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Water Intoxication
Water intoxication, also known as water poisoning, hyperhydration, overhydration, or water toxemia, is a potentially fatal disturbance in brain functions that can result when the normal balance of electrolytes in the body is pushed outside safe limits by excessive water intake. Under normal circumstances, accidentally consuming too much water is exceptionally rare. Most deaths related to water intoxication in healthy individuals have resulted either from water-drinking competition, contests, in which individuals attempt to consume large amounts of water, or from long bouts of exercise during which excessive amounts of fluid were consumed. In addition, water cure (torture), water cure, a method of torture in which the victim is forced to consume excessive amounts of water, can cause water intoxication. Water, like any other substance, can be considered a poison when over-consumed in a brief period. Water intoxication mostly occurs when water is being consumed in a high quantity p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston Marathon
The Boston Marathon is an annual marathon race hosted by eight cities and towns in greater Boston in eastern Massachusetts, United States. It is traditionally held on Patriots' Day, the third Monday of April. Begun in 1897, the event was inspired by the success of the first marathon competition in the 1896 Summer Olympics. The Boston Marathon is the world's oldest annual marathon and ranks as one of the world's best-known road racing events. It is one of seven World Marathon Majors. Its course runs from Hopkinton in southern Middlesex County to Copley Square in Boston. The Boston Athletic Association (B.A.A.) has organized this event annually since 1897, including a "virtual alternative" after the 2020 road race was canceled due to the COVID-19 pandemic. The race has been managed by DMSE Sports since 1988. Amateur and professional runners from all over the world compete in the Boston Marathon each year, braving the hilly Massachusetts terrain and varying weather to take ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intracranial Pressure
Intracranial pressure (ICP) is the pressure exerted by fluids such as cerebrospinal fluid (CSF) inside the skull and on the brain tissue. ICP is measured in millimeters of mercury ( mmHg) and at rest, is normally 7–15 mmHg for a supine adult. This equals to 9–20 cmH2O, which is a common scale used in lumbar punctures. The body has various mechanisms by which it keeps the ICP stable, with CSF pressures varying by about 1 mmHg in normal adults through shifts in production and absorption of CSF. Changes in ICP are attributed to volume changes in one or more of the constituents contained in the cranium. CSF pressure has been shown to be influenced by abrupt changes in intrathoracic pressure during coughing (which is induced by contraction of the diaphragm and abdominal wall muscles, the latter of which also increases intra-abdominal pressure), the valsalva maneuver, and communication with the vasculature ( venous and arterial systems). Intracranial hypertension (IH), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osmosis
Osmosis (, ) is the spontaneous net movement or diffusion of solvent molecules through a selectively permeable membrane, selectively-permeable membrane from a region of high water potential (region of lower solute concentration) to a region of low water potential (region of higher solute concentration), in the direction that tends to equalize the solute concentrations on the two sides. It may also be used to describe a physical process in which any solvent moves across a selectively permeable membrane (permeable to the solvent, but not the solute) separating two solutions of different concentrations. Osmosis can be made to do Work (physics), work. Osmotic pressure is defined as the external pressure required to prevent net movement of solvent across the membrane. Osmotic pressure is a colligative properties, colligative property, meaning that the osmotic pressure depends on the molar concentration of the solute but not on its identity. Osmosis is a vital process in biology, bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osmotic Concentration
Osmotic concentration, formerly known as osmolarity, is the measure of solute concentration, defined as the number of osmoles (Osm) of solute per litre (L) of solution (osmol/L or Osm/L). The osmolarity of a solution is usually expressed as Osm/L (pronounced "osmolar"), in the same way that the molarity of a solution is expressed as "M" (pronounced "molar"). Whereas molarity measures the number of moles of solute per unit volume of solution, osmolarity measures the number of particles on dissociation of osmotically active material (''osmoles of solute particles)'' per unit volume of solution. This value allows the measurement of the osmotic pressure of a solution and the determination of how the solvent will diffuse across a semipermeable membrane (osmosis) separating two solutions of different osmotic concentration. Unit The unit of osmotic concentration is the ''osmole''. This is a non- SI unit of measurement that defines the number of moles of solute that contribute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes Insipidus
Diabetes insipidus (DI) is a condition characterized by large amounts of dilute urine and increased thirst. The amount of urine produced can be nearly 20 liters per day. Reduction of fluid has little effect on the concentration of the urine. Complications may include dehydration or seizures. There are four types of DI, each with a different set of causes. # Central DI (CDI), now known as arginine vasopressin deficiency (AVP-D), is due to a lack of vasopressin (antidiuretic hormone) production. This can be due to injury to the hypothalamus or pituitary gland or due to genetics. # Nephrogenic DI (NDI), also known as arginine vasopressin resistance (AVP-R), occurs when the kidneys do not respond properly to vasopressin. # Dipsogenic DI is a result of excessive fluid intake due to damage to the hypothalamic thirst mechanism. It occurs more often in those with certain psychiatric disorders or on certain medications. # Gestational DI occurs only during pregnancy. Diagnosis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxcarbazepine
Oxcarbazepine, sold under the brand name Trileptal among others, is a medication used to treat epilepsy. For epilepsy it is used for both focal seizures and generalized seizures. It has been used both alone and as add-on therapy in people with bipolar disorder who have had no success with other treatments. It is taken Oral administration, by mouth. Common side effects include nausea, vomiting, dizziness, drowsiness, diplopia, double vision and ataxia, trouble with walking. Serious side effects may include anaphylaxis, liver problems, pancreatitis, suicide ideation, and an arrhythmia, abnormal heart beat. While use during pregnancy may harm the baby, use may be less risky than having a seizure. Use is not recommended during breastfeeding. In those with an allergy to carbamazepine there is a 25% risk of problems with oxcarbazepine. How it works is not entirely clear. Oxcarbazepine was patented in 1969 and came into medical use in 1990. It is available as a generic medication. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypernatremia
Hypernatremia, also spelled hypernatraemia, is a high concentration of sodium in the blood. Early symptoms may include a strong feeling of thirst, weakness, nausea, and loss of appetite. Severe symptoms include confusion, muscle twitching, and bleeding in or around the brain. Normal serum sodium levels are 135–145 mmol/L (135–145 mEq/L). Hypernatremia is generally defined as a serum sodium level of more than 145 mmol/L. Severe symptoms typically only occur when levels are above 160 mmol/L. Hypernatremia is typically classified by a person's fluid status into low volume, normal volume, and high volume. Low volume hypernatremia can occur from sweating, vomiting, diarrhea, diuretic medication, or kidney disease. Normal volume hypernatremia can be due to fever, extreme thirst, prolonged increased breath rate, diabetes insipidus, and from lithium among other causes. High volume hypernatremia can be due to hyperaldosteronism, excessive administration of i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tonicity
In chemical biology, tonicity is a measure of the effective osmotic pressure gradient; the water potential of two Solution (chemistry), solutions separated by a Semipermeable membrane, partially-permeable cell Cell membrane, membrane. Tonicity depends on the relative concentration of selective membrane-impermeable solutes across a cell membrane which determine the direction and extent of osmotic flux. It is commonly used when describing the swelling-versus-shrinking response of cell (biology), cells immersed in an external solution. Unlike osmotic pressure, tonicity is influenced only by solutes that cannot cross the membrane, as only these exert an effective osmotic pressure. Solutes able to freely cross the membrane do not affect tonicity because they will always equilibrate with equal concentrations on both sides of the membrane without net solvent movement. It is also a factor affecting imbibition. There are three classifications of tonicity that one solution can have rela ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nasogastric Tube
Nasogastric intubation is a medical process involving the insertion of a plastic tube (nasogastric tube or NG tube) through the nose, down the esophagus, and down into the stomach. Orogastric intubation is a similar process involving the insertion of a plastic tube (orogastric tube) through the mouth. Abraham Louis Levin invented the NG tube. Nasogastric tube is also known as Ryle's tube in Commonwealth countries, after John Alfred Ryle. Uses A nasogastric tube is used for feeding and administering drugs and other oral agents such as activated charcoal. For drugs and for minimal quantities of liquid, a syringe is used for injection into the tube. For continuous feeding, a gravity based system is employed, with the solution placed higher than the patient's stomach. If accrued supervision is required for the feeding, the tube is often connected to an electronic pump which can control and measure the patient's intake and signal any interruption in the feeding. Nasogastric tubes may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Total Parenteral Nutrition
Parenteral nutrition (PN), or intravenous feeding, is the feeding of nutritional products to a person intravenously, bypassing the usual process of eating and digestion. The products are made by pharmaceutical compounding entities or standard pharmaceutical companies. The person receives a nutritional mix according to a formula including glucose, salts, amino acids, lipids and vitamins and dietary minerals. It is called total parenteral nutrition (TPN) or total nutrient admixture (TNA) when no significant nutrition is obtained by other routes, and partial parenteral nutrition (PPN) when nutrition is also partially gastrointestinal tract, enteric. It is called peripheral parenteral nutrition (PPN) when administered through Peripherally inserted central catheter, vein access in a limb rather than through a central venous catheter, central vein as in central venous nutrition (CVN). Medical uses Total wikt:parenteral, parenteral nutrition (TPN) is provided when the Human gastrointesti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychogenic Polydipsia
Primary polydipsia and psychogenic polydipsia are forms of polydipsia characterised by excessive fluid intake in the absence of physiological stimuli to drink. Psychogenic polydipsia caused by psychiatric disordersoftentimes schizophreniais frequently accompanied by the sensation of dry mouth. Some conditions with polydipsia as a symptom are non-psychogenic (e.g., early Type 2 diabetes, primary hyperaldosteronism, and zinc deficiency, and some forms of diabetes insipidus). Primary polydipsia is a diagnosis of exclusion. Signs and symptoms Signs and symptoms of psychogenic polydipsia include: * Excessive thirst and xerostomia, leading to overconsumption of water * Hyponatraemia, causing headache, muscular weakness, twitching, confusion, vomiting, irritability etc., although this is only seen in 20–30% of cases. * Hypervolemia, leading to oedema, hypertension and weight gain (due to the kidneys being unable to filter the excess blood) in extreme episodes * Tonic-clonic seizu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
