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Hemivagina
Vaginal anomalies are abnormal structures that are formed (or not formed) during the prenatal development of the female reproductive system and are rare congenital defects that result in an abnormal or absent vagina. When present, they are often found with uterine, skeletal and urinary abnormalities. This is because these structures, like the vagina, are most susceptible to disruption during crucial times of organ-genesis. Many of these defects are classified under the broader term Müllerian duct anomalies. Müllerian duct anomalies are caused by a disturbance during the embryonic time of genitourinary development. The other isolated incidents of vaginal anomalies can occur with no apparent cause. Oftentimes vaginal anomalies are part of a cluster of defects or syndromes. In addition, inheritance can play a part as can prenatal exposure to some teratogens.The inheritance patterns of some vaginal anomalies can be autosomal dominant, autosomal recessive, and X-linked disorders. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OHVIRA
Herlyn–Werner–Wunderlich syndrome, also known as OHVIRA (obstructed hemivagina and ipsilateral renal anomaly) is an extremely rare syndrome characterized by a congenital birth defect of the lower abdominal and pelvic organs. It is a type of abnormality of the Paramesonephric duct, Müllerian ducts. In most cases, OHVIRA presents as a Uterus didelphys, double uterus–either bicorunate or didelphys– with unilateral obstructed (or blind) Vaginal anomalies, hemivagina and ipsilateral renal agenesis (or renal anomalies). It can also affect the urethra, urethral sphincter, ureters, bladder and spleen Although the true incidence is unknown, it has been reported to be between 0.1% and 3%. Development During gestation, the Paramesonephric duct, Müllerian ducts fuse laterally with each other and vertically with the urogenital sinus. Incomplete lateral fusion of the upper Müllerian duct segments causes a bicornuate uterus, whereas complete lack of lateral fusion can lead to Uterus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
