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Why Most Published Research Findings Are False
] "Why Most Published Research Findings Are False" is a 2005 essay written by John Ioannidis, a professor at the Stanford School of Medicine, and published in '' PLOS Medicine''. It is considered foundational to the field of metascience. In the paper, Ioannidis argued that a large number, if not the majority, of published medical research papers contain results that cannot be replicated. In simple terms, the essay states that scientists use hypothesis testing to determine whether scientific discoveries are significant. Statistical significance is formalized in terms of probability, with its ''p-''value measure being reported in the scientific literature as a screening mechanism. Ioannidis posited assumptions about the way people perform and report these tests; then he constructed a statistical model which indicates that most published findings are likely false positive results. While the general arguments in the paper recommending reforms in scientific research methodology wer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ioannidis (2005) Why Most Published Research Findings Are False
Ioannidis or Ioannides () is a Greek language, Greek surname. The female version of the name is Ioannidou or Ioannides. ''Ioannidis'' or ''Ioannides'' is a patronymic surname which literally means "the son of Ioannis (Yiannis)", thus making it equivalent to English Johnson (surname), Johnson. Notable people with surname Ioannidis or Ioannides include: Men * Alkinoos Ioannidis (born 1969), Cypriot composer and singer * Andreas Ioannides (footballer) (born 1975), Cypriot football player * Dimitrios Ioannides (1923–2010), military officer involved in the Greek military junta of 1967–1974 * Evgenios Ioannidis (born 2001), Greek chess player * Fotis Ioannidis (born 2000), Greek footballer * Georgios Ioannidis (born 1988), Greek footballer * Giannis Ioannidis (1945–2023), former basketball coach and politician * John Ioannidis (born 1965), medical researcher * Matt Ioannidis (born 1994), American football player * Nikolaos Ioannidis (born 1994), Greek footballer * Paul Ioannidis (1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bias (statistics)
In the field of statistics, bias is a systematic tendency in which the methods used to gather data and estimate a sample statistic present an inaccurate, skewed or distorted ('' biased'') depiction of reality. Statistical bias exists in numerous stages of the data collection and analysis process, including: the source of the data, the methods used to collect the data, the estimator chosen, and the methods used to analyze the data. Data analysts can take various measures at each stage of the process to reduce the impact of statistical bias in their work. Understanding the source of statistical bias can help to assess whether the observed results are close to actuality. Issues of statistical bias has been argued to be closely linked to issues of statistical validity. Statistical bias can have significant real world implications as data is used to inform decision making across a wide variety of processes in society. Data is used to inform lawmaking, industry regulation, corp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academic Journal Articles
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of tertiary education. The name traces back to Plato's school of philosophy, founded approximately 386 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and skill, north of Athens, Greece. The Royal Spanish Academy defines academy as scientific, literary or artistic society established with public authority and as a teaching establishment, public or private, of a professional, artistic, technical or simply practical nature. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, '' Akademos''. Outside the city walls of Athens, the gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2005 Essays
5 (five) is a number, numeral and digit. It is the natural number, and cardinal number, following 4 and preceding 6, and is a prime number. Humans, and many other animals, have 5 digits on their limbs. Mathematics 5 is a Fermat prime, a Mersenne prime exponent, as well as a Fibonacci number. 5 is the first congruent number, as well as the length of the hypotenuse of the smallest integer-sided right triangle, making part of the smallest Pythagorean triple ( 3, 4, 5). 5 is the first safe prime and the first good prime. 11 forms the first pair of sexy primes with 5. 5 is the second Fermat prime, of a total of five known Fermat primes. 5 is also the first of three known Wilson primes (5, 13, 563). Geometry A shape with five sides is called a pentagon. The pentagon is the first regular polygon that does not tile the plane with copies of itself. It is the largest face any of the five regular three-dimensional regular Platonic solid can have. A conic is determ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Data Sharing
Data sharing is the practice of making data used for scholarly research available to other investigators. Many funding agencies, institutions, and publication venues have policies regarding data sharing because transparency and openness are considered by many to be part of the scientific method. A number of funding agencies and science journals require authors of peer-reviewed papers to share any supplemental information (raw data, statistical methods or source code) necessary to understand, develop or reproduce published research. A great deal of scientific research is not subject to data sharing requirements, and many of these policies have liberal exceptions. In the absence of any binding requirement, data sharing is at the discretion of the scientists themselves. In addition, in certain situations governments and institutions prohibit or severely limit data sharing to protect proprietary interests, national security, and subject/patient/victim confidentiality. Data sharing may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication (statistics)
In engineering, science, and statistics, replication is the process of repeating a study or experiment under the same or similar conditions. It is a crucial step to test the original claim and confirm or reject the accuracy of results as well as for identifying and correcting the flaws in the original experiment. ASTM, in standard E1847, defines replication as "... the repetition of the set of all the treatment combinations to be compared in an experiment. Each of the repetitions is called a ''replicate''." For a full factorial design, replicates are multiple experimental runs with the same factor levels. You can replicate combinations of factor levels, groups of factor level combinations, or even entire designs. For instance, consider a scenario with three factors, each having two levels, and an experiment that tests every possible combination of these levels (a full factorial design). One complete replication of this design would comprise 8 runs (2^3). The design can be executed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cherry Picking
Cherry picking, suppressing evidence, or the fallacy of incomplete evidence is the act of pointing to individual cases or data that seem to confirm a particular position while ignoring a significant portion of related and similar cases or data that may contradict that position. Cherry picking may be committed intentionally or unintentionally. The term is based on the perceived process of harvesting fruit, such as cherries. The picker would be expected to select only the ripest and healthiest fruits. An observer who sees only the selected fruit may thus wrongly conclude that most, or even all, of the tree's fruit is in a likewise good condition. This can also give a false impression of the quality of the fruit (since it is only a sample and is not a representative sample). A concept sometimes confused with cherry picking is the idea of gathering only the fruit that is easy to harvest, while ignoring other fruit that is higher up on the tree and thus more difficult to obtain (see ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Preregistration (science)
Preregistration is the practice of registering the hypotheses, methods, or analyses of a scientific study before it is conducted. Clinical trial registration is similar, although it may not require the registration of a study's analysis protocol. Finally, registered reports include the peer review and in principle acceptance of a study protocol prior to data collection. Preregistration has the goal to transparently evaluate the severity of hypothesis tests,, and can have a number of secondary goals (which can also be achieved without preregistering ), including (a) facilitating and documenting research plans, (b) identifying and reducing questionable research practices and researcher biases, (c) distinguishing between confirmatory and exploratory analyses, and, in the case of Registered Reports, (d) facilitating results-blind peer review, and (e) reducing publication bias. A number of research practices such as p-hacking, publication bias, data dredging, inappropriate forms of po ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeffrey T
Jeffrey may refer to: * Jeffrey (name), including a list of people with the name *Jeffrey's, Newfoundland and Labrador, Canada *Jeffrey City, Wyoming, United States *Jeffrey Street, Sydney, Australia * Jeffreys Bay, Western Cape, South Africa Art and entertainment * ''Jeffrey'' (play), a 1992 off-Broadway play by Paul Rudnick * ''Jeffrey'' (1995 film), a 1995 film by Paul Rudnick, based on Rudnick's play of the same name * ''Jeffrey'' (2016 film), a 2016 Dominican Republic documentary film * Jeffrey's sketch, a sketch on American TV show ''Saturday Night Live'' *'' Nurse Jeffrey'', a spin-off miniseries from the American medical drama series ''House, MD'' People with the surname * Alexander Jeffrey (1806–1874), Scottish solicitor and historian * Carol Jeffrey (1898–1998), English psychotherapist, writer *Charles Jeffrey (footballer) (died 1915), Scottish footballer *E. C. Jeffrey (1866–1952), Canadian-American botanist *Grant Jeffrey (1948–2012), Canadian writer * He ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Replication Crisis
The replication crisis, also known as the reproducibility or replicability crisis, refers to the growing number of published scientific results that other researchers have been unable to reproduce or verify. Because the reproducibility of empirical results is an essential part of the scientific method, such failures undermine the credibility of theories that build on them and can call into question substantial parts of scientific knowledge. The replication crisis is frequently discussed in relation to psychology and medicine, wherein considerable efforts have been undertaken to reinvestigate the results of classic studies to determine whether they are reliable, and if they turn out not to be, the reasons for the failure. Data strongly indicate that other natural science, natural and social sciences are also affected. The phrase "replication crisis" was coined in the early 2010s as part of a growing awareness of the problem. Considerations of causes and remedies have given rise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Groupthink
Groupthink is a psychological phenomenon that occurs within a group of people in which the desire for harmony or conformity in the group results in an irrational or dysfunctional decision-making outcome. Cohesiveness, or the desire for cohesiveness, in a group may produce a tendency among its members to agree at all costs. This causes the group to minimize conflict and reach a consensus decision without critical evaluation. Groupthink is a construct of social psychology but has an extensive reach and influences literature in the fields of communication studies, political science, management, and organizational theory, as well as important aspects of deviant religious cult behaviour. Overview Groupthink is sometimes stated to occur (more broadly) within natural groups within the community, for example to explain the lifelong different mindsets of those with differing political views (such as "conservatism" and "liberalism" in the U.S. political context or the purported benefits of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conflicts Of Interest In Academic Publishing
Conflicts of interest (COIs) often arise in academic publishing. Such conflicts may cause wrongdoing and make it more likely. Ethical standards in academic publishing exist to avoid and deal with conflicts of interest, and the field continues to develop new standards. Standards vary between journals and are unevenly applied. According to the International Committee of Medical Journal Editors, "[a]uthors have a responsibility to evaluate the integrity, history, practices and reputation of the journals to which they submit manuscripts". Conflicts of interest increase the likelihood of biases arising; they can harm the quality of research and the public good (even if disclosed). Conflicts of interest can involve research sponsors, authors, journals, journal staff, publishers, and peer reviewers. Avoidance, disclosure, and tracking The avoidance of conflicts of interest and the changing of the structure of institutions to make them easier to avoid are frequently advocated for. Some ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
