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Acral Fibromyxoma
A superficial acral fibromyxoma is a type of myxoma and is a rare cutaneous condition characterized by a mesenchymal neoplasm that typically occurs on the digits of middle-aged adults. Signs and symptoms Superficial acral fibromyxoma impacts the palm, heel, and ankle in addition to the acral regions, with a clear preference for the periungual and subungual regions of the fingers and toes. It begins as a slow-growing, solitary nodule limited to the dermis and subcutaneous tissue, and it is typically painless. They range in size from 0.6-5 cm. Fifty percent of the cases involve the nails, exhibiting either onycholysis or hyperkeratosis. Causes Although a precise cause has not been identified, history of trauma is uncommon and has been documented. Diagnosis A histologic examination reveals stellate and spindled fibroblast-like cells proliferating moderately within a myxoid and/or collagenous matrix with prominent microvasculature. There may be a hyperkeratotic overlaying epide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermatology
Dermatology is the branch of medicine dealing with the Human skin, skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A List of dermatologists, dermatologist is a specialist medical doctor who manages diseases related to skin. Etymology Attested in English in 1819, the word "dermatology" derives from the Ancient Greek, Greek δέρματος (''dermatos''), genitive of δέρμα (''derma''), "skin" (itself from δέρω ''dero'', "to flay") and -λογία ''wikt:-logia, -logia''. Neo-Latin ''dermatologia'' was coined in 1630, an anatomical term with various French and German uses attested from the 1730s. History In 1708, the first great school of dermatology became a reality at the famous Hôpital Saint-Louis in Paris, and the first textbooks (Willan's, 1798–1808) and atlases (Jean-Louis-Marc Alibert, Alibert's, 1806–1816) appeared in print around the same time.Freedber ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vimentin
Vimentin is a structural protein that in humans is encoded by the ''VIM'' gene. Its name comes from the Latin ''vimentum'' which refers to an array of flexible rods. Vimentin is a Intermediate filament#Type III, type III intermediate filament (IF) protein that is expressed in mesenchymal cells. Intermediate filament, IF proteins are found in all Animal, animal cells as well as bacteria. Intermediate filaments, along with tubulin-based microtubules and actin-based microfilaments, comprise the cytoskeleton. All IF proteins are expressed in a highly developmentally-regulated fashion; vimentin is the major cytoskeletal component of mesenchymal cells. Because of this, vimentin is often used as a marker of mesenchymally-derived cells or cells undergoing an Epithelial-mesenchymal transition, epithelial-to-mesenchymal transition (EMT) during both normal development and Metastasis, metastatic progression. Structure The assembly of the fibrous vimentin filament that forms the cytosk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cutaneous Myxoma
A cutaneous myxoma, or superficial angiomyxoma, consists of a multilobulated myxoid mass containing stellate or spindled fibroblasts with pools of mucin forming cleft-like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate. Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100. Clinically, it may present as solitary or multiple flesh-colored nodules on the face, trunk, or extremities. It may occur as part of the Carney complex, and is sometimes the first sign. Local recurrence is common. Cutaneous myxoma is diagnosed based on histopathological features. The differential diagnosis for cutaneous myxoma include alopecia areata, verrucous hamartoma, cyst, fibroma, glioma, hemangioma, lipoma, scar, and nevus sebaceous. Treatment involves complete surgical excision. Signs and symptoms Cutaneous myxoma appears as a little, slowly expanding dermal or subcutaneous lump that typ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrous Histiocytoma
Fiber (spelled fibre in British English; from ) is a natural or artificial substance that is significantly longer than it is wide. Fibers are often used in the manufacture of other materials. The strongest engineering materials often incorporate fibers, for example carbon fiber and ultra-high-molecular-weight polyethylene. Synthetic fibers can often be produced very cheaply and in large amounts compared to natural fibers, but for clothing natural fibers have some benefits, such as comfort, over their synthetic counterparts. Natural fibers Natural fibers develop or occur in the fiber shape, and include those produced by plants, animals, and geological processes. They can be classified according to their origin: * Vegetable fibers are generally based on arrangements of cellulose, often with lignin: examples include cotton, hemp, jute, flax, abaca, piña, ramie, sisal, bagasse, and banana. Plant fibers are employed in the manufacture of paper and textile (cloth), and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glomus Tumor
:''Glomus tumor was also the name formerly (and incorrectly) used for a tumor now called a paraganglioma.'' A glomus tumor (also known as a "solitary glomus tumor") is a rare neoplasm arising from the glomus body and mainly found under the nail, on the fingertip or in the foot.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . They account for less than 2% of all soft tissue tumors. The majority of glomus tumors are benign, but they can also show malignant features. Glomus tumors were first described by Hoyer in 1877 while the first complete clinical description was given by Masson in 1924. Histologically, glomus tumors are made up of an afferent arteriole, anastomotic vessel, and collecting venule. Glomus tumors are modified smooth muscle cells that control the thermoregulatory function of dermal glomus bodies. As stated above, these lesions should not be confused with paragangliomas, which were formerly also called glomus tu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroma Of Tendon Sheath
Fibroma of tendon sheath is a benign tumor that presents as a small subcutaneous nodule that slowly increases in size. This is a notably uncommon condition. According to case report literature, the tumors often have a multinodular growth pattern, with individual nodules being composed of bland, slender, spindle-shaped cells (myofibroblasts) in a dense, fibrous matrix.” A common microscopic finding is the presence of elongated, slit-like blood vessels. The lesions nearly always arise in the distal portions of the extremities. They often occur on the fingers, hands, toes, or feet. Although they are benign, they may recur after surgical excision in up to 40% of people. Although they may be regarded as a tumor of the skin, the lesions arise from tendons and aponeuroses in superficial sites, and are therefore properly classified in the category of soft-tissue tumor. The World Health Organization in 2020 reclassified these tumors as a specific, benign tumor type in a broad category of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermatofibrosarcoma Protuberans
Dermatofibrosarcoma protuberans (DFSP) is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). Estimates of the overall occurrence of DFSP in the United States are 0.8 to 4.5 cases per million persons per year. In the United States, DFSP accounts for between 1 and 6 percent of all soft-tissue sarcomas and 18 percent of all cutaneous soft-tissue sarcomas. In the Surveillance, Epidemiology, and End Results, Surveillance, Epidemiology and End Results (SEER) tumor registry from 1992 through 2004, DFSP was second only to Kaposi's sarcoma, Kaposi sarcoma. Presentation Dermatofibrosarcoma protuberans begins as a minor firm area of skin most commonly about to 1 to 5 cm in diameter. It can resemble a bruise, birthmark, or pimple. It is a slow-growing tumor and is usually found on the torso but can occur anywhere on the body. About 90% of DFSPs are low-grade sarcomas. About 10% are mix ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mucinosis
Mucinoses are a group of cutaneous diseases caused by fibroblasts producing abnormally large amounts of acid mucopolysaccharides (i.e. mucin), usually hyaluronic acid. Cutaneous mucinosis is a group of conditions involving an accumulation of mucin or glycosaminoglycan in the skin and its annexes. It is described in some connective tissue diseases but never in association with mixed connective tissue disease. See also * Skin lesion * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ... References External links Hyaluronic Acid Mucinoses {{Cutaneous-condition-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurofibroma
A neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors (solitary neurofibroma, solitary nerve sheath tumor or sporadic neurofibroma), while the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability. Neurofibromas arise from nonmyelinating-type Schwann cells that exhibit biallelic inactivation of the ''NF1'' gene that codes for the protein neurofibromin. This protein is responsible for regulating the RAS-mediated cell growth signaling pathway. In contrast to schwannomas, another type of tumor arising from Schwann cells, neurofibromas incorporate many additional types of cells and structural elements in addition to Schwann cells, making it difficult to identify and understand all the mechanisms through which they originate and develop. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Superficial Angiomyxoma
A cutaneous myxoma, or superficial angiomyxoma, consists of a multilobulated myxoid mass containing stellate or spindled fibroblasts with pools of mucin forming cleft-like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate. Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100. Clinically, it may present as solitary or multiple flesh-colored nodules on the face, trunk, or extremities. It may occur as part of the Carney complex, and is sometimes the first sign. Local recurrence is common. Cutaneous myxoma is diagnosed based on histopathological features. The differential diagnosis for cutaneous myxoma include alopecia areata, verrucous hamartoma, cyst, fibroma, glioma, hemangioma, lipoma, scar, and nevus sebaceous. Treatment involves complete surgical excision. Signs and symptoms Cutaneous myxoma appears as a little, slowly expanding dermal or subcutaneous lump that typi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acquired Digital Fibrokeratoma
''Acquired'' is a podcast by Ben Gilbert and David Rosenthal about business history and strategy. As of 2024, the podcast has more than 600,000 monthly listeners. History Gilbert and Rosenthal worked together at Madrona Venture Group and initially had an idea for making a podcast about company acquisitions that became pivotal to the success of the acquiring company. The first episode discussed Pixar Pixar (), doing business as Pixar Animation Studios, is an American animation studio based in Emeryville, California, known for its critically and commercially successful computer-animated feature films. Pixar is a subsidiary of Walt Disney ... and was published in 2015. Over time, the show expanded beyond the acquisition topic to cover business history more generally. References External links * 2015 podcast debuts Audio podcasts Business and finance podcasts {{Podcasting-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroma
Fibromas are benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term "fibroblastic" or "fibromatous" is used to describe tumors of the fibrous connective tissue. When the term ''fibroma'' is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors. Types Hard fibroma The hard fibroma (fibroma durum) consists of many fibres and few cells, e.g. in skin it is called dermatofibroma (fibroma simplex or nodulus cutaneous). A special form is the keloid, which derives from hyperplastic growth of scars. Soft fibroma The soft fibroma (fibroma molle) or fibroma with a shaft ( acrochordon, skin tag, fibroma pendulans) consist of many loosely connected cells and less fibroid tissue. It mostly appears at the neck, armpits or groin. The photo shows a soft fibroma of the eyelid. Other types of fibroma The fibroma cavernosum or angiofibroma, consist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
