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Veterinary Virology
Veterinary virology is the study of viruses in non-human animals. It is an important branch of veterinary medicine. Rhabdoviruses Rhabdoviruses are a diverse family of single stranded, negative sense RNA viruses that infect a wide range of hosts, from plants and insects, to fish and mammals. The ''Rhaboviridae'' family consists of six genera, two of which, cytorhabdoviruses and nucleorhabdoviruses, only infect plants. Novirhabdoviruses infect fish, and vesiculovirus, lyssavirus and ephemerovirus infect mammals, fish and invertebrates. The family includes pathogens such as rabies virus, vesicular stomatitis virus and potato yellow dwarf virus that are of public health, veterinary, and agricultural significance. Foot-and-mouth disease virus Foot-and-mouth disease virus (FMDV) is a member of the Aphthovirus genus in the Picornaviridae family and is the cause of foot-and-mouth disease in pigs, cattle, sheep and goats. It is a non-enveloped, positive strand, RNA virus. FMDV ...
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Bluetongue Virus
Bluetongue virus (BTV) is a dsRNA virus of the genus '' Orbivirus''. The virus causes Bluetongue disease.ICTV''Bluetongue virus'' EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL #35) BTV is relatively fragile and its infectivity is lost in slightly acidic environments. The recently spreading BTV-3 variant (BTV-3/NET2023) has raised concerns due to its fast spread in Europe, and the introduction of this variant could pose new challenges for disease control. In response to this, several countries have implemented vaccination campaigns, but the challenge lies in matching vaccines to the circulating strain. The BTV-3 variant’s genetic stability has been confirmed through sequencing, and vaccines currently in use are expected to be effective against it. References Orbiviruses {{virus-stub ...
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Equine Viral Arteritis
Equine viral arteritis (EVA) is a disease of horses caused by a virus of the species Equine arteritis virus (''Alphaarterivirus equid''), an RNA virus. It is the only species in the genus ''Alphaarterivirus'', and that is the only genus in the ''Equarterivirinae'' subfamily. The virus which causes EVA was first isolated in 1953, but the disease has afflicted equine animals worldwide for centuries. It has been more common in some breeds of horses in the United States, but there is no breed "immunity". In the UK, it is a notifiable disease. There is no known human hazard. Signs The signs shown depend on the horse's age, the strain of the infecting virus, the condition of the horse and the route by which it was infected. Most horses with EVA infection do not show any signs; if a horse does show signs, these can vary greatly in severity. Following infection, the first sign is fever, peaking at , followed by various signs such as lethargy, nasal discharge, "pink eye" (conjunctivitis ...
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Bluetongue Disease
Bluetongue (BT) disease is a noncontagious, arthropod-borne viral disease affecting ruminants, primarily sheep and other domestic or wild ruminants, including cattle, yaks, goats, buffalo, deer, dromedaries, and antelope. It is caused by Bluetongue virus (BTV), a non-enveloped, double-stranded RNA virus belongs to the genus ''Orbivirus'' within the family ''Sedoreoviridae''. The virus is mainly transmitted by biting midges, specifically ''Culicoides'' species (e.g. ''Culicoides imicola'', ''Culicoides oxystoma,'' and '' Culicoides variipennis''). BTV has a widespread geographical distribution, encompassing numerous continents and regions, including Africa, Asia, Australia, Europe, North America, and various tropical and subtropical regions. At present, there are more than 28 recognized serotypes of BTV. Bluetongue outbreaks have had a significant economic impact, with estimated global losses reaching approximately US$3 billion. Clinical signs In sheep, BTV causes an a ...
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Pandemic
A pandemic ( ) is an epidemic of an infectious disease that has a sudden increase in cases and spreads across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. Widespread endemic (epidemiology), endemic diseases with a stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide. Throughout human history, there have been a number of pandemics of diseases such as smallpox. The Black Death, caused by the Plague (disease), Plague, caused the deaths of up to half of the population of Europe in the 14th century. The term ''pandemic'' had not been used then, but was used for later epidemics, including the 1918 Influenza A virus subtype H1N1, H1N1 influenza A pandemic—more commonly known as the Spanish flu—which is the Deadliest pandemics in history, deadliest pandemic in history. The mos ...
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Influenza
Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus: types A, B, C, and D. Aquatic birds are the primary source of influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and influenza C virus (ICV) primarily infect humans, and influenza D virus (IDV) i ...
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Orthomyxoviridae
''Orthomyxoviridae'' () is a family of negative-sense single-stranded RNA virus, negative-sense RNA viruses. It includes nine genus, genera: ''Influenza A virus, Alphainfluenzavirus'', ''Influenza B virus, Betainfluenzavirus'', ''Influenza C virus, Gammainfluenzavirus'', ''Influenza D virus, Deltainfluenzavirus'', ''Isavirus'', ''Mykissvirus'', ''Quaranjavirus'', ''Sardinovirus'', and ''Thogotovirus''. The first four genera contain viruses that cause influenza in birds (see also avian influenza) and mammals, including humans. Isaviruses infect salmon; the thogotoviruses are arboviruses, infecting vertebrates and invertebrates (such as ticks and mosquitoes). The Quaranjaviruses are also arboviruses, infecting vertebrates (birds) and invertebrates (arthropods). The four genera of Influenza virus that infect vertebrates, which are identified by antigenic differences in their nucleoprotein and matrix protein, are as follows: * ''Influenza A virus, Alphainfluenzavirus'' infects huma ...
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Influenza
Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin one to four (typically two) days after exposure to the virus and last for about two to eight days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia from the virus or a subsequent bacterial infection. Other complications include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus: types A, B, C, and D. Aquatic birds are the primary source of influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and influenza C virus (ICV) primarily infect humans, and influenza D virus (IDV) i ...
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Gastroenteritis
Gastroenteritis, also known as infectious diarrhea, is an inflammation of the Human gastrointestinal tract, gastrointestinal tract including the stomach and intestine. Symptoms may include diarrhea, vomiting, and abdominal pain. Fever, lack of energy, and dehydration may also occur. This typically lasts less than two weeks. Although it is not related to influenza, in the U.S it is sometimes called the "stomach flu". Gastroenteritis is usually caused by viruses; however, gut bacteria, parasites, and fungus, fungi can also cause gastroenteritis. In children, rotavirus is the most common cause of severe disease. In adults, norovirus and ''Campylobacter'' are common causes. Eating improperly prepared food, drinking contaminated water or close contact with a person who is infected can #Transmission, spread the disease. Treatment is generally the same with or without a definitive diagnosis, so testing to confirm is usually not needed. For young children in impoverished countries, pre ...
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Vertebrates
Vertebrates () are animals with a vertebral column (backbone or spine), and a cranium, or skull. The vertebral column surrounds and protects the spinal cord, while the cranium protects the brain. The vertebrates make up the subphylum Vertebrata with some 65,000 species, by far the largest ranked grouping in the phylum Chordata. The vertebrates include mammals, birds, amphibians, and various classes of fish and reptiles. The fish include the jawless Agnatha, and the jawed Gnathostomata. The jawed fish include both the Chondrichthyes, cartilaginous fish and the Osteichthyes, bony fish. Bony fish include the Sarcopterygii, lobe-finned fish, which gave rise to the tetrapods, the animals with four limbs. Despite their success, vertebrates still only make up less than five percent of all described animal species. The first vertebrates appeared in the Cambrian explosion some 518 million years ago. Jawed vertebrates evolved in the Ordovician, followed by bony fishes in the Devonian. T ...
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Coronaviridae
''Coronaviridae'' is a family (biology), family of Viral envelope, enveloped, positive-strand RNA viruses which infect fish, amphibians, birds, and mammals. The group includes the subfamilies ''Letovirinae,'' ''Orthocoronavirinae'', and ''Pitovirinae''. The members of the subfamily ''Orthocoronavirinae'' are known as Coronavirus, coronaviruses. The viral genome is 26–32 kilobases in length. The particles are typically decorated with large (~20 nm), club- or petal-shaped surface projections (the "peplomers" or "spikes"), which in electron micrographs of spherical particles create an image reminiscent of the solar corona. Virology The 5' and 3' ends of the genome have a Five-prime cap, cap and poly(A) tract, respectively. The viral envelope, obtained by budding through membranes of the endoplasmic reticulum (ER) or Golgi apparatus, invariably contains two virus-specified glycoprotein species, known as the spike (S) and membrane (M) proteins. The coronavirus spike protein, ...
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Torovirus
''Torovirus'' is a genus of Viral envelope, enveloped, positive-strand RNA viruses in the order ''Nidovirales'' and family ''Tobaniviridae''. They primarily infect vertebrates, especially cattle, pigs, and horses. Diseases associated with this genus include gastroenteritis, which commonly presents in mammals. ''Torovirus'' is the only genus in the Monotypic taxon, monotypic subfamily ''Torovirinae''. The discovery of the first torovirus can be traced back to 1970s. Equine torovirus (EToV) was accidentally found in the rectal sample from a horse who was experiencing severe diarrhea. The 'Breda' bovine torovirus was later found in 1979 while investigation in a dairy farm in Breda. They had several calves experiencing severe diarrhea for months. In 1984, torovirus-like particles were detected with Electron Microscope, electron microscope (EM) technique in the human patients with gastroenteritis. Virology Taxonomy Until recently, the toroviruses were not assigned any family. The ...
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Coronavirus
Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS and COVID-19. In cows and pigs they cause diarrhea, while in mice they cause hepatitis and encephalomyelitis. Coronaviruses constitute the subfamily ''Orthocoronavirinae'', in the family ''Coronaviridae'', order ''Nidovirales'' and realm ''Riboviria''. They are enveloped viruses with a Positive-strand RNA virus, positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry. The genome size of coronaviruses ranges from approximately 26 to 32 kilobases, one of the largest among RNA viruses. They have characteristic club-shaped Spike protein, spikes that project from their surface, which in electron ...
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