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Wayne L. Hubbell
Wayne L. Hubbell (born 24 March 1943) is an American biochemist and member of the National Academy of Sciences. He is Professor of Biochemistry and Jules Stein Professor of Ophthalmology at the University of California, Los Angeles. His research focuses on the visual system, and is primarily supported by a grant from the National Eye Institute. Research Dr. Hubbell has studied the relationship between the molecular structure of protein and the conformational changes that control its function. Of particular interest are membrane proteins that behave as "molecular switches", i.e., proteins whose structures are switched to an active state by a physical or chemical signals. An example is light-activated rhodopsin, the visual pigment in photoreceptor cells of the retina. The goal is to elucidate the structure of rhodopsin, the mechanism of the molecular switch, and regulation of this switch by associated proteins, transducin and arrestin. Dr. Hubbell's research also includes str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oregon State University
Oregon State University (OSU) is a Public university, public Land-grant university, land-grant research university in Corvallis, Oregon, United States. OSU offers more than 200 undergraduate degree programs and a variety of graduate and doctoral degrees through all 11 of the university's colleges. It has the seventh-largest engineering college in the nation (2023). Undergraduate enrollment for all colleges combined averages over 32,000 while an additional 5,000 students are engaged in post-graduate coursework through the university. In 2023, over 37,000 students were enrolled at OSU, making it the largest university in the state. Out-of-state students typically make up over one-quarter of the student body. Since its founding, over 272,000 students have graduated from OSU. The university is Carnegie Classification of Institutions of Higher Education, classified among "R1: Doctoral Universities – Very high research activity". Initially chartered as a land-grant university, OS ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arrestin
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered in the late '80s as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden and in the β-adrenergic system by Martin J. Lohse and co-workers. Function In response to a stimulus, GPCRs activate heterotrimeric G proteins. In order to turn off this response, or adapt to a persistent stimulus, active receptors need to be desensitized. The first step in desensitization is phosphorylation of the receptor by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). GRK phosphorylation specifically prepares the activated receptor for arrestin binding. Arrestin binding to the receptor blocks further G protein-mediated signaling and targets receptors for int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Biochemists
File:1st century collage.png, From top left, clockwise: Jesus is crucified by Roman authorities in Judaea (17th century painting). Four different men ( Galba, Otho, Vitellius, and Vespasian) claim the title of Emperor within the span of a year; The Great Fire of Rome (18th-century painting) sees the destruction of two-thirds of the city, precipitating the empire's first persecution against Christians, who are blamed for the disaster; The Roman Colosseum is built and holds its inaugural games; Roman forces besiege Jerusalem during the First Jewish–Roman War (19th-century painting); The Trưng sisters lead a rebellion against the Chinese Han dynasty (anachronistic depiction); Boudica, queen of the British Iceni leads a rebellion against Rome (19th-century statue); Knife-shaped coin of the Xin dynasty., 335px rect 30 30 737 1077 Crucifixion of Jesus rect 767 30 1815 1077 Year of the Four Emperors rect 1846 30 3223 1077 Great Fire of Rome rect 30 1108 1106 2155 Boudican re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christian B
A Christian () is a person who follows or adheres to Christianity, a monotheistic Abrahamic religion based on the life and teachings of Jesus Christ. Christians form the largest religious community in the world. The words ''Christ'' and ''Christian'' derive from the Koine Greek title (), a translation of the Biblical Hebrew term '' mashiach'' () (usually rendered as ''messiah'' in English). While there are diverse interpretations of Christianity which sometimes conflict, they are united in believing that Jesus has a unique significance. The term ''Christian'' used as an adjective is descriptive of anything associated with Christianity or Christian churches, or in a proverbial sense "all that is noble, and good, and Christ-like." According to a 2011 Pew Research Center survey, there were 2.3 billion Christians around the world, up from about 600 million in 1910. Today, about 37% of all Christians live in the Americas, about 26% live in Europe, 24% live in sub-Saharan Africa, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field in the United States. Member of the National Academy of Sciences, Members of the National Academy of Sciences serve ''pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Congress legislated and President Abraham Lincoln signed an Act of Congress (1863) establishing the National Academy of Sciences as an independent, trusted nongovernmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Academy Of Arts And Sciences
The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other Founding Fathers of the United States. It is headquartered in Cambridge, Massachusetts. Membership in the academy is achieved through a nominating petition, review, and election process. The academy's quarterly journal, '' Dædalus'', is published by the MIT Press on behalf of the academy, and has been open-access since January 2021. The academy also conducts multidisciplinary public policy research. Laurie L. Patton has served as President of the Academy since January 2025. History The Academy was established by the Massachusetts legislature on May 4, 1780, charted in order "to cultivate every art and science which may tend to advance the interest, honor, dignity, and happiness of a free, independent, and virtuous people." The sixty-tw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pécs
The University of Pécs ( , PTE; ) is one of the largest higher education institutions in Hungary. The history of the university began in the Middle Ages, when in 1367, at the request of Louis I of Hungary, King Louis I the Great, Pope Urban V granted permission to found the institution. This made it the first university in Hungary and the fourth in Central Europe. The official successor of the university is the :hu:Erzsébet Tudományegyetem, Elisabeth University of Bratislava, Pozsony (Bratislava), founded in 1912. In 1921, after Bratislava became part of Czechoslovakia, the university was moved to Pécs in 1951, the Faculty of Medicine separated and existed as an independent institution, until it merged with the Janus Pannonius University () in 2000, which united the other faculties in Pécs. This is how the current University of Pécs was created. Approximately 22,000 students attend the university at the moment, 4,900 of whom are international students enrolled in English or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysical Society
The Biophysical Society is an international scientific society whose purpose is to lead the development and dissemination of knowledge in biophysics. Founded in 1958, the Society currently consists of over 7,000 members in academia, government, and industry. Although the Society is based in the United States, it is an international organization. Overseas members currently comprise over one third of the total. Origins The Biophysical Society was founded in response to the growth of the field of biophysics after World War Two, as well as concerns that the American Physiological Society had become too large to serve the community of biophysicists. Discussions between prominent biophysicists in 1955 and 1956 led to the planning of the society's first meeting in Columbus, Ohio in 1957, with about 500 attendees. Among the scientists involved in the early effort were Ernest C. Pollard, Samuel Talbot, Otto Schmitt, Kenneth Stewart Cole, W. A. Selle, Max Lauffer, Ralph Stacy, Herm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alfred P
Alfred may refer to: Arts and entertainment *'' Alfred J. Kwak'', Dutch-German-Japanese anime television series * ''Alfred'' (Arne opera), a 1740 masque by Thomas Arne * ''Alfred'' (Dvořák), an 1870 opera by Antonín Dvořák *"Alfred (Interlude)" and "Alfred (Outro)", songs by Eminem from the 2020 album '' Music to Be Murdered By'' Business and organisations * Alfred, a radio station in Shaftesbury, England * Alfred Music, an American music publisher * Alfred University, New York, U.S. * The Alfred Hospital, a hospital in Melbourne, Australia People * Alfred (name) includes a list of people and fictional characters called Alfred * Alfred the Great (848/49 – 899), or Alfred I, a king of the West Saxons and of the Anglo-Saxons Places Antarctica * Mount Alfred (Antarctica) Australia * Alfredtown, New South Wales * County of Alfred, South Australia Canada * Alfred and Plantagenet, Ontario ** Alfred, Ontario, a community in Alfred and Plantagenet * Alfred Island, Nunavu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Paramagnetic Resonance
Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy is a method for studying materials that have unpaired electrons. The basic concepts of EPR are analogous to those of nuclear magnetic resonance (NMR), but the spins excited are those of the electrons instead of the atomic nuclei. EPR spectroscopy is particularly useful for studying metal complexes and organic radicals. EPR was first observed in Kazan State University by Soviet physicist Yevgeny Zavoisky in 1944, and was developed independently at the same time by Brebis Bleaney at the University of Oxford. Theory Origin of an EPR signal Every electron has a magnetic moment and spin quantum number s = \tfrac , with magnetic components m_\mathrm = + \tfrac or m_\mathrm = - \tfrac . In the presence of an external magnetic field with strength B_\mathrm , the electron's magnetic moment aligns itself either antiparallel ( m_\mathrm = - \tfrac ) or parallel ( m_\mathrm = + \tfrac ) to the fie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Site-directed Spin Labeling
Site-directed spin labeling (SDSL) is a technique for investigating the structure and local dynamics of proteins using electron spin resonance. The theory of SDSL is based on the specific reaction of spin labels with amino acids. A spin label's built-in protein structure can be detected by EPR spectroscopy. SDSL is also a useful tool in examinations of the protein folding process. Spin labeling Site-directed spin labeling (SDSL) was pioneered in the laboratory of Dr. W.L. Hubbell. In SDSL, sites for attachment of spin labels are introduced into recombinantly expressed proteins by site-directed mutagenesis. Functional group In organic chemistry, a functional group is any substituent or moiety (chemistry), moiety in a molecule that causes the molecule's characteristic chemical reactions. The same functional group will undergo the same or similar chemical reactions r ...s contained within the spin label determine their specificity. At neutral pH, protein thiol groups speci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
