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Zhou Jian
Jian Zhou (; February 24, 1957 – March 9, 1999) was a Chinese virologist and cancer researcher, who with fellow researcher Ian Frazer, invented Gardasil and Cervarix, the vaccines for stimulating human immunological resistance to the cervical cancer-inducing human papilloma virus. Early life and education Zhou was born in 1957 in Hangzhou, Zhejiang, China. He was admitted to Wenzhou Medical College in 1977 and graduated 1982. His wife Xiao-Yi Sun (孙小依) was his classmate at the college. He subsequently earned a master's degree from Zhejiang Medical University, where he pursued his research interest in HPV. He then earned his M.D. at Henan Medical University (now medical school of Zhengzhou University) and worked as a postdoctoral researcher at Beijing Medical University, before moving to the University of Cambridge in 1988 to continue his research in cancer and virus. HPV and Papilloma vaccine Zhou met future research partner Ian Frazer at the University of Cambri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hangzhou
Hangzhou, , Standard Mandarin pronunciation: ; formerly romanized as Hangchow is a sub-provincial city in East China and the capital of Zhejiang province. With a population of 13 million, the municipality comprises ten districts, two counties, and one county-level city in northwestern Zhejiang. It is situated at the head of Hangzhou Bay and the estuary of the Qiantang River. Established as a county seat in 221 BC, Hangzhou later served as the capital of the Wuyue Kingdom (923–997) and the Southern Song dynasty (1138–1276). The city has three UNESCO World Heritage Sites, which are the West Lake Cultural Landscape, the Grand Canal, and the Archaeological Ruins of Liangzhu City. Hangzhou is designated as a sub-provincial city. Hangzhou ranked ninth in GDP among mainland Chinese cities and 14th according to the Global Innovation Index. The city hosts the headquarters of Alibaba Group, Ant Group, DeepSeek, Geely, and NetEase. According to the Nature Index, it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Queensland
The University of Queensland is a Public university, public research university located primarily in Brisbane, the capital city of the Australian state of Queensland. Founded in 1909 by the Queensland parliament, UQ is one of the six sandstone universities, an informal designation of the oldest university in each state. UQ is also a founding member of edX, Australia's leading Group of Eight (Australian universities), Group of Eight and the international research-intensive Association of Pacific Rim Universities. The main #St Lucia campus, St Lucia campus occupies much of the riverside inner suburb of St Lucia, Queensland, St Lucia, southwest of the Brisbane central business district. Other UQ campuses and facilities are located throughout Queensland, the largest of which are the University of Queensland Gatton Campus, Gatton campus and the Herston campus, notably including the University of Queensland Mayne Medical School, Mayne Medical School. UQ's overseas establishments incl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cervical Intraepithelial Neoplasia
Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer. More specifically, CIN refers to the potentially Precancerous condition, precancerous transformation of cells of the cervix. CIN most commonly occurs at the Transformation zone, squamocolumnar junction of the cervix, a transitional area between the Squamous epithelial cell, squamous epithelium of the vagina and the columnar epithelium of the endocervix. It can also occur in vaginal walls and vulvar epithelium. CIN is graded on a 1–3 scale, with 3 being the most abnormal (see classification section below). Human papillomavirus (Human papillomavirus infection, HPV) infection is necessary for the development of CIN, but not all with this infection develop cervical cancer. Many women with HPV infection never develop CIN or cervical cancer. Typically, HPV resolves on its own. However, those with an HPV ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The New England Journal Of Medicine
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. Founded in 1812, the journal is among the most prestigious peer-reviewed medical journals. Its 2023 impact factor was 96.2, ranking it 2nd out of 168 journals in the category "Medicine, General & Internal". History In September 1811, Boston physician John Collins Warren, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cervix
The cervix (: cervices) or cervix uteri is a dynamic fibromuscular sexual organ of the female reproductive system that connects the vagina with the uterine cavity. The human female cervix has been documented anatomically since at least the time of Hippocrates, over 2,000 years ago. The cervix is approximately 4 cm long with a diameter of approximately 3 cm and tends to be described as a cylindrical shape, although the front and back walls of the cervix are contiguous. The size of the cervix changes throughout a woman's life cycle. For example, women in the fertile years of their reproductive cycle tend to have larger cervixes than postmenopausal women; likewise, women who have produced offspring have a larger cervix than those who have not. In relation to the vagina, the part of the cervix that opens to the uterus is called the ''internal os'' and the opening of the cervix in the vagina is called the ''external os''. Between them is a conduit commonly called the cervic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oncovirus
An oncovirus or oncogenic virus is a virus that can cause cancer. This term originated from studies of acutely transforming retroviruses in the 1950–60s, when the term ''oncornaviruses'' was used to denote their RNA virus origin. With the letters ''RNA'' removed, it now refers to any virus with a DNA or RNA genome causing cancer and is synonymous with ''tumor virus'' or ''cancer virus''. The vast majority of human and animal viruses do not cause cancer, probably because of longstanding co-evolution between the virus and its host. Oncoviruses have been important not only in epidemiology, but also in investigations of cell cycle control mechanisms such as the retinoblastoma protein. The World Health Organization's International Agency for Research on Cancer estimated that in 2002, infection caused 17.8% of human cancers, with 11.9% caused by one of seven viruses. A 2020 study of 2,658 samples from 38 different types of cancer found that 16% were associated with a virus. These ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Infection
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus particles (virions) attach to and enter susceptible cells. Examples include the common cold, gastroenteritis, COVID-19, the flu, and rabies. Structural characteristics Basic structural characteristics, such as genome type, virion shape and replication site, generally share the same features among virus species within the same family. * Double-stranded DNA families: three are non-enveloped (''Adenoviridae'', ''Papillomaviridae'' and ''Polyomaviridae'') and two are enveloped (''Herpesviridae'' and ''Poxviridae''). All of the non-enveloped families have icosahedral capsids. * Partly double-stranded DNA viruses: ''Hepadnaviridae''. These viruses are enveloped. * One family of single-stranded DNA viruses infects humans: ''Parvoviridae''. These viruses are non-enveloped. * Positive single-stranded RNA families: three non-enveloped (''Astroviridae'', ''Calicivirid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HPV Vaccine
Human papillomavirus (HPV) vaccines are vaccines intended to provide acquired immunity against infection by certain types of human papillomavirus. The first HPV vaccine became available in 2006. Currently there are six licensed HPV vaccines: three bivalent (protect against two types of HPV), two quadrivalent (against four), and one nonavalent vaccine (against nine) All have excellent safety profiles and are highly efficacious, or have met immunobridging standards. All of them protect against HPV types 16 and 18, which are together responsible for approximately 70% of cervical cancer cases globally. The quadrivalent vaccines provide additional protection against HPV types 6 and 11. The nonavalent provides additional protection against HPV types 31, 33, 45, 52 and 58. It is estimated that HPV vaccines may prevent 70% of cervical cancer, 80% of anal cancer, 60% of vaginal cancer, 40% of vulvar cancer, and show more than 90% effectiveness in preventing HPV-positive orophary ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reader's Digest
''Reader's Digest'' is an American general-interest family magazine, published ten times a year. Formerly based in Chappaqua, New York, it is now headquartered in midtown Manhattan. The magazine was founded in 1922 by DeWitt Wallace and his wife Lila Bell Wallace. For many years, ''Reader's Digest'' was the best-selling consumer magazine in the United States; it lost that distinction in 2009 to '' Better Homes and Gardens''. According to Media Mark Research (2006), ''Reader's Digest'' reached more readers with household incomes of over $100,000 than '' Fortune'', ''The Wall Street Journal'', '' Business Week'', and '' Inc.'' combined. Global editions of ''Reader's Digest'' reach an additional 40 million people in more than 70 countries, via 49 editions in 21 languages. The periodical has a global circulation of 10.5 million, making it the largest paid-circulation magazine in the world. It is also published in Braille, digital, and audio editions, and in a large-type edition ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virus-like Particle
Virus-like particles (VLPs) are molecules that closely resemble viruses, but are non-infectious because they contain no viral genetic material. They can be naturally occurring or synthesized through the individual expression of viral structural proteins, which can then self assemble into the virus-like structure. Combinations of structural capsid proteins from different viruses can be used to create recombinant VLPs. Both in-vivo assembly (i.e., assembly inside E. coli bacteria via recombinant co-expression of multiple proteins) and in-vitro assembly (i.e., protein self-assembly in a reaction vessel using stoichiometric quantities of previously purified proteins) have been successfully shown to form virus-like particles. VLPs derived from the Hepatitis B virus (HBV) and composed of the small HBV derived surface antigen (HBsAg) were described in 1968 from patient sera. VLPs have been produced from components of a wide variety of virus families including Parvoviridae (e.g. adeno-associ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
L1 Family
The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the immunoglobulin superfamily ( IgSF CAM). The members of the L1-family in humans are called L1 or L1cam, CHL1 (close homologue of L1), Neurofascin and NRCAM (NgCAM related cell adhesion molecule). L1 family members are found on neurons, especially on their axons. Sometimes they are found on glia, such as Schwann cells, radial glia and Bergmann glia cells and, as such, are important for neural cell migration during development. L1 family members are expressed throughout the vertebrate and invertebrate kingdoms. L1 family members are able to bind to a number of other proteins. As cell adhesion molecules, they often bind "homophilically" to themselves; for example L1 on one cell binding to L1 on an adjacent cell. L1 family members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many cytoplasmic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
