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Vertex Pharmaceuticals
Vertex Pharmaceuticals Incorporated is an American biopharmaceutical company based in Boston, Massachusetts. It was one of the first biotech firms to use an explicit strategy of rational drug design rather than combinatorial chemistry. It maintains headquarters in Boston, Massachusetts, and three research facilities, in San Diego, California, and Milton Park, Oxfordshire, England. History Vertex was founded in 1989 by Joshua Boger and Kevin J. Kinsella . to "transform the way serious diseases are treated." The company's beginnings were profiled by Barry Werth in the 1994 book '' The Billion-Dollar Molecule''. His 2014 book, ''The Antidote: Inside the World of New Pharma'', chronicled the company's subsequent development over the next two decades. By 2004, its product pipeline focused on viral infections, inflammatory and autoimmune disorders, and cancer. In 2009, the company had about 1,800 employees, including 1,200 in the Boston area. By 2019 there were about 2,500 empl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Company
A public company is a company whose ownership is organized via shares of share capital, stock which are intended to be freely traded on a stock exchange or in over-the-counter (finance), over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listing (finance), listed company), which facilitates the trade of shares, or not (unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states and so have associations and formal designations, which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation, though a corporation need not be a public company. In the United Kin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
San Diego, California
San Diego ( , ) is a city on the Pacific coast of Southern California, adjacent to the Mexico–United States border. With a population of over 1.4 million, it is the List of United States cities by population, eighth-most populous city in the United States. San Diego is the county seat, seat of San Diego County. It is known for its mild Mediterranean climate, extensive List of beaches in San Diego County, beaches and List of parks in San Diego, parks, long association with the United States Navy, and recent emergence as a wireless, electronics, List of hospitals in San Diego, healthcare, and biotechnology development center. Historically home to the Kumeyaay people, San Diego has been referred to as the ''Birthplace of California'', as it was the first site visited and settled by Europeans on what is now the West Coast of the United States. In 1542, Juan Rodríguez Cabrillo claimed the area for Spain, forming the basis for the settlement of Alta California, 200 years later. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seattle
Seattle ( ) is the most populous city in the U.S. state of Washington and in the Pacific Northwest region of North America. With a population of 780,995 in 2024, it is the 18th-most populous city in the United States. The city is the county seat of King County, the most populous county in Washington. The Seattle metropolitan area's population is 4.02 million, making it the 15th-most populous in the United States. Its growth rate of 21.1% between 2010 and 2020 made it one of the country's fastest-growing large cities. Seattle is situated on an isthmus between Puget Sound, an inlet of the Pacific Ocean, and Lake Washington. It is the northernmost major city in the United States, located about south of the Canadian border. A gateway for trade with East Asia, the Port of Seattle is the fourth-largest port in North America in terms of container handling . The Seattle area has been inhabited by Native Americans (such as the Duwamish, who had at least 17 villages a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myotonic Dystrophy
Myotonic dystrophy (DM) is a type of muscular dystrophy, a group of genetic disorders that cause progressive muscle loss and weakness. In DM, muscles are often myotonia, unable to relax after contraction. Other manifestations may include cataracts, intellectual disability and arrhythmia, heart conduction problems. In men, there may be early balding and infertility. While myotonic dystrophy can occur at any age, onset is typically in the 20s and 30s. Myotonic dystrophy is caused by a genetic mutation in one of two genes. Mutation of the ''Myotonin-protein kinase, DMPK'' gene causes myotonic dystrophy type 1 (DM1). Mutation of ''CNBP'' gene causes type 2 (DM2). DM is typically heredity, inherited, following an autosomal dominant inheritance pattern, and it generally anticipation (genetics), worsens with each generation. A type of DM1 may be apparent at birth. DM2 is generally milder. Diagnosis is confirmed by genetic testing. There is no cure. Treatments may include braces or wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy predominantly affecting boys. The onset of muscle weakness typically begins around age four, with rapid progression. Initially, muscle loss occurs in the thighs and pelvis, extending to the arms, which can lead to difficulties in standing up. By the age of 12, most individuals with Duchenne muscular dystrophy are unable to walk. Affected muscles may appear larger due to an increase in fat content, and scoliosis is common. Some individuals may experience intellectual disability, and females carrying a single copy of the mutated gene may show mild symptoms. Duchenne muscular dystrophy is caused by mutations or deletions in any of the 79 exons encoding the large dystrophin protein, which is essential for maintaining the muscle fibers' cell membrane integrity. The disorder follows an X-linked recessive inheritance pattern, with approximately two-thirds of cases inherited from the mother and one-third res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MarketWatch
''MarketWatch'' is a website that provides financial information, business news, analysis, and stock market data. It is a subsidiary of Dow Jones & Company, a property of News Corp, along with ''The Wall Street Journal'' and '' Barron's.'' History The company was conceived as DBC Online by Data Broadcasting Corporation in the fall of 1995. The marketwatch.com domain name was registered on July 30, 1997. The website launched on October 30, 1997, as a 50/50 joint venture between DBC and CBS News, then run by Larry Kramer and co-founder and chairman, Derek Reisfield. Thom Calandra was its first editor-in-chief. In 1999, the company hired David Callaway and in 2003, Callaway became editor-in-chief. In January 1999, during the dot-com bubble, the company became a public company via an initial public offering. After pricing at $17 per share, the stock traded as high as $130 per share on its first day of trading, giving it a market capitalization of over $1 billion despite o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Code Of Conduct
A code of conduct is a set of rules outlining the social norm, norms, rules, and responsibilities or proper practices of an individual party or an organization. Companies' codes of conduct A company code of conduct is a set of rules which is commonly written for employees of a company, which protects the business and informs the employees of the company's expectations. It is appropriate for even the smallest of companies to create a document containing important information on expectations for employees. The document does not need to be complex or have elaborate policies. Failure of an employee to follow a company's code of conduct can have negative consequences. In ''Chip Skowron, Morgan Stanley v. Skowron'', 989 F. Supp. 2d 356 (S.D.N.Y. 2013), applying New York's faithless servant doctrine, the court held that a hedge fund's employee engaging in insider trading in violation of his company's code of conduct, which also required him to report his misconduct, must repay his employ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cambridge, Massachusetts
Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. It is a suburb in the Greater Boston metropolitan area, located directly across the Charles River from Boston. The city's population as of the 2020 United States census, 2020 U.S. census was 118,403, making it the most populous city in the county, the List of municipalities in Massachusetts, fourth-largest in Massachusetts behind Boston, Worcester, Massachusetts, Worcester, and Springfield, Massachusetts, Springfield, and List of cities in New England by population, ninth-most populous in New England. The city was named in honor of the University of Cambridge in Cambridge, England, which was an important center of the Puritans, Puritan theology that was embraced by the town's founders. Harvard University, an Ivy League university founded in Cambridge in 1636, is the oldest institution of higher learning in the United States. The Massachusetts Institute of Technology (MIT), Lesley University, and Hult Inte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer
Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible Signs and symptoms of cancer, signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in defecation, bowel movements. While these symptoms may indicate cancer, they can also have other causes. List of cancer types, Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor Diet (nutrition), diet, sedentary lifestyle, lack of physical activity or Alcohol abuse, excessive alcohol consumption. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. infectious causes of cancer, Infection with specific viruses, bacteria and parasites is an environmental factor cau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Billion-Dollar Molecule
''The Billion-Dollar Molecule'' is a book by journalist Barry Werth about the founding and early research efforts of the American biotechnology company Vertex Pharmaceuticals, which was founded in 1989 by Joshua Boger and was among the first biotechnology companies to adopt an explicit strategy of rational drug design as opposed to techniques based on combinatorial chemistry Combinatorial chemistry comprises chemical synthesis, chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound library, compound libraries can b .... This book is notable as an inside look at a biotechnology company, and the stresses and marketing pressures on funding research into drug design. This book is a mixture of finance and technology. In February, 2014, Barry Werth published a follow-on book, ''The Antidote'', that looks at Vertex 20 years later after his original effort. References Busin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barry Werth
Barry Werth is an American author and journalist. His work has appeared in ''The New York Times'', ''The New Yorker'', '' GQ'', the '' Smithsonian'', and the ''MIT Technology Review''. He has also served as an instructor in journalism at Smith College, Mount Holyoke College, and Boston University. Werth received a Stonewall Book Award in 2002 for ''The Scarlet Professor'', his biography of Newton Arvin, a literary critic who was publicly forced into retirement in 1960 during an anti-pornography drive by the US Post Office. The book was later adapted into the documentary film ''The Great Pink Scare'', and as a 2017 opera by Eric Sawyer and Harley Erdman based on Werth's book. His book ''Damages'' is commonly used as a case study for teaching medical malpractice in law schools. Bibliography * '' The Billion-Dollar Molecule: One Company's Quest for the Perfect Drug'' (1995) * ''Damages: One Family's Legal Struggles in the World of Medicine'' (1998) * ''The Scarlet Professor: Newton ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Boston Globe
''The Boston Globe,'' also known locally as ''the Globe'', is an American daily newspaper founded and based in Boston, Massachusetts. The newspaper has won a total of 27 Pulitzer Prizes. ''The Boston Globe'' is the oldest and largest daily newspaper in Boston and tenth-largest newspaper by print circulation in the nation as of 2023. Founded in 1872, the paper was mainly controlled by Irish Catholic interests before being sold to Charles H. Taylor and his family. After being privately held until 1973, it was sold to ''The New York Times'' in 1993 for $1.1billion, making it one of the most expensive print purchases in United States history. The newspaper was purchased in 2013 by Boston Red Sox and Liverpool F.C. owner John W. Henry for $70million from The New York Times Company, having lost over 90% of its value in 20 years. The chief print rival of ''The Boston Globe'' is the '' Boston Herald'', whose circulation is smaller and is shrinking faster. The newspaper is "one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
