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Tx2-6
Tx2-6 is a toxin found in the venom of the Brazilian wandering spider, '' Phoneutria nigriventer'' (Keyserling). It is a peptide of 48 residues, molecular weight 5291.3. This peptide is cleaved from a longer precursor with a signal peptide and a glutamine-rich propeptide. It can cause priapism. Tests on rats indicate that the toxin causes nitric oxide release, and its effect on erection is blocked by the nitric oxide synthase inhibitor L-NAME. However, it fully restored erectile function in rats developing hypertension due to injection of deoxycorticosterone acetate. A study is underway at the Medical College of Georgia looking at possible uses for the chemical in erectile dysfunction medication. Scientists and Gregory Ochs (Dobbs 2) are collaborating on this study. See also *Pharmacology *Spiders Spiders ( order Araneae) are air-breathing arthropods that have eight legs, chelicerae with fangs generally able to inject venom, and spinnerets that extrude silk. They ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phoneutria Nigriventer
''Phoneutria nigriventer'' is a species of medically significant spider in the family Ctenidae, found in the Southern Cone of South America (Brazil, Uruguay, Paraguay, and Argentina). Along with other members of the genus, they are often referred to as Brazilian wandering spiders. Its bite can cause severe symptoms, including extraordinary pain, increased pulse, blood pressure, and respiratory rate, penile erection (priapism) that lasts for several hours, and in several documented cases, death.Natural Viagra: Spider bite causes prolonged erection ''Live Science'', April 30, 2007. Accessed July 9, 2019. Description and behavior ''Phoneutria nigriventer'' is a large spider. Its maximum body length is around 5 cm and its legs can span 15 ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brazilian Wandering Spider
''Phoneutria'' is a genus of spiders in the family Ctenidae. Phoneutria venom is potentially medically significant to humans. They are mainly found in northern South America, with one species in Central America. Members of the genus are commonly referred to as Brazilian wandering spiders. Other English names include armed spiders (''armadeiras'' in Brazilian Portuguese) and banana spiders (a name shared with several others). Description The spiders in the genus can grow to have a leg span of . Their body length ranges from . While some other araneomorph spiders have a longer leg span, the largest ''Phoneutria'' species have the longest body and the greatest body weight in this group. The genus is distinguished from other related genera such as '' Ctenus'' by the presence of dense prolateral scopulae (a dense brush of fine hairs) on the pedipalp tibiae and tarsi in both sexes. ''Phoneutria'' are easily confused with several other non-medically significant ctenids, especially ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabili ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erectile Dysfunction
Erectile dysfunction (ED), also called impotence, is the type of sexual dysfunction in which the penis fails to become or stay erect during sexual activity. It is the most common sexual problem in men.Cunningham GR, Rosen RC. Overview of male sexual dysfunction. In: UpToDate, Martin KA (Ed), UpToDate, Waltham, MA, 2018. Through its connection to self-image and to problems in sexual relationships, erectile dysfunction can cause psychological harm. In about 80% of cases, physical causes can be identified. These include cardiovascular disease; diabetes mellitus; neurological problems, such as those following prostatectomy; hypogonadism; and drug side effects. About 10% of cases are psychological impotence, caused by thoughts or feelings; here, there is a strong response to placebo treatment. The term ''erectile dysfunction'' is not used for other disorders of erection, such as priapism. Treatment involves addressing the underlying causes, lifestyle modifications, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical College Of Georgia
The Medical College of Georgia (often referred to as MCG) is the flagship medical school of the University System of Georgia, the state's only public medical school, and one of the top 10 largest medical schools in the United States. Established in 1828 as the Medical Academy of Georgia, MCG is the oldest and founding school of Augusta University and played a role in the establishment of the American Medical Association and the standardization of medical practices. It is the third-oldest medical school in the Southeast and the 13th oldest in the nation. With 22 departments, it offers both a Doctor of Medicine (MD) as well as MD-PhD, MD-MPH, and MD-MBA degrees. Its national ranking in research is 75, and its ranking in primary care is 91, both out of 191 ranked medical schools. In response to the shortage of physicians, the school has undergone tremendous growth in recent years without lowering admissions requirements. Beginning in 2010, MCG expanded to include multiple regional ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxicon
''Toxicon'' is a peer-reviewed scientific journal of toxinology and the official journal of the International Society on Toxinology and the North American Society of Toxinology. It is published by Elsevier and the editor-in-chief is Ray Norton. It aims to publish original research, novel findings, and review papers on toxins and their chemical, toxicological, pharmacological, and immunological properties. The journal was established in 1962. According to the ''Journal Citation Reports'', ''Toxicon'' has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 3.033. References External links * {{Official, http://www.elsevier.com/wps/find/journaldescription.cws_home/259/description Publications established in 1962 Elsevier academic journals English-lan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
11-Deoxycorticosterone
11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone ( INN), deoxycortone, and cortexone, is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. It is an active (Na+-retaining) mineralocorticoid. As its names indicate, can be understood as the 21- hydroxy-variant of progesterone or as the 11- deoxy-variant of corticosterone. ''DOCA'' is the abbreviation for the ester 11-deoxycorticosterone acetate. Biological activity DOC is a potent mineralocorticoid but is virtually devoid of glucocorticoid activity. However, 11β-hydroxylation of DOC produces corticosterone and confers glucocorticoid activity, along with 10-fold reduced mineralocorticoid activity. In addition to its mineralocorticoid activity, DOC has been found to possess one-third to one-tenth the potency of progesterone as a progestogen when administered systematicall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high blood pressure, however, is a major risk factor for stroke, coronary artery disease, heart failure, atrial fibrillation, peripheral arterial disease, vision loss, chronic kidney disease, and dementia. Hypertension is a major cause of premature death worldwide. High blood pressure is classified as primary (essential) hypertension or secondary hypertension. About 90–95% of cases are primary, defined as high blood pressure due to nonspecific lifestyle and genetic factors. Lifestyle factors that increase the risk include excess salt in the diet, excess body weight, smoking, and alcohol use. The remaining 5–10% of cases are categorized as secondary high blood pressure, defined as high blood pressure due to an identifiable cause ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitric Oxide Synthase
Nitric oxide synthases () (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS ( endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease. NOS catalyzes the reaction: * 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 \rightleftharpoons 2 citrulline +2 nitric oxide + 4 H2O + 3 NADP+ NOS isoforms catalyze other leak and side reactions, such as s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitric Oxide
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its chemical formula (•N=O or •NO). Nitric oxide is also a heteronuclear diatomic molecule, a class of molecules whose study spawned early modern theories of chemical bonding. An important intermediate in industrial chemistry, nitric oxide forms in combustion systems and can be generated by lightning in thunderstorms. In mammals, including humans, nitric oxide is a signaling molecule in many physiological and pathological processes. It was proclaimed the "Molecule of the Year" in 1992. The 1998 Nobel Prize in Physiology or Medicine was awarded for discovering nitric oxide's role as a cardiovascular signalling molecule. Nitric oxide should not be confused with nitrogen dioxide (NO2), a brown gas and major air pollutant, or with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Priapism
Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after stimulation has ended. There are three types: ischemic (low-flow), nonischemic (high-flow), and recurrent ischemic (intermittent). Most cases are ischemic. Ischemic priapism is generally painful while nonischemic priapism is not. In ischemic priapism, most of the penis is hard; however, the glans penis is not. In nonischemic priapism, the entire penis is only somewhat hard. Very rarely, clitoral priapism occurs in women. Sickle cell disease is the most common cause of ischemic priapism. Other causes include medications such as antipsychotics, SSRIs, blood thinners and prostaglandin E1, as well as drugs such as cocaine. Ischemic priapism occurs when blood does not adequately drain from the penis. Nonischemic priapism is typically due to a connection forming between an artery and the corpus cavernosum or disruption of the parasympathetic nervous system resulting in increased ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
