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Yunnanxane
Yunnanxane is a bioactive taxane diterpenoid first isolated from ''Taxus wallichiana''. Yunnanxane was later isolated from cell cultures of ''Taxus cuspidata'' and ''Taxus chinensis''. Four homologous esters of yunnanxane have also been isolated from ''Taxus''. Yunnanxane is reported to have anticancer activity ''in vitro''. See also * Taxusin Taxusin is a taxane isolate derived from ''Taxus wallichiana''. Taxusin can be used to synthesize taxadiene Taxadiene (taxa-4,11-diene) is a diterpene. Taxadiene is the first committed intermediate in the synthesis of taxol. Six hydroxylation r ... * Hongdoushans References Acetate esters Taxanes Vinylidene compounds {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxusin
Taxusin is a taxane isolate derived from ''Taxus wallichiana''. Taxusin can be used to synthesize taxadiene Taxadiene (taxa-4,11-diene) is a diterpene. Taxadiene is the first committed intermediate in the synthesis of taxol. Six hydroxylation reactions, and a few others, are needed to convert taxadiene to baccatin III. Enzymatically, taxadiene is pro ... -diol and -triol derivatives via deoxygenation. See also * Taxoid 7beta-hydroxylase * Yunnanxane * Hongdoushans References Taxanes Acetate esters Vinylidene compounds {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxane
Taxanes are a class of diterpenes. They were originally identified from plants of the genus ''Taxus'' (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer. Taxanes present difficulties in Pharmaceutical formulation, formulation as medicines because they are poorly soluble in water. Production As their name suggests, taxanes were first derived from natural sources, but some have been semisynthesis, semisynthesized. Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of ''Corylus avellana'' (the common hazel plant) has been reported. Mechanism of action The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubule ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxus Wallichiana
''Taxus wallichiana'', the Himalayan yew, is a species of yew, native to the Himalaya and parts of south-east Asia. The species has a variety of uses in traditional medicine. It is currently classified as endangered by the IUCN. Distribution and habitat The species favours a reasonably wide range of habitats, growing in montane, temperate, warm temperate, and tropical submontane to high montane forests which may be deciduous, evergreen, or of mixed character. In forests, it tends to present as a low canopy tree; in open situations it usually forms a large, broadly spreading shrub. Elevation ranges from 900 m to 3,700 m. Growth It is a medium-sized evergreen coniferous tree growing to 10 m tall, similar to ''Taxus baccata'' and sometimes treated as a subspecies of it. The shoots are green at first, becoming brown after three or four years. The leaves are thin, flat, slightly falcate (sickle-shaped), 1.5–2.7 cm long and 2 mm broad, with a softly mucronate apex; the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxus Cuspidata
''Taxus cuspidata'', the Japanese yew or spreading yew, is a member of the genus ''Taxus'', native to Japan, Korea, northeast China and the extreme southeast of Russia. It is an evergreen tree or large shrub growing to 10–18 m tall, with a trunk up to 60 cm diameter. The leaves are lanceolate, flat, dark green, 1–3 cm long and 2–3 mm broad, arranged spirally on the stem, but with the leaf bases twisted to align the leaves in two flattish rows either side of the stem except on erect leading shoots where the spiral arrangement is more obvious. The seed cones are highly modified, each cone containing a single seed 4–8 mm long partly surrounded by a modified scale which develops into a soft, bright red berry-like structure called an aril, 8–12 mm long and wide and open at the end. The arils are mature 6–9 months after pollination. Individual trees from Sikhote-Alin are known to have been 1,000 years old. Uses It is widely grown in eastern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxus Chinensis
''Taxus chinensis'' is a species of yew. It is commonly called the Chinese yew, though this term also refers to '' Taxus celebica'' or ''Taxus sumatrana''. This plant is used to produce medicines for cancer treatment, including Paclitaxel and Taxifolin (found in ''Taxus chinensis var. mairei)''. It can also be used in many other ways and is protected in various ways under Chinese and international law. References External links Taxus chinensis / Chinese yewat the American Conifer Society The American Conifer Society was founded in 1983 to help educate the public about conifer Conifers are a group of conifer cone, cone-bearing Spermatophyte, seed plants, a subset of gymnosperms. Scientifically, they make up the phylum, divisi ... chinensis Trees of China Least concern plants Plants used in bonsai Plants described in 1903 {{Conifer-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hongdoushans
Taxanes are a class of diterpenes. They were originally identified from plants of the genus ''Taxus'' (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer. Taxanes present difficulties in formulation as medicines because they are poorly soluble in water. Production As their name suggests, taxanes were first derived from natural sources, but some have been semisynthesized. Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of ''Corylus avellana'' (the common hazel plant) has been reported. Mechanism of action The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and tax ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetate Esters
An acetate is a salt formed by the combination of acetic acid with a base (e.g. alkaline, earthy, metallic, nonmetallic or radical base). "Acetate" also describes the conjugate base or ion (specifically, the negatively charged ion called an anion) typically found in aqueous solution and written with the chemical formula . The neutral molecules formed by the combination of the acetate ion and a ''positive'' ion (called a cation) are also commonly called "acetates" (hence, ''acetate of lead'', ''acetate of aluminum'', etc.). The simplest of these is hydrogen acetate (called acetic acid) with corresponding salts, esters, and the polyatomic anion , or . Most of the approximately 5 billion kilograms of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In nature, acetate is the most common building block for biosynthesis. Nomenclature and common formula When part of a salt, the formula of the acetate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taxanes
Taxanes are a class of diterpenes. They were originally identified from plants of the genus ''Taxus'' (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer. Taxanes present difficulties in formulation as medicines because they are poorly soluble in water. Production As their name suggests, taxanes were first derived from natural sources, but some have been semisynthesized. Paclitaxel was originally derived from the Pacific yew tree. Taxanes are difficult to synthesize because of their numerous chiral centres—taxol has 11 of these. Recently, the presence of taxanes in the shells and leaves of ''Corylus avellana'' (the common hazel plant) has been reported. Mechanism of action The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
