Veronica Galvan
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Veronica Galvan
Veronica Galvan is a professor and the Donald W. Reynolds Endowed Chair of Aging Research in the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center. Since December 2022, she has served as director of the Oklahoma Nathan Shock Center on Aging. She also serves as co-director of the Center for Geroscience and Healthy Brain Aging at the University of Oklahoma Health Sciences Center. Galvan attended the Center for Advanced Studies in Exact Sciences University, Buenos Aires, Argentina, and received her Master's degree in 1994. She then moved to the University of Chicago where she received her Ph.D. in Virology in 1999 under the mentorship of Dr. Bernard Roizman. She then moved to the Buck Institute for Research on Aging where she completed postdoctoral research in Neuroscience under the mentorship of Dr. Dale Bredesen. She joined the faculty of the University of Texas Health Science Center San Antonio in 1999 as an assistant professor, ...
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University Of Oklahoma Health Sciences Center
The University of Oklahoma Health Sciences Center in Oklahoma City, Oklahoma, United States, is the health sciences branch of the University of Oklahoma. It serves as the primary place of training for many of Oklahoma's health professions. It is one of only four health centers in the United States with seven professional colleges. The nineteen buildings that make up the OUHSC campus occupies a fifteen block area in Oklahoma City near the Oklahoma State Capitol. Surrounding these buildings are an additional twenty health-related buildings some of which are owned by the University of Oklahoma. The Health Sciences Center is the core of a wider complex known as the Oklahoma Health Center. The major clinical facilities on campus are part of OU Medicine and include the OU Medical Center hospital complex, The Children's Hospital, OU Physicians and OU Children's Physicians clinics, Harold Hamm Diabetes Center and the Peggy and Charles Stephenson Oklahoma Cancer Center. Also part of the m ...
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University Of Chicago
The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chicago, South Side, near the shore of Lake Michigan about from Chicago Loop, the Loop. The university is composed of an College of the University of Chicago, undergraduate college and four graduate divisions: Biological Science, Arts & Humanities, Physical Science, and Social Science, which include various organized departments and institutes. In addition, the university operates eight professional schools in the fields of University of Chicago Booth School of Business, business, Crown Family School of Social Work, Policy, and Practice, social work, University of Chicago Divinity School, divinity, Graham School of Continuing Liberal and Professional Studies, continuing studies, Harris School of Public Policy, public policy, University of Chi ...
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Bernard Roizman
Bernard Roizman (born April 17, 1929) is an American scientist born in Romania. He is the Joseph Regenstein Distinguished Service Professor of Virology in the Departments of Microbiology and Molecular Genetics and Cell Biology at the University of Chicago. Early life and education Roizman was born in Chișinău, Kingdom of Romania in 1929. As he later recalled, his early life was "shaped by World War II" and the hardships his family endured as war refugees after being displaced in 1941 by the German invasion of the Soviet Union. The family eventually made their way to the United States in 1948, where they settled in Philadelphia. Roizman received a scholarship to attend a Pennsylvanian college and enrolled at Temple University, from which he received his bachelor's and master's degrees. He subsequently attended the Johns Hopkins School of Public Health, where he received his Sc.D. in 1956. Academic career and research Roizman joined the faculty at Johns Hopkins after graduation, ...
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Buck Institute For Research On Aging
The Buck Institute for Research on Aging is an independent biomedical research institute that researches aging and age-related disease. The mission of the Buck Institute is to extend the healthy years of life. The Buck Institute is one of nine centers for aging research of the Glenn Foundation for Medical Research. The institute, a nonprofit organization located in Novato, California, began its research program in 1999, making it the world's first institute founded primarily to study intervention into the aging process. It is named for Marin County philanthropists Leonard and Beryl Hamilton Buck, whose estate funded the endowment that helped establish the institute, and the Buck Trust currently contributes approximately $6 million annually to support the institute's work. The campus of the Buck Institute was designed by architect I. M. Pei. In May 2007, the institute established a cooperative agreement with the University of California's Davis and Merced campuses to coordinate ste ...
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University Of Texas Health Science Center, San Antonio
The University of Texas System (UT System) is a public university system in the U.S. state of Texas. It includes nine universities and five independent health institutions. The UT System is headquartered in Downtown Austin. It is the largest university system in Texas with 250,000+ enrolled students, 21,000+ employed faculty, 83,000+ health care professionals, researchers and support staff. The UT System's $47.5 billion endowment (as of the 2024 fiscal year) is the largest of any public university system in the United States. Component institutions Academic institutions The University of Texas System includes nine universities, each of which confers its own degrees. File:Sfastatue.jpg, Stephen F. Austin File:University of Texas at Arlington March 2021 099 (Greene Research Quad and Engineering Research Building).jpg, UT Arlington File:UT tower lit entirely in orange.jpg, UT Austin File:UT Dallas Student Service Building.JPG, UT Dallas File:Building on the campus of the ...
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American Aging Association
The American Aging Association is a non-profit, tax-exempt biogerontology organization of scientists and laypeople dedicated to biomedical aging studies and geroscience, with the goal of slowing the aging process to extend the healthy human lifespan while preserving and restoring functions typically lost to age-related degeneration. The abbreviation AGE is intended to be representative of the organization, even though it is not an acronym (avoids possible confusion with the American Automobile Association, AAA). History and organization AGE was founded in 1970 by Denham Harman, MD, PhD, who is often known as the "father" of the " free-radical theory of aging". Harman's goal was to form a lay-scientific organization patterned after the American Heart Association to promote biomedical aging research. Harman served as the first president of AGE, and was executive director of AGE for 20 years (1973 to 1993). AGE has received research grants from the National Institutes of Hea ...
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GeroScience
''GeroScience'' (formerly ''Age''; ''Journal of the American Aging Association'') is a scientific journal focused on the biology of aging and on mechanistic studies using clinically relevant models of aging and chronic age-related diseases. The journal also publishes articles on health-related aspects of human aging, including biomarkers of aging, multisystem physiology of aging and pathophysiology of age-related diseases. Topics ''GeroScience'' covers topics like chronic low-grade inflammation, cellular senescence, macromolecular damage, oxidative-nitrative stress, maladaptation to cellular and molecular stresses, impaired stem cell function and regeneration, alterations in proteostasis, epigenetic dysregulation, impaired mitochondrial function and cellular metabolism; strategies to improve cardiovascular, neurocognitive, and musculoskeletal health-span; studies using a variety of experimental approaches, including in vivo studies and investigations using isolated tissue prep ...
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Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to twelve years. The causes of Alzheimer's disease remain poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. Other risk factors include a history of head injury, clinical depression, and high blood pressure. The progression of the di ...
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Tauopathies
Tauopathies are a class of neurodegenerative diseases characterized by the aggregation of abnormal tau protein. Hyperphosphorylation of tau proteins causes them to dissociate from microtubules and form insoluble aggregates called neurofibrillary tangles. Various neuropathologic phenotypes have been described based on the anatomical regions and cell types involved as well as the unique tau isoforms making up these deposits. The designation 'primary tauopathy' is assigned to disorders where the predominant feature is the deposition of tau protein. Alternatively, diseases exhibiting tau pathologies attributed to different and varied underlying causes are termed 'secondary tauopathies'. Some neuropathologic phenotypes involving tau protein are Alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration. Tau protein Tau protein, also called tubulin associated unit or microtubule-associated protein tau (MAPT), is a microtubule-associated pr ...
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MTOR
The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the ''MTOR'' gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenanc ...
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Sirolimus
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to interleukin-2 (IL-2), inhibiting their activity. This compound also has a use in cardiovascular drug-eluting stent technologies to inhibit restenosis. It is produced by the bacterium '' Streptomyces hygroscopicus'' and was isolated for the first time in 1972, from samples of ''Streptomyces hygroscopicus'' found on Easter Island. The compound was originally named rapamycin after the native name of the island, Rapa Nui. Sirolimus was initially deve ...
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University Of Oklahoma Faculty
A university () is an institution of tertiary education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase , which roughly means "community of teachers and scholars". Universities typically offer both undergraduate and postgraduate programs. The first universities in Europe were established by Catholic monks. The University of Bologna (), Italy, which was founded in 1088, is the first university in the sense of: *being a high degree-awarding institute. *using the word (which was coined at its foundation). *having independence from the ecclesiastic schools and issuing secular as well as non-secular degrees (with teaching conducted by both clergy and non-clergy): grammar, rhetoric, logic, theology, canon law and notarial law.Hunt Janin: "The university in medieval life, 1179–1499", McFarland, 2008, , p. 55f.de Ridder-Symoens, Hilde''A History of the University in Europe: Volume 1, Universities in the M ...
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