2mg isoergine orally and experienced feelings of unreality, detachment from the outside world, feelings of mental emptiness ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysergide Stereoisomers Structural Formulae V
Lysergic acid diethylamide, commonly known as LSD (from German ; often referred to as acid or lucy), is a semisynthetic, hallucinogenic compound derived from ergot, known for its powerful psychological effects and serotonergic activity. It was historically significant in psychiatry and 1960s counterculture; it is currently legally restricted but experiencing renewed scientific interest and increasing use. When taken orally, LSD has an onset of action within 0.4 to 1.0 hours (range: 0.1–1.8 hours) and a duration of effect lasting 7 to 12 hours (range: 4–22 hours). It is commonly administered via tabs of blotter paper. LSD is extremely potent, with noticeable effects at doses as low as 20 micrograms and is sometimes taken in much smaller amounts for microdosing. Yet no fatal human overdoses have been documented. LSD is mainly used recreationally or for spiritual purposes. LSD can cause mystical experiences. LSD exerts its effects primarily through high-affinity binding to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
