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Zymostenol
Zymostenol is an intermediate compound in the biosynthesis of cholesterol and other sterols. It is formed during the conversion of lanosterol to cholesterol, a critical metabolic pathway in animals, fungi, and some protozoa. Biosynthesis Zymostenol is produced from 14-demethyl lanosterol via the action of sterol Δ8,7-sterol isomerase ( emopamil binding protein, EBP). This step is part of the Bloch pathway of cholesterol biosynthesis, where zymostenol is further converted to zymosterol Zymosterol is an intermediate in cholesterol biosynthesis. Disregarding some intermediate compounds (e.g. 4-4-dimethylzymosterol), lanosterol can be considered a precursor of zymosterol in the cholesterol synthesis pathway. The conversion of zymos ... and then to 7-dehydrocholesterol, a direct precursor to cholesterol. References {{Cholesterol and steroid intermediates Sterols Triterpenes Cyclopropanes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholesterol
Cholesterol is the principal sterol of all higher animals, distributed in body Tissue (biology), tissues, especially the brain and spinal cord, and in Animal fat, animal fats and oils. Cholesterol is biosynthesis, biosynthesized by all animal Cell (biology)#Eukaryotic cells, cells and is an essential structural and cholesterol signaling, signaling component of animal cell membranes. In vertebrates, hepatocyte, hepatic cells typically produce the greatest amounts. In the brain, astrocytes produce cholesterol and transport it to neurons. It is absent among prokaryotes (bacteria and archaea), although there are some exceptions, such as ''Mycoplasma'', which require cholesterol for growth. Cholesterol also serves as a Precursor (chemistry), precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Elevated levels of cholesterol in the blood, especially when bound to low-density lipoprotein (LDL, often referred to as "bad cholesterol"), may increase the risk of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sterol
A sterol is any organic compound with a Skeletal formula, skeleton closely related to Cholestanol, cholestan-3-ol. The simplest sterol is gonan-3-ol, which has a formula of , and is derived from that of gonane by replacement of a hydrogen atom on C3 position by a hydroxyl group. It is therefore an alcohol (chemistry), alcohol of gonane. More generally, any compounds that contain the gonane structure, additional functional groups, and/or modified ring systems derived from gonane are called steroids. Therefore, sterols are a subgroup of the steroids. They occur naturally in most Eukaryote, eukaryotes, including plants, animals, and fungi, and can also be produced by some bacteria (however likely with different functions). The most familiar type of animal sterol is cholesterol, which is vital to the structure of the cell membrane, and functions as a precursor to fat-soluble vitamins and steroid hormones. While technically alcohols, sterols are classified by biochemists as lipids (f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lanosterol
Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast, plant steroids are produced via cycloartenol. In the eyes of vertebrates, lanosterol is a natural constituent, having a role in maintaining health of the lens. Lanosterol is the precursor to cholesterol. Biosynthesis The biosynthesis of lanosterol has been intensively investigated. Elaboration of lanosterol under enzyme catalysis leads to other steroids. 14-Demethylation of lanosterol by CYP51 eventually yields cholesterol. Research as an eye drop supplement As a molecule naturally enriched in the eye lens, lanosterol is a component involved in maintenance of lens clarity. Its proposed mechanism of action is to inhibit the aggregation of crystallin proteins, which contribute to the clouding of vision by forming cataracts. Lanosterol is under research for its potential as a therapeutic additive in eye drops to inhibit the aggregation of crysta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protozoa
Protozoa (: protozoan or protozoon; alternative plural: protozoans) are a polyphyletic group of single-celled eukaryotes, either free-living or parasitic, that feed on organic matter such as other microorganisms or organic debris. Historically, protozoans were regarded as "one-celled animals". When first introduced by Georg Goldfuss, in 1818, the taxon Protozoa was erected as a class within the Animalia, with the word 'protozoa' meaning "first animals", because they often possess animal-like behaviours, such as motility and predation, and lack a cell wall, as found in plants and many algae. This classification remained widespread in the 19th and early 20th century, and even became elevated to a variety of higher ranks, including phylum, subkingdom, kingdom, and then sometimes included within the paraphyletic Protoctista or Protista. By the 1970s, it became usual to require that all taxa be monophyletic (derived from a common ancestor that would also be regarded as protozo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRC Press
The CRC Press, LLC is an American publishing group that specializes in producing technical books. Many of their books relate to engineering, science and mathematics. Their scope also includes books on business, forensics and information technology. CRC Press is now a division of Taylor & Francis, itself a subsidiary of Informa. History The CRC Press was founded as the Chemical Rubber Company (CRC) in 1903 by brothers Arthur, Leo and Emanuel Friedman in Cleveland, Ohio, based on an earlier enterprise by Arthur, who had begun selling rubber laboratory aprons in 1900. The company gradually expanded to include sales of laboratory equipment to chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a graduated scientist trained in the study of chemistry, or an officially enrolled student in the field. Chemists study the composition of ...s. In 1913 the CRC offered a short (116-page) manual called the ''Rubber Handboo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sterol Δ8,7-sterol Isomerase
In enzymology, a cholestenol Δ-isomerase () is an enzyme that catalyzes the chemical reaction :5alpha-cholest-7-en-3beta-ol \rightleftharpoons 5alpha-cholest-8-en-3beta-ol Hence, this enzyme has one substrate, 5alpha-cholest-7-en-3beta-ol, and one product, 5alpha-cholest-8-en-3beta-ol. This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is Delta7-cholestenol Delta7-Delta8-isomerase. This enzyme participates in biosynthesis of steroids A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter memb .... See also * Emopamil binding protein References * EC 5.3.3 Enzymes of unknown structure {{isomerase-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emopamil Binding Protein
Emopamil binding protein is a protein that in humans is encoded by the ''EBP'' gene, located on the X chromosome. The protein is shown to have a high-affinity reception for anti-ischemic drugs, such as Emopamil, resulting in its discovery and given name. EBP has a mass of 27.3 kDa and resembles the σ2-receptor that resides in the endoplasmic reticulum of various tissues as an integral membrane protein. Clinical significance Mutations in ''EBP'' cause Conradi–Hünermann syndrome and impairs cholesterol biosynthesis. Unborn males affected with EBP mutations are not expected to be liveborn, (with up to only 5% male births). Individuals, mostly female, that are liveborn with EBP mutations experience stunted growth, limb reduction and back problems. Later in life, the individual may develop cataracts along with coarse hair and hair loss. Research areas Remyelination and MS The inhibition of EBP promotes oligodendrocyte formation, which may help remyelination and thus limit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bloch Pathway
Bloch is a surname of German origin. Notable people with this surname include: A *Adele Bloch-Bauer (1881–1925), Austrian entrepreneur *Albert Bloch (1882–1961), American painter *Alexandre Bloch (1857–1919), French painter *Alfred Bloch (1877-?), French footballer * Aliza Bloch (born 1957), first female mayor of Bet Shemesh, Israel *André Bloch (composer) (1873–1960), French composer and music educator *André Bloch (mathematician) (1893–1948), French mathematician *Andreas Bloch (1860–1917), Norwegian painter, illustrator and costume designer *Andy Bloch (born 1969), American poker player * Anna Bloch (1868–1953), Danish actress *Armand Bloch (1866–1932), French sculptor *Arthur Bloch (born 1948), American writer, author of ''Murphy's Law'' *Augustyn Bloch (1929–2006), Polish composer and organist *Avraham Yitzchak Bloch (1891–1941), Lithuanian rabbi B *Bernard Bloch (linguist) (1907–1965), American linguist *Bernard Bloch (actor) (born 1949), French acto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zymosterol
Zymosterol is an intermediate in cholesterol biosynthesis. Disregarding some intermediate compounds (e.g. 4-4-dimethylzymosterol), lanosterol can be considered a precursor of zymosterol in the cholesterol synthesis pathway. The conversion of zymosterol into cholesterol happens in the endoplasmic reticulum. Zymosterol accumulates quickly in the plasma membrane coming from the cytosol The cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells ( intracellular fluid (ICF)). It is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondri .... The movement of zymosterol across the cytosol is more than twice as fast as the movement of cholesterol itself. References {{steroid-stub Cholestanes Sterols ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigma Aldrich
Sigma-Aldrich (formally MilliporeSigma) is an American chemical, life science, and biotechnology company owned by the multinational chemical conglomerate Merck Group. Sigma-Aldrich was created in 1975 by the merger of Sigma Chemical Company and Aldrich Chemical Company. It grew through various acquisitions until it had over 9,600 employees and was listed on the Fortune 1000. The company has two United States headquarters, in St. Louis and Burlington, MA and has operations in approximately 40 countries. In 2015, the multinational chemical conglomerate Merck Group acquired Sigma-Aldrich for $17 billion. The company is currently a part of Merck's life science business and in combination with Merck's earlier acquired Millipore Corporation, Millipore, operates as MilliporeSigma. It is headquartered in Burlington, Massachusetts, United States. History Sigma Chemical Company of St. Louis and Aldrich Chemical Company of Milwaukee were both American specialty chemical companies when they ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Chemical Biology
''Nature Chemical Biology'' is a monthly peer-reviewed scientific journal published by Nature Portfolio. It was established in June 2005 by founding Chief Editor Terry L. Sheppard as part of Nature Publishing Group. Sheppard was the Chief Editor of the journal 2004–2022. The current editor-in-chief is Russell Johnson. Aims and scope The publishing focus of ''Nature Chemical Biology'' is a forum for original research and commentary in chemical biology. Published topics encompass concepts and research methods in chemistry, biology, and related disciplines with the result of controlling biological systems at the molecular level. Authors (contributors) are chemical biologists, also chemists involved in interdisciplinary research between chemistry and biology, along with biologists who produce research results in understanding and controlling biological processes at the molecular level. Interdisciplinary research in chemistry and biology is emphasized. The journal's main focus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
