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Yoshito Kishi
was a Japanese chemist who was the Morris Loeb Professor of Chemistry at Harvard University. He was known for his contributions to the sciences of organic synthesis and total synthesis. Early life and education Kishi was born in Nagoya, Japan and attended Nagoya University, where he obtained both his BS and PhD degrees. He was a postdoctoral research fellow at Harvard University where he worked with Robert Burns Woodward. From 1966 through 1974, he was a professor of chemistry at Nagoya University. Since 1974, Kishi had been a professor of chemistry at Harvard University. Kishi's research has focused on the total synthesis of complex natural products. The accomplishments of his research group include the total syntheses of palytoxin, mycolactones, halichondrins, saxitoxin, tetrodotoxin, geldanamycin, batrachotoxin and many others. Kishi has also contributed to the development of new chemical reactions including the Nozaki–Hiyama–Kishi reaction. Recognition *1999 Imp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nagoya University
, abbreviated to or NU, is a Japanese national research university located in Chikusa-ku, Nagoya. It was established in 1939 as the last of the nine Imperial Universities in the then Empire of Japan, and is now a Designated National University. The university is the birthplace of the Sakata School of physics and the Hirata School of chemistry. As of 2021, seven Nobel Prize winners have been associated with Nagoya University, the third most in Japan and Asia behind Kyoto University and the University of Tokyo. History Nagoya Imperial University was established as the last of the Imperial Universities in 1939 and was later renamed Nagoya University in 1947. Although relatively new as a university, it can trace its roots back to a Temporary Medical School/Public Hospital opened in 1871. Renowned for its contributions in physics and chemistry, the university has been the birthplace of notable scientific advancements such as the Sakata model, the PMNS matrix, the Okazak ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nagoya
is the largest city in the Chūbu region of Japan. It is the list of cities in Japan, fourth-most populous city in Japan, with a population of 2.3million in 2020, and the principal city of the Chūkyō metropolitan area, which is the List of metropolitan areas in Japan, third-most populous metropolitan area in Japan with a population of 10.11million. Located on the Pacific Ocean, Pacific coast in central Honshu, it is the capital and most populous city of Aichi Prefecture, with the Port of Nagoya being Japan's largest seaport. In 1610, the warlord Tokugawa Ieyasu, a retainer of Oda Nobunaga, moved the capital of Owari Province from Kiyosu to Nagoya. This period saw the renovation of Nagoya Castle. The arrival of the 20th century brought a convergence of economic factors that fueled rapid growth in Nagoya during the Meiji Restoration, and it became a major industrial hub for Japan. The traditional manufactures of timepieces, bicycles, and sewing machines were followed by the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Crimson
The Harvard Crimson is the nickname of the college sports teams of Harvard College. The school's teams compete in NCAA Division I. As of 2013, there were 42 Division I intercollegiate Varsity team, varsity sports teams for women and men at Harvard, more than at any other NCAA Division I college in the country. Like the other Ivy League colleges, Harvard does not offer athletic scholarships. Athletics at Harvard began in 1780 when the sophomores challenged the freshmen to a wrestling tournament with the losers buying dinner. Since its historic boat race against archrival Yale in 1852, Harvard has been in the forefront of American intercollegiate sports. Its football team conceived the modern version of the game and devised essentials ranging from the first concrete stadium to a scoreboard to uniform numbers to signals. Originally inspired by List of British and Irish varsity matches, varsity matches between University of Oxford, Oxford University and University of Cambridge, Camb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahedron Prize
The Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic and Medicinal Chemistry is awarded annually by Elsevier, the publisher of Tetrahedron Publications. It was established in 1980 and named in honour of the founding co-chairmen of these publications, Professor Sir Robert Robinson and Professor Robert Burns Woodward. The prize consists of a gold medal, a certificate, and a monetary award of US $15,000. Prizewinners Winners of the prize are: * 2024 Eric N. Jacobsen * 2023 Chuan He * 2022 Chi-Huey Wong * 2021 Richard Bruce Silverman * 2020 Dale L. Boger * 2019 Peter G. Schultz * 2018 Stephen L. Buchwald and John Hartwig * 2017 Laura L. Kiessling * 2016 Ben Feringa * 2015 William L. Jorgensen * 2014 Barry Trost and Jirō Tsuji * 2013 Shankar Balasubramanian * 2012 Paul A. Wender * 2011 Manfred T. Reetz * 2010 Satoshi Ōmura * 2009 Steven V. Ley * 2008 Larry E. Overman * 2007 J. Fraser Stoddart * 2006 Hisashi Yamamoto * 2005 Bernd Giese * 2004 Koji ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imperial Prize Of The Japan Academy
The is a prestigious honor conferred to two of the recipients of the Japan Academy Prize (academics), Japan Academy Prize. Overviews It is awarded in two categories: humanities and natural sciences. The Emperor of Japan, Emperor and Empress of Japan, Empress visit the awarding ceremony and present a vase to the awardees. Laureates * 2019 — Makoto Fujita (chemist), Makoto Fujita (109th) * 2018 — , Chikashi Toyoshima (108th) * 2017 — (107th) * 2016 — Kazutoshi Mori (106th) * 2015 — Hideo Hosono * 2014 — Isamu Akasaki * 2013 — , Yoshinori Tokura * 2012 — , Keiichi Namba (Scientist), Keiichi Namba * 2011 — , (101st)Japan Academy 101st 20 June 2011 retrieved 2011-08-15 * 2010 — , Shinya Yamanaka (100th)Japan Academy 91st-100th retrieved 2011-08-15 * 2009 — , (99th) * 2008 — Keiji Morokuma (98th) * 2007 — , Shizuo Akira (97th) * 2006 — Shuh Narumiya (96th) * 2005 — Kazuya Kato (95th) * 2004 — , Takeshi Yasumoto (94th) * 2003 — Mitsuhiro Yanagi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nozaki–Hiyama–Kishi Reaction
The Nozaki–Hiyama–Kishi reaction is a nickel/chromium coupling reaction forming an alcohol from the reaction of an aldehyde with an allyl or vinyl halide. In their original 1977 publication, Tamejiro Hiyama and Hitoshi Nozaki reported on a chromium(II) salt solution prepared by reduction of chromic chloride by lithium aluminium hydride to which was added benzaldehyde and allyl chloride: : Compared to Grignard reactions, this reaction is very selective towards aldehydes with large tolerance towards a range of functional groups such as ketones, esters, amides and nitriles. Enals give exclusively 1,2-addition. Solvents of choice are DMF and DMSO, one solvent requirement is solubility of the chromium salts. Nozaki–Hiyama–Kishi reaction is a useful method for preparing medium-size rings. In 1983 the scope was extended by the same authors to include vinyl halides or triflates and aryl halides. It was observed that the success of the reaction depended on the source of chrom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical & Engineering News
''Chemical & Engineering News'' (''C&EN'') is a weekly news magazine published by the American Chemical Society (ACS), providing professional and technical news and analysis in the fields of chemistry and chemical engineering.C&EN Magazine Website Chemical and Engineering News, October 12, 2009, accessed October 12, 2009 It includes information on recent news and research in these fields, career and employment information, business and industry news, government and policy news, funding in these fields, and special reports. The magazine is available to all members of the American Chemical Society. The ACS also publishes ''C&EN Global Enterprise'' (), an online resource that republishes articles from ''C&EN'' for easier online access to content. History The magazine was established in 1923,[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'' is the peer review, peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' cover the full range of List of academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Batrachotoxin
Batrachotoxin (BTX) is an extremely potent cardiotoxic and neurotoxic steroidal alkaloid found in certain species of beetles, birds, and frogs. The name is from the Greek word . Structurally-related chemical compounds are often referred to collectively as batrachotoxins. In certain frogs, this alkaloid is present mostly on the skin. Such frogs are among those used for poisoning darts. Batrachotoxin binds to and irreversibly opens the sodium channels of nerve cells and prevents them from closing, resulting in paralysis and death. No antidote is known. History Batrachotoxin was discovered by Fritz Märki and Bernhard Witkop, at the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. Märki and Witkop separated the potent toxic alkaloids fraction from '' Phyllobates bicolor'' and determined its chemical properties in 1963. They isolated four major toxic steroidal alkaloids including batrachotoxin, homobatrachotoxin (is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Geldanamycin
Geldanamycin is a 1,4-benzoquinone ansamycin Antitumor agent, antitumor antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. Geldanamycin induces the degradation of proteins that are mutated or overexpressed in tumor cells such as v-Src, Bcr-Abl, p53, and ERBB2. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate such as hepatotoxicity, further, Jilani ''et al.''. reported that geldanamycin induces the apoptosis of erythrocytes under physiological concentrations. These side effects have led to the development of geldanamycin analogues, in particular analogues containing a derivatisation at the 17 position: * 17-AAG * 17-DMAG Biosynthesis Geldanamycin was original ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrodotoxin
Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an Order (biology), order that includes Tetraodontidae, pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered in these fish, it is found in several other animals (e.g., in blue-ringed octopus, blue-ringed octopuses, Taricha, rough-skinned newts, and Naticidae, moon snails). It is also produced by certain infectious or symbiotic bacteria like ''Pseudoalteromonas tetraodonis, Pseudoalteromonas'', ''Pseudomonas'', and ''Vibrio'' as well as other species found in symbiotic relationships with animals and plants. Although it produces thousands of intoxications annually and several deaths, it has shown efficacy for the treatment of cancer-related pain in phase II and III clinical trials. Tetrodotoxin is a sodium channel blocker. It inhibits the firing of action potentials in neurons by binding to the voltage-gated sodiu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Saxitoxin
Saxitoxin (STX) is a potent neurotoxin and the best-known paralytic shellfish toxin. Ingestion of saxitoxin by humans, usually by consumption of shellfish contaminated by toxic algal blooms, is responsible for the illness known as paralytic shellfish poisoning (PSP). The term saxitoxin originates from the genus name of the butter clam ('' Saxidomus'') from which it was first isolated. But the term saxitoxin can also refer to the entire suite of more than 50 structurally related neurotoxins (known collectively as "saxitoxins") produced by protists, algae and cyanobacteria which includes saxitoxin itself (STX), neosaxitoxin (NSTX), gonyautoxins (GTX) and decarbamoylsaxitoxin (dcSTX). Saxitoxin has a large environmental and economic impact, as its presence in bivalve shellfish such as mussels, clams, oysters and scallops frequently leads to bans on commercial and recreational shellfish harvesting in many temperate coastal waters around the world including the Northeastern and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
