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Dihydrobenzofuran
Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings. This colourless liquid is a component of coal tar. Benzofuran is the structural nucleus (parent compound) of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Production Benzofuran is extracted from coal tar. It is also obtained by dehydrogenation of 2-ethylphenol. Laboratory methods Benzofurans can be prepared by various methods in the laboratory. Notable examples include: *''O''-alkylation of salicylaldehyde with chloroacetic acid followed by dehydration reaction, dehydration (cyclication) of the resulting ether and decarboxylation. *Perkin rearrangement, where a coumarin is reacted with a hydroxide: : *Diels–Alder reaction of Nitroalkene, nitro vinyl furans with various dienophiles: : *Isomerization, Cycloisomerization of alkyne Arene substitution pattern, ortho-substituted phenols: : Related compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psoralen
Psoralen (also called psoralene) is the parent compound in a family of naturally occurring organic compounds known as the linear furanocoumarins. It is structurally related to coumarin by the addition of a fused furan ring, and may be considered as a derivative of umbelliferone. Psoralen occurs naturally in the seeds of ''Psoralea corylifolia'', as well as in the common fig, celery, parsley, Zanthoxylum, West Indian satinwood, and in all citrus fruits. It is widely used in PUVA (psoralen + Ultraviolet#Subtypes, UVA) treatment for psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma; these applications are typically through the use of medications such as Methoxsalen. Many furanocoumarins are extremely toxic to fish, and some are deposited in streams in Indonesia to catch fish. Uses Psoralen is a mutagen, and is used for this purpose in molecular biology research. Psoralen Intercalation (biochemistry), intercalates into DNA and on exposure to ultraviolet (UVA) radiation can f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
